Adrian V. S. Hill
Sir Adrian Hill | |
|---|---|
| Born | 9 October 1958 |
| Education | Belvedere College |
| Alma mater | |
| Known for | Vaccinology |
| Spouses | |
| Scientific career | |
| Fields | Genetics Immunology Vaccines Malaria[1] |
| Institutions | |
| Thesis | The distribution and molecular basis of thalassaemia in Oceania(1986) |
| Doctoral advisor | John Brian Clegg David Weatherall |
| Website | www |
Sir Adrian Vivian Sinton Hill,KBEFRSFMedSciFRCP(born 9 October 1958)[2]is a British-Irish vaccinologist who is Director of theJenner Instituteand Lakshmi Mittal and Family Professor of Vaccinology at theUniversity of Oxford,an honorary Consultant Physician in Infectious Diseases,[3]andFellowofMagdalen College, Oxford.[4]Hill is a leader in the field of malaria vaccine development and was a co-leader of the research team which produced theOxford–AstraZeneca COVID-19 vaccine,along with ProfessorSarah Gilbertof the Jenner Institute and ProfessorAndrew Pollardof theOxford Vaccine Group.[5][1][6]
Early life and education[edit]
Hill was educated atBelvedere Collegein Dublin.[2]He began reading medicine atTrinity College Dublin,where he was elected aFoundation Scholarin 1978.[7]Thereupon he transferred toMagdalen College, Oxfordfor one year, but he ended up remaining in Oxford to complete the rest of his medical degree, qualifying in 1982.[8][4]He remained at theUniversity of Oxfordfor postgraduate studies and was awarded aDoctor of Philosophydegree in 1986[9]for research on the molecular genetics ofthalassemiasupervised byJohn B. Clegg.[4][10]
Career and research[edit]
During his time at theWellcome Trust Centre for Human Geneticshis research group studied genetic susceptibility to infections such asmalaria,tuberculosis,andHIV.From 1997[11]he has developed candidate vaccines for malaria which produce cellular (T-cell) immunity and partial efficacy usingAdenovirusandModified vaccinia Ankara(MVA) viral vector vaccines in a prime-boost regime.[12]From 2005 he has played a leading role in the pre-clinical and clinical assessment of new chimpanzee adenoviral vaccine vectors, particularly ChAd63, ChAd3 and ChAdOx1.
His group has developed numerous candidate vaccines against malaria which have been tested inclinical trialsin the UK and Africa.[13]In 2021 his group reported high efficacy of a new R21/matrix-M candidate vaccine in Burkina Faso children and this vaccine is now in a phase III licensure trial.[14]In 2014, he led a clinical trial of anEbolavaccine based on chimpanzee adenoviral and MVA vector technology in response to theWest African Ebola virus epidemic.[12][15][16]In 2016 he co-founded Vaccitech plc, an OxfordUniversity spin-offcompany developing therapeutic and preventive vaccines based on viral vector technology.[17]In 2017 he led a successful major award application to Innovate UK to co-found the Vaccines Manufacturing and Innovation Centre (VMIC) in Harwell, Oxfordshire, one of the first purpose-built vaccine manufacturing centres for emergency response vaccines.[18]In response to the 2020 COVID-19 pandemic he worked with many others at Oxford to develop and partner the ChAdOx1 vector-based SARS-CoV-2 vaccine, notably with AstraZeneca and the Serum Institute of India, supporting large scale access for low and middle income countries.[19]
Honours and awards[edit]
- 1999 Elected aFellow of the Royal College of Physicians(FRCP)[2][20]
- 1999 Elected aFellow of the Academy of Medical Sciences(FMedSci)[2][20]
- 2005 Appointed to a Fellowship by Special Election at Magdalen College, Oxford[4]
- 2005 Founded theJenner Instituteat Oxford University and appointed institute Director[21]
- 2008 Elected an Honorary Fellow ofTrinity College Dublin(Hon. FTCD)[8]
- 2020 Appointed to an ad hominen Lakshmi Mittal and Family Professorship of Vaccinology at Oxford University[22]
- 2021 Elected a Fellow of theRoyal Society[23]
- 2021 Appointed an Honorary Knight Commander of theOrder of the British Empire(KBE) in the2021 Birthday Honours.[24]Made substantive in 2023, which means he can use both the title of 'Sir' and 'KBE'. Prior to this, only thepostnominal letterswere allowed to be used.[25]
Personal life[edit]
Hill has two children with his former wife, epidemiologistSunetra Gupta.
