6-Chloronicotine

6-Chloronicotine
Identifiers
	IUPAC name 2-chloro-5-[(2S)-1-methylpyrrolidin-2-yl]pyridine;
CAS Number	112091-17-5;
PubChemCID	10631771;
ChemSpider	8807133;
CompTox Dashboard(EPA)	DTXSID90442718;
Chemical and physical data
Formula	C10H13ClN2
Molar mass	196.68g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCC[C@H]1C2=CN=C(C=C2)Cl;
	InChI InChI=1S/C10H13ClN2/c1-13-6-2-3-9(13)8-4-5-10(11)12-7-8/h4-5,7,9H,2-3,6H2,1H3/t9-/m0/s1; Key:SVVOLGNZRGLPIU-VIFPVBQESA-N;

6-Chloronicotineis a drug which acts as anagonistat neuralnicotinic acetylcholine receptors.It substitutes fornicotinein animal studies with around twice the potency, and showsantinociceptiveeffects.^[1]^[2]^[3]^[4]

References

^Dukat M, Fiedler W, Dumas D, Damaj I, Martin BR, Rosecrans JA, James JR, Glennon RA (1996). "Pyrrolidine-modified and 6-substituted analogs of nicotine: A structure—affinity investigation".European Journal of Medicinal Chemistry.31(11): 875–888.doi:10.1016/S0223-5234(97)89850-9.
^Damaj MI, Fei-Yin M, Dukat M, Glassco W, Glennon RA, Martin BR (March 1998). "Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice".The Journal of Pharmacology and Experimental Therapeutics.284(3): 1058–65.PMID 9495867.
^Dukat M, Dowd M, Damaj MI, Martin B, El-Zahabi MA, Glennon RA (1999). "Synthesis, receptor binding and QSAR studies on 6-substituted nicotine derivatives as cholinergic ligands".European Journal of Medicinal Chemistry.34(1): 31–40.doi:10.1016/S0223-5234(99)80038-5.
^Latli B, D'Amour K, Casida JE (June 1999). "Novel and potent 6-chloro-3-pyridinyl ligands for the Alpha 4beta2 neuronal nicotinic acetylcholine receptor".Journal of Medicinal Chemistry.42(12): 2227–34.doi:10.1021/jm980721x.PMID 10377228.

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