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Artificial heart valve

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Artificial heart valve
Different types of artificial heart valves[1]
Specialtycardiology

Anartificial heart valveis aone-way valveimplantedinto a person'sheartto replace aheart valvethat is not functioning properly (valvular heart disease). Artificial heart valves can be separated into three broad classes: mechanical heart valves, bioprosthetic tissue valves and engineered tissue valves.

The human heart contains four valves:tricuspid valve,pulmonary valve,mitral valveandaortic valve.Their main purpose is to keep blood flowing in the proper direction through the heart, and from the heart into the major blood vessels connected to it (thepulmonary arteryand theaorta). Heart valves can malfunction for a variety of reasons, which can impede the flow of blood through the valve (stenosis) and/or let blood flow backwards through the valve (regurgitation). Both processes put strain on the heart and may lead to serious problems, includingheart failure.While some dysfunctional valves can be treated with drugs or repaired, others need to be replaced with an artificial valve.[2]

Background

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3D Medical Animation still shot of Artificial Heart Valve
3D Medical Animation still shot of Artificial Heart Valve

A heart contains four valves (tricuspid, pulmonary, mitral and aortic valves) which open and close as blood passes through the heart.[3]Blood enters the heart in the right atrium and passes through thetricuspid valveto the right ventricle. From there, blood is pumped through thepulmonary valveto enter the lungs. After being oxygenated, blood passes to the left atrium, where is it pumped through themitral valveto the left ventricle. The left ventricle pumps blood to the aorta through theaortic valve.

There are many potential causes of heart valve damage, such as birth defects, age related changes, and effects from other disorders, such as rheumatic fever and infections causingendocarditis.High blood pressureand heart failure which can enlarge the heart and arteries, and scar tissue can form after aheart attackor injury.[4]

The three main types of artificial heart valves are mechanical, biological (bioprosthetic/tissue), and tissue-engineered valves. In the US, UK and the European Union, the most common type of artificial heart valve is the bioprosthetic valve. Mechanical valves are more commonly used in Asia and Latin America.[citation needed]Companies that manufacture heart valves include Edwards Lifesciences,[5]Medtronic,[6]Abbott (St. Jude Medical),[7]CryoLife,[8]and LifeNet Health.[9]

Mechanical valves

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Mechanical valves come in three main types – caged ball, tilting-disc and bileaflet – with various modifications on these designs.[10]Caged ball valves are no longer implanted.[11]Bileaflet valves are the most common type of mechanical valve implanted in patients today.[12]

Caged ball valves

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Caged ball valve

The first artificial heart valve was the caged ball valve, a type ofball check valve,in which a ball is housed inside a cage. When the heart contracts and the blood pressure in the chamber of the heart exceeds the pressure on the outside of the chamber, the ball is pushed against the cage and allows blood to flow. When the heart finishes contracting, the pressure inside the chamber drops and the ball moves back against the base of the valve forming a seal.

In 1952,Charles A. Hufnagelimplanted caged ball heart valves into ten patients (six of whom survived the operation), marking the first success in prosthetic heart valves.[citation needed]A similar valve was invented by Miles 'Lowell' Edwards andAlbert Starrin 1960, commonly referred to as the Starr-Edwards silastic ball valve.[13]This consisted of a silicone ball enclosed in amethyl metacrylatecage welded to a ring. The Starr-Edwards valve was first implanted in a human on August 25, 1960, and was discontinued by Edwards Lifesciences in 2007.[13]

Caged ball valves are strongly associated with blood clot formation, so people who have one required a high degree ofanticoagulation,usually with a targetINRof 3.0–4.5.[14]

Tilting-disc valves

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tilting-disc valve

Introduced in 1969, the first clinically available tilting-disc valve was theBjork-Shiley valve.[15]Tilting‑disc valves, a type ofswing check valve,are made of a metal ring covered by anePTFEfabric. The metal ring holds, by means of two metal supports, a disc that opens when the heart beats to let blood flow through, then closes again to prevent blood flowing backwards. The disc is usually made of an extremely hard carbon material (pyrolytic carbon), enabling the valve to function for years without wearing out.[citation needed]

Bileaflet valves

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Bileaflet valve

Introduced in 1979, bileaflet valves are made of two semicircular leaflets that revolve around struts attached to the valve housing. With a larger opening than caged ball or tilting-disc valves, they carry a lower risk of blood clots. They are, however, vulnerable to blood backflow.[citation needed]

