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CDH12

From Wikipedia, the free encyclopedia
CDH12
Identifiers
AliasesCDH12,CDHB, cadherin 12
External IDsOMIM:600562;MGI:109503;HomoloGene:37873;GeneCards:CDH12;OMA:CDH12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004061
NM_001317227
NM_001317228

NM_001008420

RefSeq (protein)

NP_001008420

Location (UCSC)Chr 5: 21.75 – 22.85 MbChr 15: 20.45 – 21.59 Mb
PubMedsearch[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-12is aproteinthat in humans is encoded by theCDH12gene.[5][6]

This gene encodes a type II classicalcadherinfrom the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and itstemporal patternof expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.[6]

References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000154162Ensembl,May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000040452Ensembl,May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (Jun 1995)."Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene".Proc Natl Acad Sci U S A.92(9): 3702–6.Bibcode:1995PNAS...92.3702S.doi:10.1073/pnas.92.9.3702.PMC42029.PMID7731968.
  6. ^ab"Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)".

Further reading

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