Dipeptidase 3

DPEP3
Identifiers
Aliases	DPEP3,MBD3, dipeptidase 3
External IDs	OMIM:609926;MGI:1919104;HomoloGene:23357;GeneCards:DPEP3;OMA:DPEP3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 67,975,663bp End 67,980,549bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 106,700,145bp End 106,706,061bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in right testis left testis gonad testicle sperm blood granulocyte spleen bone marrow muscle of thigh Top expressed in spermatocyte spermatid seminiferous tubule primary oocyte morula morula secondary oocyte blastocyst Gonadal ridge zygote More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloexopeptidase activity dipeptidyl-peptidase activity metallopeptidase activity hydrolase activity metal ion binding dipeptidase activity Cellular component anchored component of membrane membrane acrosomal vesicle plasma membrane Biological process male meiotic nuclear division meiosis proteolysis Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 64180 71854 Ensembl ENSG00000141096 ENSMUSG00000031898 UniProt Q9H4B8 Q9DA79 RefSeq (mRNA) NM_022357 NM_001129758 NM_001370198 NM_027960 RefSeq (protein) NP_001123230 NP_001357127 NP_082236 Location (UCSC) Chr 16: 67.98 – 67.98 Mb Chr 8: 106.7 – 106.71 Mb PubMedsearch
Wikidata
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Dipeptidase 3(DPEP3) is aproteinthat in humans is encoded by theDPEP3gene.

This gene encodes a membrane-bound glycoprotein from the family ofdipeptidases(EC 3.4.13.19) involved in hydrolytic metabolism of variousdipeptides,includingpenemandcarbapenembeta-lactamantibiotics. This gene is located on chromosome 16 in a cluster with another member of this family,DPEP2.Alternatively spliced transcript variants that encode different isoforms have been found for this gene.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
• Sabatti C,Service SK, Hartikainen AL, et al. (2009)."Genome-wide association analysis of metabolic traits in a birth cohort from a founder population".Nat. Genet.41(1): 35–46.doi:10.1038/ng.271.PMC2687077.PMID19060910.
• Clark HF, Gurney AL, Abaya E, et al. (2003)."The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment".Genome Res.13(10): 2265–70.doi:10.1101/gr.1293003.PMC403697.PMID12975309.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.