Latrophilin 3
Latrophilin 3is aproteinthat in humans is encoded by theADGRL3gene.[5][6]
Function
[edit]This gene encodes a member of thelatrophilinsubfamily ofG protein-coupled receptors(GPCR). Latrophilins may function in bothcell adhesionandsignal transduction.In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellularN-terminalcell adhesion subunit and a subunit with substantial similarity to thesecretin/calcitonin familyof GPCRs) being non-covalently bound at the cell membrane.[6]
Clinical significance
[edit]A version of this gene has been linked toattention deficit hyperactivity disorder(ADHD).[7]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000150471–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000037605–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families".Journal of Receptor and Signal Transduction Research.20(2–3): 119–131.doi:10.3109/10799890009150640.PMID10994649.S2CID19919738.
- ^ab"LPHN3 latrophilin 3".Entrez Gene.U.S. National Library of Medicine.
- ^Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (November 2010)."A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication".Molecular Psychiatry.15(11): 1053–1066.doi:10.1038/mp.2010.6.hdl:11336/80502.PMID20157310.
Further reading
[edit]- Südhof TC (2001). "Alpha -Latrotoxin and its receptors: neurexins and CIRL/latrophilins".Annual Review of Neuroscience.24:933–962.doi:10.1146/annurev.neuro.24.1.933.PMID11520923.
- Ushkaryov YA, Volynski KE, Ashton AC (April 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies".Toxicon.43(5): 527–542.doi:10.1016/j.toxicon.2004.02.008.PMID15066411.
- Soares MB, Bonaldo MF, Jelene P, Su L, Lawton L, Efstratiadis A (September 1994)."Construction and characterization of a normalized cDNA library".Proceedings of the National Academy of Sciences of the United States of America.91(20): 9228–9232.Bibcode:1994PNAS...91.9228S.doi:10.1073/pnas.91.20.9228.PMC44785.PMID7937745.
- The Sanger Centre, The Washington University Genome Sequencing Center (November 1998)."Toward a complete human genome sequence".Genome Research.8(11): 1097–1108.doi:10.1101/gr.8.11.1097.PMID9847074.
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, et al. (October 1998)."Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Research.5(5): 277–286.doi:10.1093/dnares/5.5.277.PMID9872452.
- Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (October 2000)."The calcium-independent receptor for Alpha -latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins".The Journal of Biological Chemistry.275(42): 32387–32390.doi:10.1074/jbc.C000490200.PMID10964907.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84(1): 23–33.doi:10.1016/j.ygeno.2003.12.004.PMID15203201.
External links
[edit]- PDBe-KBprovides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3
- PDBe-KBprovides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.