60S ribosomal protein L15

RPL15
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4UG0,4V6X,5AJ0,3J7R,4V5Z,4UJD,3J7P,4D67,3J92,4D5Y,3J7Q,4UJE,3J7O,4UJC,%%s3J7R,4V5Z,4V6X,4UJD,3J7P,4D67,3J92,4D5Y,5AJ0,3J7Q,4UG0,4UJE,3J7O,4UJC
Identifiers
Aliases	RPL15,DBA12, EC45, L15, RPL10, RPLY10, RPYL10, ribosomal protein L15
External IDs	OMIM:604174;MGI:1913730;HomoloGene:37713;GeneCards:RPL15;OMA:RPL15 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p24.2 Start 23,916,591bp End 23,924,374bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 A1|14 Start 4,198,305bp End 4,201,873bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in left ovary left testis right testis right ovary germinal epithelium middle temporal gyrus gonad gallbladder canal of the cervix caput epididymis Top expressed in embryo ventricular zone embryo morula blastocyst epiblast yolk sac primitive streak lip Gonadal ridge More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of ribosome cadherin binding RNA binding Cellular component cytosol ribosome membrane intracellular anatomical structure extracellular exosome nucleus cytosolic large ribosomal subunit A band Biological process cytoplasmic translation protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing response to ethanol Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 6138 66480 Ensembl ENSG00000174748 ENSMUSG00000012405 UniProt P61313 Q9CZM2 RefSeq (mRNA) NM_001253379 NM_001253380 NM_001253382 NM_001253383 NM_001253384 NM_002948 NM_025586 NM_001359897 NM_001359899 RefSeq (protein) NP_001240308 NP_001240309 NP_001240311 NP_001240312 NP_001240313 NP_002939 NP_001240308.1 NP_001240309.1 NP_001240311.1 NP_001240312.1 NP_002939.2 NP_079862 NP_001346826 NP_001346828 Location (UCSC) Chr 3: 23.92 – 23.92 Mb Chr 14: 4.2 – 4.2 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L15is aproteinthat in humans is encoded by theRPL15gene.

Ribosomes,theorganellesthat catalyzeprotein synthesis,consist of a small40Ssubunit and a large60Ssubunit. Together these subunits are composed of 4RNAspecies and approximately 80 structurally distinct proteins. This gene encodes aribosomal proteinthat is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in thecytoplasm.This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophagealtumorscompared to normal matched tissues.Transcript variantsutilizing alternativepolyAsignals exist. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenesof this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins".Biochem. Cell Biol.73(11–12): 933–47.doi:10.1139/o95-101.PMID8722009.
• Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes".Nature.355(6361): 632–4.Bibcode:1992Natur.355..632A.doi:10.1038/355632a0.PMID1538749.S2CID4234345.
• Yu W, Andersson B, Worley KC, et al. (1997)."Large-scale concatenation cDNA sequencing".Genome Res.7(4): 353–8.doi:10.1101/gr.7.4.353.PMC139146.PMID9110174.
• Wang Q, Yang C, Zhou J, et al. (2001). "Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer".Gene.263(1–2): 205–9.doi:10.1016/S0378-1119(00)00570-9.PMID11223259.
• Andersen JS, Lyon CE, Fox AH, et al. (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.Bibcode:2002CBio...12....1A.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.S2CID14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002)."The human ribosomal protein genes: sequencing and comparative analysis of 73 genes".Genome Res.12(3): 379–90.doi:10.1101/gr.214202.PMC155282.PMID11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics".Nature.433(7021): 77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID15635413.S2CID4344740.
• Wang H, Zhao LN, Li KZ, et al. (2006)."Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer".BMC Cancer.6:91.doi:10.1186/1471-2407-6-91.PMC1459873.PMID16608517.