Artemotil

Artemotil
Clinical data
AHFS/Drugs	International Drug Names
Pregnancy; category	not available;
Routes of; administration	Intramuscular injection
ATC code	P01BE04(WHO);
Pharmacokineticdata
Metabolism	Hepatic
Eliminationhalf-life	20 hours
Identifiers
	IUPAC name (5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
CAS Number	75887-54-6;
PubChemCID	3000469;
ChemSpider	2272064;
UNII	XGL7GFB9YI;
ChEMBL	ChEMBL301267;
Chemical and physical data
Formula	C17H28O5
Molar mass	312.406g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCO[C@@H]1[C@@H]([C@@H]2CC[C@H]([C@H]3[C@]24[C@H](O1)O[C@@](CC3)(OO4)C)C)C;
	InChI InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1; Key:NLYNIRQVMRLPIQ-XQLAAWPRSA-N;
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Artemotil(INN;also known asβ-arteether^[1]), is a fast acting bloodschizonticidespecifically indicated for the treatment ofchloroquine-resistantPlasmodium falciparummalariaandcerebral malariacases.^[2]It is a semi-synthetic derivative ofartemisinin,anatural productof the Chinese plantArtemisia annua.It is currently only used as a second line drug in severe cases of malaria.

References

^"The International Pharmacopoeia - Sixth Edition - Artemotil"(PDF).2016.Retrieved10 April2019.
^Yeates RA (April 2002). "Artemotil Artecef".Current Opinion in Investigational Drugs.3(4). London, England: 545–9.PMID 12090721.

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