Advantages of mechanical valves

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The major advantage of mechanical valves over bioprosthetic valves is their greater durability.[16]Made from metal and/orpyrolytic carbon,[10]they can last 20–30 years.[16]

Disadvantages of mechanical valves

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One of the major drawbacks of mechanical heart valves is that they are associated with an increased risk ofblood clots.Clots formed by red blood cell and platelet damage can block blood vessels leading tostroke.People with mechanical valves need to take anticoagulants (blood thinners), such aswarfarin,for the rest of their life.[16]Mechanical heart valves can also causemechanical hemolytic anemia,a condition where thered blood cellsare damaged as they pass through the valve.[citation needed]Cavitation,the rapid formation of microbubbles in a fluid such as blood due to a localized drop of pressure, can lead to mechanical heart valve failure,[17]so cavitation testing is an essential part of the valve design verification process.

Many of the complications associated with mechanical heart valves can be explained throughfluid mechanics.For example, blood clot formation is a side effect of highshear stressescreated by the design of the valves. From an engineering perspective, an ideal heart valve would produce minimal pressure drops, have small regurgitation volumes, minimize turbulence, reduce prevalence of high stresses, and not create flow separations in the vicinity of the valve.[citation needed]

Implanted mechanical valves can cause foreign body rejection. The blood may coagulate and eventually result in a hemostasis. The usage of anticoagulation drugs will be interminable to prevent thrombosis.[18][non-primary source needed]

Bioprosthetic tissue valves

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Bioprosthetic valves are usually made from animal tissue (heterograft/xenograft) attached to a metal or polymer support.[11]Bovine (cow) tissue is most commonly used, but some are made from porcine (pig) tissue.[19][non-primary source needed]The tissue is treated to prevent rejection andcalcification.[citation needed]

Alternatives to animal tissue valves are sometimes used, where valves are used from human donors, as in aortichomograftsand pulmonaryautografts.An aortic homograft is an aortic valve from a human donor, retrieved either after their death or from a heart that is removed to be replaced during a heart transplant.[12]A pulmonary autograft, also known as theRoss procedure,is where the aortic valve is removed and replaced with the patient's ownpulmonary valve(the valve between the right ventricle and the pulmonary artery). A pulmonary homograft (a pulmonary valve taken from a cadaver) is then used to replace the patient's own pulmonary valve. This procedure was first performed in 1967 and is used primarily in children, as it allows the patient's own pulmonary valve (now in the aortic position) to grow with the child.[12]

Advantages of bioprosthetic heart valves

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Bioprosthetic valves are less likely than mechanical valves to cause blood clots, so do not require lifelong anticoagulation. As a result, people with bioprosthetic valves have a lower risk of bleeding than those with mechanical valves.[16]

Disadvantages of bioprosthetic heart valves

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Tissue valves are less durable than mechanical valves, typically lasting 10–20 years.[20]This means that people with bioprosthetic valves have a higher incidence of requiring another aortic valve replacement in their lifetime.[16]Bioprosthetic valves tend to deteriorate more quickly in younger patients.[21]

In recent years, scientists have developed a new tissue preservation technology, with the aim of improving the durability of bioprosthetic valves. In sheep and rabbit studies, tissue preserved using this new technology had lesscalcificationthan control tissue.[22]A valve containing this tissue is now marketed, but long-term durability data in patients are not yet available.[23][non-primary source needed]

Current bioprosthetic valves lack longevity, and will calcify over time.[24]When a valve calcifies, the valve cusps become stiff and thick and cannot close completely.[24]Moreover, bioprosthetic valves can't grow with or adapt to the patient: if a child has bioprosthetic valves they will need to get the valves replaced several times to fit their physical growth.[24]

Tissue-engineered valves

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For over 30 years researchers have been trying to grow heart valvesin vitro.[25]These tissue‑engineered valves involve seeding human cells on to a scaffold.[25]The two main types of scaffold are natural scaffolds, such as decellularized tissue, or scaffolds made from degradable polymers.[26]The scaffold acts as anextracellular matrix,guiding tissue growth into the correct 3D structure of the heart valve.[26][25]Some tissue-engineered heart valves have been tested in clinical trials,[26]but none are commercially available.

