40S ribosomal protein S5

RPS5
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4UG0,4V6X,5A2Q,5AJ0,3J7P,4KZX,4UJE,4KZY,4D5L,4KZZ,3J7R,4UJD,4V5Z,5FLX,4D61,4UJC,%%s4KZY,3J7R,4D61,4KZX,4D5L,4V5Z,5A2Q,4V6X,4UJD,3J7P,5AJ0,4KZZ,4UG0,4UJE,4UJC,5FLX
Identifiers
Aliases	RPS5,S5, ribosomal protein S5
External IDs	OMIM:603630;MGI:1097682;HomoloGene:783;GeneCards:RPS5;OMA:RPS5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.43 Start 58,386,400bp End 58,394,806bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 12,656,217bp End 12,660,613bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in gonad vulva trabecular bone mucosa of sigmoid colon skin of arm human penis left ovary oral cavity superficial temporal artery skin of thigh Top expressed in Gonadal ridge mandibular prominence maxillary prominence efferent ductule internal carotid artery somite medial ganglionic eminence precursor cell migratory enteric neural crest cell external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding mRNA binding RNA binding rRNA binding Cellular component cytosol ribosome membrane focal adhesion small ribosomal subunit extracellular exosome extracellular matrix nucleoplasm cytosolic small ribosomal subunit ribonucleoprotein complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation regulation of translational fidelity nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis ribosomal small subunit assembly Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 6193 20103 Ensembl ENSG00000083845 ENSMUSG00000012848 UniProt P46782 P97461 RefSeq (mRNA) NM_001009 NM_009095 RefSeq (protein) NP_001000 NP_001000.2 NP_033121 Location (UCSC) Chr 19: 58.39 – 58.39 Mb Chr 7: 12.66 – 12.66 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S5is aribosomalsubunit of theEukaryotic ribosome (80S)complex. In humans it is encoded by theRPS5gene.

Ribosomes,the organelles that catalyzeprotein synthesis,ineukaryotes,consist of asmall 40S subunitand alarge 60S subunit(whereasprokaryoticribosomes are 70Svedbergunits, composed of50Sand30Ssubunits). They are located in the cytoplasm. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the eukaryotic 40S subunit. The protein belongs to the S7P family of ribosomal proteins. Variable expression of this gene incolorectal cancerscompared to adjacent normal tissues has been observed, although no correlation between the level ofexpressionand the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenesof this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins".Biochem. Cell Biol.73(11–12): 933–47.doi:10.1139/o95-101.PMID8722009.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank".Gene.150(2): 243–50.doi:10.1016/0378-1119(94)90433-2.PMID7821789.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon".Biochim. Biophys. Acta.1173(3): 273–82.doi:10.1016/0167-4781(93)90124-v.PMID8318536.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996)."Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry".Eur. J. Biochem.239(1): 144–9.doi:10.1111/j.1432-1033.1996.0144u.x.PMID8706699.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002)."Differential expression of genes coding for ribosomal proteins in different human tissues".Bioinformatics.17(12): 1152–7.doi:10.1093/bioinformatics/17.12.1152.PMID11751223.
• Andersen JS, Lyon CE, Fox AH, et al. (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.Bibcode:2002CBio...12....1A.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.S2CID14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002)."The human ribosomal protein genes: sequencing and comparative analysis of 73 genes".Genome Res.12(3): 379–90.doi:10.1101/gr.214202.PMC155282.PMID11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Malygin A, Baranovskaya O, Ivanov A, Karpova G (2003). "Expression and purification of human ribosomal proteins S3, S5, S10, S19, and S26".Protein Expr. Purif.28(1): 57–62.doi:10.1016/S1046-5928(02)00652-6.PMID12651107.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics".Nature.433(7021): 77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID15635413.S2CID4344740.
• Yu Y, Ji H, Doudna JA, Leary JA (2005)."Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes".Protein Sci.14(6): 1438–46.doi:10.1110/ps.041293005.PMC2253395.PMID15883184.

External links

• Overview of all the structural information available in thePDBforUniProt:P46782(40S ribosomal protein S5) at thePDBe-KB.