Alopecia totalis
| Alopecia totalis | |
|---|---|
 | |
| A woman with alopecia totalis | |
| Specialty | Dermatology |
Alopecia totalisis the loss of allhairon theheadandface.Its causes are unclear, but believed to beautoimmune.Research suggests there may be a genetic component linked to developing alopecia totalis; the presence of DRB1*0401 and DQB1*0301, both of which arehuman leukocyte antigens(HLA), were found to be associated with long-standing alopecia totalis.[1]
Treatment[edit]
Methotrexateandcorticosteroidsare proposed treatments.[2]
Scalp cooling has specifically been used to prevent alopecia indocetaxelchemotherapy,[3]although it has been found prophylactic in other regimens as well.[4][5][6]Treatment effects may take time to resolve, with one study showing breast cancer survivors wearing wigs up to 2 years after chemotherapy.[7]
See also[edit]
References[edit]
- ^Colombe, Beth W.; Lou, Calvin D.; Price, Vera H. (December 1999)."The Genetic Basis of Alopecia Areata: HLA Associations with Patchy Alopecia Areata Versus Alopecia Totalis and Alopecia Universalis".Journal of Investigative Dermatology Symposium Proceedings.4(3): 216–219.doi:10.1038/sj.jidsp.5640214.ISSN1087-0024.PMID10674369.
- ^Joly, Pascal (2006). "The use of methtrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis".Journal of the American Academy of Dermatology.55(4): 632–6.doi:10.1016/j.jaad.2005.09.010.PMID17010743.
- ^Hurk, C. J. G.; Breed, W. P. M.; Nortier, J. W. R. (2012). "Short post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia".Supportive Care in Cancer.20(12): 3255–3260.doi:10.1007/s00520-012-1465-0.PMID22539051.S2CID1282047.
- ^Lemieux, J. (2012). "Reducing chemotherapy-induced alopecia with scalp cooling".Clinical Advances in Hematology & Oncology.10(10): 681–682.PMID23187775.
- ^Van Den Hurk, C. J.; Peerbooms, M.; Van De Poll-Franse, L. V.; Nortier, J. W.; Coebergh, J. W. W.; Breed, W. P. (2012). "Scalp cooling for hair preservation and associated characteristics in 1411 chemotherapy patients - Results of the Dutch Scalp Cooling Registry".Acta Oncologica.51(4): 497–504.doi:10.3109/0284186X.2012.658966.PMID22304489.S2CID26709009.
- ^Yeager, C. E.; Olsen, E. A. (2011). "Treatment of chemotherapy-induced alopecia".Dermatologic Therapy.24(4): 432–442.doi:10.1111/j.1529-8019.2011.01430.x.PMID21910801.S2CID45148677.
- ^Oshima, Y.; Watanabe, T.; Nakagawa, S.; Endo, A.; Shiga, C. (2012). "A questionnaire survey about hair loss after chemotherapy for breast cancer".Gan to Kagaku Ryoho. Cancer & Chemotherapy.39(9): 1375–1378.PMID22996772.