Aquaporin-3
(Redirected fromAquaporin 3)
Aquaporin 3(AQP-3) is the protein product of the humanAQP3gene.[5]It is found in the basolateral cell membrane of principalcollecting ductcells and provides a pathway for water to exit these cells.[6]Aquaporin-3 is also permeable toglycerol,ammonia,urea,andhydrogen peroxide.It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers.[7]In the kidney, aquaproin-3 is unresponsive to the antidiuretic hormonevasopressin,unlikeaquaporin-2.[8]This protein is also a determinant for the GIL blood group system.[9]
Suberoylanilide hydroxamic acid(SAHA) (aHDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).[10]
Clinical significance
[edit]Aquaporin 3 levels are often lower inpsoriasisthan in healthy skin.[10]
Aquaporin 3 is expressed more inatopic eczema.[11]
Recent studies indicate that aquaporin 3 is overexpressed in many types of malignancies such asmelanoma[7]andprimary effusion lymphomas[12]as well as cancers of the lung, colon, stomach, esophagus, mouth, liver, and pancreatic duct.[5][12]Based on these as well ascell culturestudies, it is suggested that this overexpression contributes to the growth and spread of at least some of these cancers and therefore may be a therapeutic target for the treatment of these cancers.[5][7][12]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000165272–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000028435–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^abcMarlar S, Jensen HH, Login FH, Nejsum LN (October 2017)."Aquaporin-3 in Cancer".International Journal of Molecular Sciences.18(10): 2106.doi:10.3390/ijms18102106.PMC5666788.PMID28991174.
- ^Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct".Annu. Rev. Physiol.60:199–220.doi:10.1146/annurev.physiol.60.1.199.PMID9558461.
- ^abcOliveira Pinho J, Matias M, Gaspar MM (October 2019)."Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma".Nanomaterials.9(10): 1455.doi:10.3390/nano9101455.PMC6836019.PMID31614947.
- ^Dibas AI, Mia AJ, Yorio, T (1998). "Aquaporins (Water Channels): Role in Vasopressin-Activated Water Transport".Proc. Soc. Exp. Biol. Med.219(3): 183–99.doi:10.3181/00379727-219-44332.PMID9824541.S2CID28952956.
- ^Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002)."AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL".J. Biol. Chem.277(48): 45854–9.doi:10.1074/jbc.M208999200.PMID12239222.
- ^abUniversity, Medical College of Georgia at Augusta."Cancer therapy shows promise for psoriasis treatment".medicalxpress.
- ^Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema".Allergy.61(9): 1132–7.doi:10.1111/j.1398-9995.2006.01151.x.PMID16918518.S2CID7873440.
- ^abcShimada K, Hayakawa F, Kiyoi H (November 2018)."Biology and management of primary effusion lymphoma".Blood.132(18): 1879–1888.doi:10.1182/blood-2018-03-791426.PMID30154110.
Further reading
[edit]- Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte".Mol. Biochem. Parasitol.167(1): 48–53.doi:10.1016/j.molbiopara.2009.04.006.PMID19393693.
- Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations".Transfusion.48(6): 1164–8.doi:10.1111/j.1537-2995.2008.01683.x.PMID18435676.S2CID5795042.
- Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture".J. Soc. Gynecol. Investig.13(3): 181–5.doi:10.1016/j.jsgi.2006.02.002.PMID16638588.S2CID30438043.
- Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells".Respiratory Physiology & Neurobiology.161(2): 111–8.doi:10.1016/j.resp.2007.12.007.PMID18280225.S2CID25006640.
- Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine".Biochem. Biophys. Res. Commun.373(4): 613–7.doi:10.1016/j.bbrc.2008.06.086.PMID18601899.
- Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor- Alpha decreases aquaporin-3 expression in DJM-1 keratinocytes".Biochem. Biophys. Res. Commun.387(3): 564–8.doi:10.1016/j.bbrc.2009.07.077.PMID19619514.
- Bellemère G, Von Stetten O, Oddos T (2008)."Retinoic acid increases aquaporin 3 expression in normal human skin".J. Invest. Dermatol.128(3): 542–8.doi:10.1038/sj.jid.5701047.PMID17943189.
- Cohly HH, Isokpehi R, Rajnarayanan RV (2008)."Compartmentalization of aquaporins in the human intestine".Int J Environ Res Public Health.5(2): 115–9.doi:10.3390/ijerph5020115.PMC2694936.PMID18678926.
- Lee TC, Ho IC, Lu WJ, Huang JD (2006)."Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line".J. Biol. Chem.281(27): 18401–7.doi:10.1074/jbc.M601266200.PMID16672223.
- Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing".J. Mol. Med.86(2): 221–31.doi:10.1007/s00109-007-0272-4.PMID17968524.S2CID24532416.
- Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009)."The expression of differentiation markers in aquaporin-3 deficient epidermis".Arch. Dermatol. Res.301(3): 245–52.doi:10.1007/s00403-009-0927-9.PMC3582396.PMID19184071.
- Wang J, Tanji N, Kikugawa T, et al. (2007)."Expression of aquaporin 3 in the human prostate".Int. J. Urol.14(12): 1088–92, discussion 1092.doi:10.1111/j.1442-2042.2007.01901.x.PMID18036046.S2CID34913820.
- Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin".J. Cell. Biochem.102(4): 1051–8.doi:10.1002/jcb.21350.PMID17471492.S2CID7045806.
- Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF- Alpha -mediated proinflammatory events: Implication in periodontal inflammation".J. Cell. Physiol.217(2): 338–49.doi:10.1002/jcp.21506.PMID18543247.S2CID900588.
- Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc".J. Mol. Histol.39(3): 303–9.doi:10.1007/s10735-008-9166-1.PMID18247144.S2CID24136257.
- Avril-Delplanque A, Casal I, Castillon N, et al. (2005)."Aquaporin-3 expression in human fetal airway epithelial progenitor cells".Stem Cells.23(7): 992–1001.doi:10.1634/stemcells.2004-0197.PMID16043462.S2CID31421283.
- Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line".J. Membr. Biol.208(1): 55–64.doi:10.1007/s00232-005-0819-7.PMID16596446.S2CID11479553.
- Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues".Hum. Pathol.38(1): 171–8.doi:10.1016/j.humpath.2006.07.015.PMID17056099.
External links
[edit]- GIL blood group systematBGMUTBlood Group Antigen Gene Mutation Database atNCBI,NIH
- HumanAQP3genome location andAQP3gene details page in theUCSC Genome Browser.