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CLEC4A

From Wikipedia, the free encyclopedia

CLEC4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLEC4A, CLECSF6, DCIR, DDB27, LLIR, CD367, HDCGC13P, C-type lectin domain family 4 member A, hDCIR
External IDsOMIM: 605306; MGI: 1349412; HomoloGene: 49291; GeneCards: CLEC4A; OMA:CLEC4A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016184
NM_194447
NM_194448
NM_194450

NM_001170332
NM_001170333
NM_011999

RefSeq (protein)

NP_057268
NP_919429
NP_919430
NP_919432

NP_001163803
NP_001163804
NP_036129

Location (UCSC)Chr 12: 8.12 – 8.14 MbChr 6: 123.08 – 123.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.[5][6]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response.

Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111729Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030148Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol. 163 (4): 1973–83. doi:10.4049/jimmunol.163.4.1973. PMID 10438934.
  6. ^ a b "Entrez Gene: CLEC4A C-type lectin domain family 4, member A".

Further reading

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