LPAR3
Appearance
Lysophosphatidic acid receptor 3also known asLPA3is aproteinthat in humans is encoded by theLPAR3gene.[5][6]LPA3is aG protein-coupled receptorthat binds the lipid signaling moleculelysophosphatidic acid(LPA).[7]
Function
[edit]This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) Alpha proteins.[5]
Evolution
[edit]See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000171517–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000036832–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ab"Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3".
- ^Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999)."Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid".J. Biol. Chem.274(39): 27776–85.doi:10.1074/jbc.274.39.27776.PMID10488122.
- ^Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions".Annual Review of Pharmacology and Toxicology.50(1): 157–186.doi:10.1146/annurev.pharmtox.010909.105753.PMID20055701.
- ^"GeneCards®: The Human Gene Database".
Further reading
[edit]- Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors".Mol. Pharmacol.58(6): 1188–96.doi:10.1124/mol.58.6.1188.PMID11093753.S2CID6936621.
- Im DS, Heise CE, Harding MA, et al. (2000). "Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate".Mol. Pharmacol.57(4): 753–9.doi:10.1124/mol.57.4.753.PMID10727522.
- Fitzgerald LR, Dytko GM, Sarau HM, et al. (2000). "Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid".Biochem. Biophys. Res. Commun.273(3): 805–10.doi:10.1006/bbrc.2000.2943.PMID10891327.
- Tokumura A, Sinomiya J, Kishimoto S, et al. (2002)."Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids".Biochem. J.365(Pt 3): 617–28.doi:10.1042/BJ20020348.PMC1222725.PMID11982483.
- Hama K, Bandoh K, Kakehi Y, et al. (2002)."Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors".FEBS Lett.523(1–3): 187–92.doi:10.1016/S0014-5793(02)02976-9.PMID12123830.S2CID44924895.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Cremers B, Flesch M, Kostenis E, et al. (2003). "Modulation of myocardial contractility by lysophosphatidic acid (LPA)".J. Mol. Cell. Cardiol.35(1): 71–80.doi:10.1016/S0022-2828(02)00279-1.PMID12623301.
- Fujita T, Miyamoto S, Onoyama I, et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer".Cancer Lett.192(2): 161–9.doi:10.1016/S0304-3835(02)00713-9.PMID12668280.
- Jin Y, Knudsen E, Wang L, Maghazachi AA (2003)."Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization".Eur. J. Immunol.33(8): 2083–9.doi:10.1002/eji.200323711.PMID12884281.S2CID41960806.
- Xing Y, Ganji SH, Noh JW, Kamanna VS (2005). "Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth".Am. J. Physiol. Renal Physiol.287(6): F1250–7.doi:10.1152/ajprenal.00342.2003.PMID15292052.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
External links
[edit]- "Lysophospholipid Receptors: LPA3".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2016-03-03.Retrieved2008-12-05.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.