Aquaporin-7

AQP7
Identifiers
Aliases	AQP7,AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7
External IDs	OMIM:602974;MGI:1314647;HomoloGene:48000;GeneCards:AQP7;OMA:AQP7 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p13.3 Start 33,383,179bp End 33,402,682bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A5 Start 41,033,074bp End 41,048,139bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in apex of heart subcutaneous adipose tissue left ventricle sural nerve right auricle muscle of thigh lactiferous gland gastric mucosa duodenum quadriceps femoris muscle Top expressed in spermatid seminiferous tubule brown adipose tissue aortic valve white adipose tissue proximal tubule right kidney tunica adventitia of aorta ascending aorta muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycerol channel activity water channel activity channel activity urea transmembrane transporter activity Cellular component cytoplasm integral component of membrane plasma membrane integral component of plasma membrane membrane cell-cell junction lipid droplet cell cortex cytoplasmic vesicle membrane cytoplasmic vesicle Biological process water transport excretion glycerol transport generation of precursor metabolites and energy transmembrane transport urea transmembrane transport Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 364 11832 Ensembl ENSG00000165269 ENSMUSG00000028427 UniProt O14520 O54794 RefSeq (mRNA) NM_001170 NM_001318156 NM_001318157 NM_001318158 NM_001376191 NM_001376192 NM_001376193 NM_007473 RefSeq (protein) NP_001161 NP_001305085 NP_001305086 NP_001305087 NP_001363120 NP_001363121 NP_001363122 NP_031499 NP_001365567 NP_001365568 NP_001365569 NP_001365570 NP_001365571 Location (UCSC) Chr 9: 33.38 – 33.4 Mb Chr 4: 41.03 – 41.05 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin-7(AQP-7) is aproteinthat in humans is encoded by theAQP7gene.

Aquaporins/major intrinsic proteins(MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.

Further reading

• Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport".Proc. Soc. Exp. Biol. Med.219(3): 183–99.doi:10.3181/00379727-219-44332.PMID9824541.S2CID28952956.
• Kuriyama H, Kawamoto S, Ishida N, et al. (1998). "Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability".Biochem. Biophys. Res. Commun.241(1): 53–8.doi:10.1006/bbrc.1997.7769.PMID9405233.
• Ishibashi K, Yamauchi K, Kageyama Y, et al. (1998). "Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping".Biochim. Biophys. Acta.1399(1): 62–6.doi:10.1016/s0167-4781(98)00094-3.PMID9714739.
• Suzuki-Toyota F, Ishibashi K, Yuasa S (1999). "Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis".Cell Tissue Res.295(2): 279–85.doi:10.1007/s004410051234.PMID9931374.S2CID30916397.
• Kondo H, Shimomura I, Kishida K, et al. (2002)."Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation".Eur. J. Biochem.269(7): 1814–26.doi:10.1046/j.1432-1033.2002.02821.x.PMID11952783.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004)."DNA sequence and analysis of human chromosome 9".Nature.429(6990): 369–74.Bibcode:2004Natur.429..369H.doi:10.1038/nature02465.PMC2734081.PMID15164053.
• Fortna A, Kim Y, MacLaren E, et al. (2006)."Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution".PLOS Biol.2(7): E207.doi:10.1371/journal.pbio.0020207.PMC449870.PMID15252450.
• Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ (2006). "Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers".Biochem. Biophys. Res. Commun.339(3): 785–9.doi:10.1016/j.bbrc.2005.11.080.PMID16325777.
• Prudente S, Flex E, Morini E, et al. (2007)."A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities".Diabetes.56(5): 1468–74.doi:10.2337/db06-1389.PMID17351148.
• Ceperuelo-Mallafré V, Miranda M, Chacón MR, et al. (2007)."Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes".J. Clin. Endocrinol. Metab.92(9): 3640–5.doi:10.1210/jc.2007-0531.PMID17566090.

External links

• AQP7+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
• HumanAQP7genome location andAQP7gene details page in theUCSC Genome Browser.
• HumanAQP9genome location andAQP9gene details page in theUCSC Genome Browser.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.