ADARB1
Double-stranded RNA-specific editase 1is anenzymethat in humans is encoded by theADARB1gene.[5][6][7]The enzyme is a member ofADARfamily.
Function
[edit]This gene encodes the enzyme responsible forpre-mRNA editingof theglutamate receptor subunit Bby site-specificdeaminationofadenosines.Studies in rats found that this enzyme acted on its ownpre-mRNAmolecules to convert an AAdinucleotideto an AI dinucleotide which resulted in a newsplice site.Alternative splicingof this gene results in several transcript variants, some of which have been characterized by the presence or absence of anAlu cassetteinsert and a short or longC-terminalregion.[7]
ADARB1 requires the small moleculeinositol hexakisphosphate(IP6) for proper function.[8]ADARB1 is anA-to-I RNA-editingenzyme that mostly acts onprotein-codingsubstrates.[9]
See also
[edit]- Adenosine deaminase(ADA), an enzyme acting on isolated adenosine
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000197381–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000020262–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (April 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3".Genomics.41(2): 210–7.doi:10.1006/geno.1997.4655.PMID9143496.
- ^Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004)."Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes".Genome Biology.5(2): 209.doi:10.1186/gb-2004-5-2-209.PMC395743.PMID14759252.
- ^ab"Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".
- ^Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL (September 2005)."Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing".Science.309(5740): 1534–9.Bibcode:2005Sci...309.1534M.doi:10.1126/science.1113150.PMC1850959.PMID16141067.
- ^Licht K, Jantsch MF (April 2016)."Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications".The Journal of Cell Biology.213(1): 15–22.doi:10.1083/jcb.201511041.PMC4828693.PMID27044895.
Further reading
[edit]- Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R (1997). "HIV-1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26".Cellular Peptidases in Immune Functions and Diseases.Advances in Experimental Medicine and Biology. Vol. 421. pp. 185–92.doi:10.1007/978-1-4757-9613-1_24.ISBN978-1-4757-9615-5.PMID9330696.
- Melcher T, Maas S, Herb A, Sprengel R, Seeburg PH, Higuchi M (February 1996). "A mammalian RNA editing enzyme".Nature.379(6564): 460–4.Bibcode:1996Natur.379..460M.doi:10.1038/379460a0.PMID8559253.S2CID4326456.
- O'Connell MA, Gerber A, Keller W (January 1997)."Purification of human double-stranded RNA-specific editase 1 (hRED1) involved in editing of brain glutamate receptor B pre-mRNA".The Journal of Biological Chemistry.272(1): 473–8.doi:10.1074/jbc.272.1.473.PMID8995285.
- Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R (April 1997)."Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles".Journal of Immunology.158(8): 3721–9.doi:10.4049/jimmunol.158.8.3721.PMID9103436.
- Lai F, Chen CX, Carter KC, Nishikura K (May 1997)."Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases".Molecular and Cellular Biology.17(5): 2413–24.doi:10.1128/MCB.17.5.2413.PMC232090.PMID9111310.
- Yang JH, Sklar P, Axel R, Maniatis T (April 1997)."Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing".Proceedings of the National Academy of Sciences of the United States of America.94(9): 4354–9.Bibcode:1997PNAS...94.4354Y.doi:10.1073/pnas.94.9.4354.PMC20726.PMID9113993.
- Gerber A, O'Connell MA, Keller W (May 1997)."Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette".RNA.3(5): 453–63.PMC1369496.PMID9149227.
- Villard L, Tassone F, Haymowicz M, Welborn R, Gardiner K (March 1997). "Map location, genomic organization and expression patterns of the human RED1 RNA editase".Somatic Cell and Molecular Genetics.23(2): 135–45.doi:10.1007/BF02679972.PMID9330641.S2CID45104326.
- Blanco J, Valenzuela A, Herrera C, Lluís C, Hovanessian AG, Franco R (July 2000). "The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression".FEBS Letters.477(1–2): 123–8.doi:10.1016/S0014-5793(00)01751-8.PMID10899322.S2CID22229481.
- Herrera C, Morimoto C, Blanco J, Mallol J, Arenzana F, Lluis C, Franco R (June 2001)."Comodulation of CXCR4 and CD26 in human lymphocytes".The Journal of Biological Chemistry.276(22): 19532–9.doi:10.1074/jbc.M004586200.PMID11278278.
- Maas S, Patt S, Schrey M, Rich A (December 2001)."Underediting of glutamate receptor GluR-B mRNA in malignant gliomas".Proceedings of the National Academy of Sciences of the United States of America.98(25): 14687–92.Bibcode:2001PNAS...9814687M.doi:10.1073/pnas.251531398.PMC64742.PMID11717408.
- Jayan GC, Casey JL (April 2002)."Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2".Journal of Virology.76(8): 3819–27.doi:10.1128/JVI.76.8.3819-3827.2002.PMC136091.PMID11907222.
- Jaikaran DC, Collins CH, MacMillan AM (October 2002)."Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site".The Journal of Biological Chemistry.277(40): 37624–9.doi:10.1074/jbc.M204126200.PMID12163487.
- Jayan GC, Casey JL (December 2002)."Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression".Journal of Virology.76(23): 12399–404.doi:10.1128/JVI.76.23.12399-12404.2002.PMC136899.PMID12414985.
- Slavov D, Gardiner K (October 2002). "Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns".Gene.299(1–2): 83–94.doi:10.1016/S0378-1119(02)01016-8.PMID12459255.
External links
[edit]- HumanADARB1genome location andADARB1gene details page in theUCSC Genome Browser.