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Tisopurine

From Wikipedia, the free encyclopedia
Tisopurine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 1,2-Dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-thione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.023.865 Edit this at Wikidata
Chemical and physical data
FormulaC5H4N4S
Molar mass152.18 g·mol−1
3D model (JSmol)
  • c1c2c([nH]n1)ncnc2S
  • InChI=1S/C5H4N4S/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
  • Key:PYAOPMWCFSVFOT-UHFFFAOYSA-N
  (verify)

Tisopurine (or thiopurinol) is a drug used in the treatment of gout in some countries.[1] It reduces uric acid production through inhibiting an early stage in its production.[2]

References

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  1. ^ Dean BM, Perrett D, Simmonds HA, Grahame R (April 1974). "Thiopurinol: comparative enzyme inhibition and protein binding studies with allopurinol, oxipurinol and 6-mercaptopurine". British Journal of Clinical Pharmacology. 1 (2): 119–27. doi:10.1111/j.1365-2125.1974.tb00220.x. PMC 1402452. PMID 22454898.
  2. ^ Jawad AS (June 1987). "Alternatives to allopurinol". Annals of the Rheumatic Diseases. 46 (6): 493. doi:10.1136/ard.46.6.493-a. PMC 1002174. PMID 3632073.