In 2021, he marriedSabina Murray.[2]
References[edit]
- ^abAdrian V. S. Hillpublications indexed byGoogle Scholar
- ^abcdeAnon (2020)."Hill, Prof. Adrian Vivian Sinton".Who's Who.A & C Black.doi:10.1093/ww/9780199540884.013.U59812.(Subscription orUK public library membershiprequired.)
- ^"Adrian Hill".ndm.ox.ac.uk.Retrieved20 July2021.
- ^abcd"Professor Adrian Hill, Fellow by Special Election".magd.ox.ac.uk.Retrieved5 June2022.
- ^"Oxford University academics recognised in Queen's Birthday Honours | University of Oxford".ox.ac.uk.11 June 2021.Retrieved20 July2021.
- ^Adrian V. S. Hillpublications fromEurope PubMed Central
- ^"List of scholars - Scholars - TCD".tcdlife.ie.Retrieved20 July2021.
- ^ab"Fellows and Scholars 2008".Trinity College Dublin.Retrieved23 August2020.
- ^Hill, Adrian Vivian Sinton (1986).The distribution and molecular basis of thalassaemia in Oceania.bodleian.ox.ac.uk(DPhil thesis). University of Oxford.OCLC59703987.EThOSuk.bl.ethos.375250.
- ^"Professor Adrian Hill".oxfordmartin.ox.ac.uk.Oxford Martin School. Archived fromthe originalon 1 February 2016.Retrieved25 January2016.
- ^Schneider, J.; Gilbert, S. C.; Blanchard, T. J.; Hanke, T.; Robson, K. J.; Hannan, C. M.; Becker, M.; Sinden, R.; Smith, G. L.; Hill, A. V. (1998)."Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara".Nature Medicine.4(4): 397–402.doi:10.1038/nm0498-397.PMID9546783.S2CID11413461.
- ^ab"Professor Adrian VS Hill - Nuffield Department of Medicine".ndm.ox.ac.uk.Retrieved25 January2016.
- ^"Adrian Hill: Malaria Vaccines - Nuffield Department of Medicine".ndm.ox.ac.uk.Archived fromthe originalon 11 January 2016.Retrieved25 January2016.
- ^Datoo, M. S.; et al. (May 2021)."Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial".Lancet.397(10287): 1809–1818.doi:10.1016/S0140-6736(21)00943-0.PMC8121760.PMID33964223.
- ^University of Oxford (11 March 2016),Oxford London Lecture 2016: Vaccines for Ebola: Tackling a Market Failure,retrieved17 February2018
- ^Oxford Martin School (26 November 2015),Prevent and protect: vaccines and immune responses,retrieved17 February2018
- ^"Our Team - Vaccitech".vaccitech.co.uk.Retrieved17 February2018.
- ^"Dramatic increase in the UK vaccine capability".3 December 2018.
- ^"Meet the Irish scientist behind Oxford's coronavirus vaccine".IrishCentral.21 July 2020.Retrieved11 October2020.
- ^ab"Accelerating vaccine development".royalsociety.org.Retrieved17 February2018.
- ^"Adrian Hill".theconversation.The Conversation.8 August 2013.Retrieved17 February2018.
- ^"Future of Oxford professorship in vaccinology secured with £3.5 million gift University of Oxford".
- ^"Oxford Researchers elected to Royal Society | University of Oxford".ox.ac.uk.7 May 2021.Retrieved8 May2021.
- ^"Honorary Awards to Foreign Nationals in 2021".Gov.UK. 2021.
- ^"No. 63999".The London Gazette.17 March 2023. p. 5218.
| International | |
|---|---|
| National | |
| Academics | |
| Other | |
- 20th-century British medical doctors
- 21st-century British medical doctors
- 1958 births
- Living people
- People educated at Belvedere College
- Scholars of Trinity College Dublin
- Alumni of Magdalen College, Oxford
- Academics of the University of Oxford
- Fellows of the Academy of Medical Sciences (United Kingdom)
- Fellows of the Royal Society
- Irish knights
- Knights Commander of the Order of the British Empire
- Naturalised citizens of the United Kingdom
- People from Dublin (city)
- NIHR Senior Investigators
- Vaccinologists