Jump to content

CDCP1

From Wikipedia, the free encyclopedia

CDCP1
Identifiers
AliasesCDCP1, CD318, SIMA135, TRASK, CUB domain containing protein 1
External IDsOMIM: 611735; MGI: 2442010; HomoloGene: 11276; GeneCards: CDCP1; OMA:CDCP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022842
NM_178181

NM_133974

RefSeq (protein)

NP_073753
NP_835488

NP_598735

Location (UCSC)Chr 3: 45.08 – 45.15 MbChr 9: 123 – 123.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene.[5][6] CDCP1 has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[6]

Function

[edit]

CDCP1 is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD). CDCP1 is cleaved by serine proteases at the extracellular domain next to Arg368 to generate a truncated molecule of 80 kDa size.[7] Different cell lines express different amounts of p140 and p80, depending on the activity of endogenous serine proteases.

The intracellular domain of CDCP1 contains five tyrosine residues - Y707, Y734, Y743, Y762 and Y806. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment.

Clinical significance

[edit]

The phosphorylation of CDCP1 is seen in many cancers, including some pre-invasive cancers as well as in invasive tumors and in tumor metastases.[8]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163814Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035498Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N (July 2001). "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer". Oncogene. 20 (32): 4402–8. doi:10.1038/sj.onc.1204566. PMID 11466621. S2CID 19987585.
  6. ^ a b "Entrez Gene: CDCP1 CUB domain containing protein 1".
  7. ^ Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM (2005). "Adhesion signaling by a novel mitotic substrate of src kinases". Oncogene. 24 (34): 5333–43. doi:10.1038/sj.onc.1208582. PMC 3023961. PMID 16007225.
  8. ^ Wortmann A, He Y, Deryugina EI, Quigley JP, Hooper JD (July 2009). "The cell surface glycoprotein CDCP1 in cancer--insights, opportunities, and challenges". IUBMB Life. 61 (7): 723–30. doi:10.1002/iub.198. PMID 19514048. S2CID 9630579.

Further reading

[edit]
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.