Vedaprofen
Appearance
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Names | |
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IUPAC name
2-(4-Cyclohexyl-1-naphthyl)propanoic acid
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.068.339 |
PubChemCID
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UNII | |
CompTox Dashboard(EPA)
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Properties | |
C19H22O2 | |
Molar mass | 282.383g·mol−1 |
Pharmacology | |
QM01AE90(WHO) | |
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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Vedaprofenis anonsteroidal anti-inflammatory drug(NSAID) used inveterinary medicinefor the treatment of pain and inflammation due to musculoskeletal disorders in dogs and horses and for the treatment of pain due tohorse colic.[1]It is a member of theprofendrug class.
Synthesis
[edit]Vedaprofen can be synthesized beginning with 1-cyclohexylnaphthylene (left).[2][3]Chloromethylation followed by functional group interconversion provides the ester (center right).Alkylationwithmethyl iodidethen gives vedaprofen (right).
![](https://upload.wikimedia.org/wikipedia/commons/thumb/b/b3/Vedaprofen_synthesis.png/600px-Vedaprofen_synthesis.png)
References
[edit]- ^"Specific Nonsteroidal Anti-inflammatory Drugs".Merck Veterinary Manual.Merck Sharp & Dohme Corp.
- ^BE 870553
- ^U.S. patent 4,218,473