Tissue engineered heart valves can be person-specific and 3D modeled to fit an individual recipient[27]3D printing is used because of its high accuracy and precision of dealing with different biomaterials.[27]Cells that are used for tissue engineered heart valves are expected to secrete the extracellular matrix (ECM).[24]Extracellular matrix provides support to maintain the shape of the valves and determines the cell activities.[28]

Scientists can follow the structure of heart valves to produce something that looks similar to them, but since tissue engineered valves lack the natural cellular basis, they either fail to perform their functions like natural heart valves, or function when they are implanted but gradually degrade over time.[citation needed]An ideal tissue engineered heart valve would be non-thrombogenic, biocompatible, durable, resistant to calcification, grow with the surrounding heart, and exhibit a physiological hemodynamic profile.[29]To achieve these goals, the scaffold should be carefully chosen—there are three main candidates: decellularized ECM (xenografts or homografts), natural polymers, and synthetic polymers.[29]

Differences between mechanical and tissue valves

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Mechanical and tissue valves are made of different materials. Mechanical valves are generally made of titanium and carbon.[30]Tissue valves are made up of human or animal tissue. The valves composed of human tissue, known as allografts or homografts, are from donors' human hearts.[30]

Mechanical valves can be a better choice for younger people and people at risk of valve deterioration due to its durability. It is also preferable for people who are already taking blood thinners and people who would be unlikely to tolerate another valve replacement operation.[citation needed]

Tissue valves are better for older age groups as another valve replacement operation may not be needed in their lifetime. Due to the risk of forming blood clots for mechanical valves and severe bleeding as a major side effect of taking blood-thinning medications, people who have a risk of blood bleeding and are not willing to take warfarin may also consider tissue valves. Other patients who may be more suitable for tissue valves are people who have other planned surgeries and unable to take blood-thinning medications. People who plan to become pregnant may also consider tissue valves as warfarin causes risks in pregnancy.[citation needed]

Functional requirements of artificial heart valves

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An artificial heart valve should ideally function like a natural heart valve.[11]The functioning of natural heart valves is characterized by many advantages:

  • Minimalregurgitation– This means that the amount ofbloodleaking backwards through the valve as it closes is small. Some degree of valvular regurgitation is inevitable and natural, up to around 5 ml per beat.[31]However, several heart valve pathologies (e.g. rheumaticendocarditis) may lead to clinically significant valvular regurgitation. A desirable characteristic of heart valve prostheses is that regurgitation is minimal over the full range ofphysiologicalheart function.
  • Minimal transvalvular pressure gradient – Whenever afluidflows through a restriction, such as a valve, apressuregradientarises over the restriction. This pressure gradient is a result of the increased resistance to flow through the restriction. Natural heart valves have a low transvalvular pressure gradient as they present little obstruction to the flow through themselves, normally less than 16 mmHg. A desirable characteristic of heart valve prostheses is that their transvalvular pressure gradient is as small as possible.
  • Non-thrombogenic– Natural heart valves are lined with anendotheliumcomparable with the endothelium lining the heart chambers, so they are not normally thrombogenic (i.e. they don't cause blood clots). Blood clots can be hazardous because they can lodge in, and block, downstreamarteries(e.g.coronary arteries,leading to heart attack [myocardial infarction]; orcerebral arteries,leading tostroke). A desirable characteristic of artificial heart valves is that they are non- or minimally thrombogenic.
  • Self-repairing – Valve leaflets retain some capacity for repair thanks to regenerativecells(e.g.fibroblasts) in theconnective tissuefrom which the leaflets are composed. As the human heart beats approximately 3.4×109times during a typical human lifespan, this limited but nevertheless present repair capacity is critically important. No heart valve prostheses can currently self-repair, but tissue-engineered valves may eventually offer such capabilities.[26]

The performance of an artificial heart valve can be testedin vitrobefore clinical use by means of apulse duplicator.[32]

Artificial heart valve repair

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Artificial heart valves are expected to last from 10 to 30 years.[16]

The most common problems with artificial heart valves are various forms of degeneration, including gross billowing of leaflets, ischemic mitral valve pathology, and minor chordal lengthening.[24]The repairing process of the artificial heart valve regurgitation and stenosis usually requires an open-heart surgery, and a repair or partial replacement of regurgitant valves is usually preferred.[24]

Researchers are investigating catheter-based surgery that allows repair of an artificial heart valve without large incisions.[33]

Researchers are investigating Interchangeable Prosthetic Heart Valve that allows redo and fast-track repair of an artificial heart valve.[34]

Additional images

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  • 3D Rendering of Mechanical Valve
    3D Rendering of Mechanical Valve
  • 3D Rendering of Mechanical Valve (St. Francis model)
    3D Rendering of Mechanical Valve (St. Francis model)

