Fontolizumab
Tools
Actions
General
Print/export
In other projects
Appearance
From Wikipedia, the free encyclopedia
Monoclonal antibody
Monoclonal antibody | |
---|---|
Type | Whole antibody |
Source | Humanized (from mouse) |
Target | interferon gamma |
Clinical data | |
ATC code |
|
Identifiers | |
CAS Number | |
ChemSpider |
|
UNII | |
KEGG |
|
Chemical and physical data | |
Molar mass | ca. 150 kg/mol |
NY (what is this?) (verify) |
Fontolizumab (planned trade name HuZAF) is a humanized monoclonal antibody[1] and an immunosuppressive drug for the treatment of auto-immune diseases like Crohn's disease.[2] A phase II clinical trial investigating the use for rheumatoid arthritis was terminated because the first phase did not meet the endpoint.[3]
References
[edit]- ^ Statement On A Nonproprietary Name Adopted By The Usan Council - Fontolizumab, American Medical Association.
- ^ Reinisch W, de Villiers W, Bene L, Simon L, Rácz I, Katz S, et al. (February 2010). "Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study". Inflammatory Bowel Diseases. 16 (2): 233–42. doi:10.1002/ibd.21038. PMID 19637334. S2CID 25337474.
- ^ Clinical trial number NCT00281294 for "A Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid Arthritis" at ClinicalTrials.gov
Intracellular (initiation) |
| ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Intracellular (reception) |
| ||||||||||||||
Extracellular |
| ||||||||||||||
Unsorted |
|
Chemokine |
| ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CSF |
| ||||||||||||
Interferon |
| ||||||||||||
Interleukin |
| ||||||||||||
TGFβ |
| ||||||||||||
TNF |
| ||||||||||||
Others |
|
This monoclonal antibody–related article is a stub. You can help Wikipedia by expanding it. |
This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it. |
Hidden categories:
- Articles with short description
- Short description is different from Wikidata
- Articles with changed CASNo identifier
- Chemicals that do not have a ChemSpider ID assigned
- Infobox-drug molecular-weight unexpected-character
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without InChI source
- Drugs with no legal status
- Drugboxes which contain changes to verified fields
- Drugboxes which contain changes to watched fields
- Drugs that are a monoclonal antibody
- All stub articles