5-Fluoro-N,N-dimethyltryptamine(5-fluoro-DMT,5F-DMT) is atryptaminederivative related to compounds such as5-bromo-DMTand5-MeO-DMT.[1]Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT2A/Creceptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a psychedelic despite acting as a 5-HT2Aagonist (cf.lisuride), while4-fluoro-5-methoxy-DMTis a much stronger agonist at 5-HT1Athan 5-HT2A.[2][3]
^Chen CY, Senanayake CH, Bill TJ, Larsen RD, Verhoeven TR, Reider PJ (July 1994). "Improved Fischer indole reaction for the preparation of N, N-dimethyltryptamines: Synthesis of L-695,894, a potent 5-HT1D receptor agonist".The Journal of Organic Chemistry.59(13): 3738–3741.doi:10.1021/jo00092a046.
^Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE (November 2000). "Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines".Journal of Medicinal Chemistry.43(24): 4701–10.doi:10.1021/jm000339w.PMID11101361.
^Rabin RA, Regina M, Doat M, Winter JC (May 2002). "5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens".Pharmacology, Biochemistry, and Behavior.72(1–2): 29–37.doi:10.1016/S0091-3057(01)00720-1.PMID11900766.S2CID6480715.
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