See also

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References

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  2. ^Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, et al. (September 2017)."2017 ESC/EACTS Guidelines for the management of valvular heart disease".European Heart Journal.38(36): 2739–2791.doi:10.1093/eurheartj/ehx391.PMID28886619.
  3. ^"Heart Valve Replacement: Which Type Is Best for You?".Health Essentials from Cleveland Clinic.2018-06-14.Archivedfrom the original on 2020-09-15.Retrieved2020-08-04.
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  15. ^Sun JC, Davidson MJ, Lamy A, Eikelboom JW (August 2009). "Antithrombotic management of patients with prosthetic heart valves: current evidence and future trends".Lancet.374(9689): 565–76.doi:10.1016/S0140-6736(09)60780-7.PMID19683642.S2CID43661491.
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  20. ^Harris C, Croce B, Cao C (July 2015)."Tissue and mechanical heart valves".Annals of Cardiothoracic Surgery.4(4): 399.doi:10.3978/j.issn.2225-319X.2015.07.01.PMC4526499.PMID26309855.Archivedfrom the original on 2019-07-29.Retrieved2019-07-29.
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  22. ^Flameng W, Hermans H, Verbeken E, Meuris B (January 2015)."A randomized assessment of an advanced tissue preservation technology in the juvenile sheep model".The Journal of Thoracic and Cardiovascular Surgery.149(1): 340–5.doi:10.1016/j.jtcvs.2014.09.062.PMID25439467.
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  24. ^abcdefHasan A, Saliba J, Pezeshgi Modarres H, Bakhaty A, Nasajpour A, Mofrad MR, Sanati-Nezhad A (October 2016). "Micro and nanotechnologies in heart valve tissue engineering".Biomaterials.103:278–292.doi:10.1016/j.biomaterials.2016.07.001.PMID27414719.
  25. ^abcStassen OM, Muylaert DE, Bouten CV, Hjortnaes J (September 2017)."Current Challenges in Translating Tissue-Engineered Heart Valves".Current Treatment Options in Cardiovascular Medicine.19(9): 71.doi:10.1007/s11936-017-0566-y.PMC5545463.PMID28782083.
  26. ^abcdBlum KM, Drews JD, Breuer CK (June 2018)."Tissue-Engineered Heart Valves: A Call for Mechanistic Studies".Tissue Engineering. Part B, Reviews.24(3): 240–253.doi:10.1089/ten.teb.2017.0425.PMC5994154.PMID29327671.
  27. ^abTheus AS, Tomov ML, Cetnar A, Lima B, Nish J, McCoy K, Mahmoudi M, Serpooshan V (2019-06-01). "Biomaterial approaches for cardiovascular tissue engineering".Emergent Materials.2(2): 193–207.doi:10.1007/s42247-019-00039-3.ISSN2522-574X.S2CID201165755.
  28. ^Hay ED (2013-11-11).Cell Biology of Extracellular Matrix(Second ed.). Springer Science & Business Media.ISBN978-1-4615-3770-0.
  29. ^abNachlas AL, Li S, Davis ME (December 2017). "Developing a Clinically Relevant Tissue Engineered Heart Valve-A Review of Current Approaches".Advanced Healthcare Materials.6(24): 1700918.doi:10.1002/adhm.201700918.PMID29171921.S2CID2339263.
  30. ^abSchmidt JB, Tranquillo RT (2013).Tissue-Engineered Heart Valves.Boston, MA: Springer US. pp. 261–280.doi:10.1007/978-1-4614-6144-9_11.ISBN978-1-4614-6143-2.{{cite book}}:|work=ignored (help)
  31. ^Kasegawa H, Iwasaki K, Kusunose S, Tatusta R, Doi T, Yasuda H, Umezu M (January 2012). "Assessment of a novel stentless mitral valve using a pulsatile mitral valve simulator".The Journal of Heart Valve Disease.21(1): 71–5.PMID22474745.
  32. ^Mashari A, Knio Z, Jeganathan J, Montealegre-Gallegos M, Yeh L, Amador Y; et al. (2016)."Hemodynamic Testing of Patient-Specific Mitral Valves Using a Pulse Duplicator: A Clinical Application of Three-Dimensional Printing".Journal of Cardiothoracic and Vascular Anesthesia.30(5): 1278–85.doi:10.1053/j.jvca.2016.01.013.PMID27179613.{{cite journal}}:CS1 maint: multiple names: authors list (link)
  33. ^Bezuidenhout D, Williams DF, Zilla P (January 2015). "Polymeric heart valves for surgical implantation, catheter-based technologies and heart assist devices".Biomaterials.36:6–25.doi:10.1016/j.biomaterials.2014.09.013.PMID25443788.
  34. ^Roberto de Menezes Lyra | title = Eight Types of Interchangeable Prosthetic Heart Valve: A Mini Review. | journal =https://globaljournals.orgArchived2023-03-22 at theWayback Machine|https://globaljournals.org/GJMR_Volume22/2-Eight-Types-of-Interchangeable-Prosthetic-Heart-Valve.pdfArchived2023-03-22 at theWayback Machine

