Tyrosine-protein kinase Yes

YES1
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 2HDA
Identifiers
Aliases	YES1,HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDs	OMIM:164880;MGI:99147;HomoloGene:55900;GeneCards:YES1;OMA:YES1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.32 Start 721,588bp End 812,546bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 B1|5 17.33 cM Start 32,768,515bp End 32,844,401bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in secondary oocyte jejunal mucosa parotid gland buccal mucosa cell visceral pleura gingival epithelium parietal pleura endothelial cell corpus epididymis lactiferous duct Top expressed in lumbar spinal ganglion cumulus cell left lung lobe tail of embryo migratory enteric neural crest cell seminal vesicula Rostral migratory stream genital tubercle Gonadal ridge zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity transmembrane transporter binding epidermal growth factor receptor binding non-membrane spanning protein tyrosine kinase activity kinase activity protein binding enzyme binding protein tyrosine kinase activity signaling receptor binding ATP binding phosphotyrosine residue binding Cellular component Golgi apparatus membrane focal adhesion extrinsic component of cytoplasmic side of plasma membrane plasma membrane microtubule organizing center actin filament extracellular exosome cytoskeleton cytoplasm cytosol glutamatergic synapse postsynaptic specialization, intracellular component Biological process cellular response to transforming growth factor beta stimulus cellular response to retinoic acid cell differentiation Fc-gamma receptor signaling pathway involved in phagocytosis phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway ephrin receptor signaling pathway T cell costimulation cellular response to platelet-derived growth factor stimulus protein phosphorylation regulation of vascular permeability regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine autophosphorylation protein autophosphorylation leukocyte migration positive regulation of transcription by RNA polymerase II innate immune response cell migration regulation of glucose transmembrane transport Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 7525 22612 Ensembl ENSG00000176105 ENSMUSG00000014932 UniProt P07947 Q04736 RefSeq (mRNA) NM_005433 NM_001205132 NM_001205133 NM_009535 RefSeq (protein) NP_005424 NP_001192061 NP_001192062 NP_033561 Location (UCSC) Chr 18: 0.72 – 0.81 Mb Chr 5: 32.77 – 32.84 Mb PubMedsearch
Wikidata
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Tyrosine-protein kinase Yesis anon-receptor tyrosine kinasethat in humans is encoded by theYES1gene.

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to thesrc family.This gene lies in close proximity tothymidylate synthasegene onchromosome 18,and a correspondingpseudogenehas been found on chromosome 22.

Interactions

YES1 has been shown tointeractwithJanus kinase 2,CTNND1,RPL10andOccludin.

Further reading

• Brickell PM (1992). "The p60c-src family of protein-tyrosine kinases: structure, regulation, and function".Critical Reviews in Oncogenesis.3(4): 401–46.PMID1384720.
• Toyoshima K, Semba K, Nishizawa M, et al. (1988). "Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family".Int. Symp. Princess Takamatsu Cancer Res. Fund.17:11–20.PMID3332005.
• Sudol M, Chen HI, Bougeret C, et al. (1995)."Characterization of a novel protein-binding module--the WW domain".FEBS Lett.369(1): 67–71.doi:10.1016/0014-5793(95)00550-S.PMID7641887.S2CID20664267.
• Summy JM, Sudol M, Eck MJ, et al. (2004)."Specificity in signaling by c-Yes".Front. Biosci.8(6): s185–205.doi:10.2741/1011.PMID12456296.
• Cichowski K, McCormick F, Brugge JS (1992)."p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets".J. Biol. Chem.267(8): 5025–8.doi:10.1016/S0021-9258(18)42721-4.PMID1544885.
• Huang MM, Bolen JB, Barnwell JW, et al. (1991)."Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets".Proc. Natl. Acad. Sci. U.S.A.88(17): 7844–8.Bibcode:1991PNAS...88.7844H.doi:10.1073/pnas.88.17.7844.PMC52400.PMID1715582.
• Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H (1992)."Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase".Proc. Natl. Acad. Sci. U.S.A.88(23): 10411–5.Bibcode:1991PNAS...8810411H.doi:10.1073/pnas.88.23.10411.PMC52938.PMID1720539.
• Krueger J, Zhao YH, Murphy D, Sudol M (1991). "Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis".Oncogene.6(6): 933–40.PMID2067846.
• Zhao YH, Krueger JG, Sudol M (1991). "Expression of cellular-yes protein in mammalian tissues".Oncogene.5(11): 1629–35.PMID2267131.
• Sukegawa J, Semba K, Yamanashi Y, et al. (1987)."Characterization of cDNA clones for the human c-yes gene".Mol. Cell. Biol.7(1): 41–7.doi:10.1128/MCB.7.1.41.PMC365039.PMID2436037.
• Bull HA, Brickell PM, Dowd PM (1994)."Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells".FEBS Lett.351(1): 41–4.doi:10.1016/0014-5793(94)00814-0.PMID7521304.S2CID45071719.
• Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase".Biochem. Biophys. Res. Commun.209(2): 656–63.doi:10.1006/bbrc.1995.1549.PMID7537495.
• Courtneidge SA, Dhand R, Pilat D, et al. (1993)."Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor".EMBO J.12(3): 943–50.doi:10.1002/j.1460-2075.1993.tb05735.x.PMC413295.PMID7681396.
• Mori S, Rönnstrand L, Yokote K, et al. (1993)."Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases".EMBO J.12(6): 2257–64.doi:10.1002/j.1460-2075.1993.tb05879.x.PMC413454.PMID7685273.
• Waltenberger J, Claesson-Welsh L, Siegbahn A, et al. (1994)."Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor".J. Biol. Chem.269(43): 26988–95.doi:10.1016/S0021-9258(18)47116-5.PMID7929439.
• Silverman GA, Kuo WL, Taillon-Miller P, Gray JW (1993). "Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18".Genomics.15(2): 442–5.doi:10.1006/geno.1993.1086.PMID8449516.

External links

• Overview of all the structural information available in thePDBforUniProt:P07947(Tyrosine-protein kinase Yes) at thePDBe-KB.