From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene .[ 5] [ 6] [ 7]
Activation of MRGPRX2 on mast cells leads to IgE-independent type 1 hypersensitivity -like symptoms, also known as pseudoallergic reactions , although more rapid and brief. Medications identified to cause MRGPRX2 activation including neuromuscular blocking agents (NMBA) (except for succinylcholine ), antibiotics like DNA gyrase inhibitor fluoroquinolones or cell wall synthesis inhibitor vancomycin (which caused Red Man syndrome ), icatibant , leuprolide , and morphine .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000183695 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074109 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (September 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons" . Cell . 106 (5): 619–632. doi :10.1016/S0092-8674(01)00483-4 PMID 11551509 . ^ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2" .^ a b Akin C, Elhosni M, Khokar DS (2023). "Mast Cells and Mast Cell disorders". In Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck J (eds.). Clinical immunology: principles and practice ISBN 978-0-7020-8165-1
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters . 520 (1–3): 97–101. Bibcode :2002FEBSL.520...97T . doi :10.1016/S0014-5793(02)02775-8 . PMID 12044878 . S2CID 7116392 . Robas N, Mead E, Fidock M (November 2003). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion" . The Journal of Biological Chemistry . 278 (45): 44400–44404. doi :10.1074/jbc.M302456200 PMID 12915402 . Yang S, Liu Y, Lin AA, Cavalli-Sforza LL, Zhao Z, Su B (June 2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene . 352 : 30–35. doi :10.1016/j.gene.2005.03.001 . PMID 15862286 .