Further reading

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  • Bendet I, Morozov SM,Skumin VA[in French](June 1980). "[Psychological aspects of the rehabilitation of patients after the surgical treatment of heart defects]"Психологические аспекты реабилитации больных после хирургического лечения пороков сердца[Psychological aspects of the rehabilitation of patients after the surgical treatment of heart defects].Kardiologiia(in Russian).20(6): 45–51.PMID7392405.
  • Skumin VA[in French](September 1979). "[Nurse's role in medico-psychological rehabilitation of patients with artificial heart valves]".Meditsinskaia Sestra.38(9): 44–5.PMID259874.
  • Skumin VA[in French](1982). "[Nonpsychotic mental disorders in patients with acquired heart defects before and after surgery (review)]".Zhurnal Nevropatologii I Psikhiatrii imeni S.S. Korsakova.82(11): 130–5.PMID6758444.
  • Klepetko W, Moritz A, Mlczoch J, Schurawitzki H, Domanig E, Wolner E (January 1989)."Leaflet fracture in Edwards-Duromedics bileaflet valves".The Journal of Thoracic and Cardiovascular Surgery.97(1): 90–4.doi:10.1016/S0022-5223(19)35130-X.PMID2911200.
  • Podesser BK, Khuenl-Brady G, Eigenbauer E, Roedler S, Schmiedberger A, Wolner E, Moritz A (May 1998)."Long-term results of heart valve replacement with the Edwards Duromedics bileaflet prosthesis: a prospective ten-year clinical follow-up".The Journal of Thoracic and Cardiovascular Surgery.115(5): 1121–9.doi:10.1016/s0022-5223(98)70412-x.PMID9605082.
  • Knapp RJ, Daily JW, Hammitt FG (1970).Cavitation.New York: McGraw-Hill Int. Book Co.
  • Lim WL, Chew YT, Low HT, Foo WL (September 2003). "Cavitation phenomena in mechanical heart valves: the role of squeeze flow velocity and contact area on cavitation initiation between two impinging rods".Journal of Biomechanics.36(9): 1269–80.doi:10.1016/s0021-9290(03)00161-1.PMID12893035.
  • Bluestein D, Einav S, Hwang NH (November 1994). "A squeeze flow phenomenon at the closing of a bileaflet mechanical heart valve prosthesis".Journal of Biomechanics.27(11): 1369–78.doi:10.1016/0021-9290(94)90046-9.PMID7798287.
  • Graf T, Fischer H, Reul H, Rau G (March 1991). "Cavitation potential of mechanical heart valve prostheses".The International Journal of Artificial Organs.14(3): 169–74.doi:10.1177/039139889101400309.PMID2045192.S2CID23086590.
  • Kafes gian R, Wieting DW, Ely J, Chahine GL, Frederick GS, Watson RE (1990). "Characterization of Cavitation Potential of Pyrolitic Carbon". In Bodnar E (ed.).Surgery for Heart Valve Disease: Proceedings of the 1989 Symposium.ICR. pp. 509–16.ISBN978-1-872743-00-4.
  • Chahine GL (March 1996). "Scaling of mechanical heart valves for cavitation inception: observation and acoustic detection".The Journal of Heart Valve Disease.5(2): 207–14, discussion 214–5.PMID8665016.
  • Zapanta CM, Stinebring DR, Sneckenberger DS, Deutsch S, Geselowitz DB, Tarbell JM, et al. (1996)."In vivo observation of cavitation on prosthetic heart valves".ASAIO Journal.42(5): M550-5.doi:10.1097/00002480-199609000-00047.PMID8944940.
  • Richard G, Beavan A, Strzepa P (April 1994). "Cavitation threshold ranking and erosion characteristics of bileaflet heart valve prostheses".The Journal of Heart Valve Disease.3(Suppl 1): S94-101.PMID8061875.
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