Avram Hershko
Avram Hershko | |
|---|---|
 Hershko in 1994 | |
| Born | Ferenc Ábrahám Herskó December 31, 1937 |
| Nationality |
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| Alma mater | Hebrew University of Jerusalem |
| Known for | Ubiquitin-mediatedprotein degradation |
| Spouse |
Judith Leibowitz (m.1963) |
| Children | 3 |
| Awards | Weizmann Prize(1987) Nobel Prize in Chemistry(2004) |
| Scientific career | |
| Fields | Chemistry |
| Institutions | Technion,Haifa |
Avram Hershko(Hebrew:אברהם הרשקו,romanized:Avraham Hershko,Hungarian:Herskó Ferenc Ábrahám;[1]born December 31, 1937) is a Hungarian-Israelibiochemistwho received theNobel Prize in Chemistryin 2004.
Biography[edit]
He was bornHerskó FerencinKarcag,Hungary,into aJewishfamily,[2]the son of Shoshana/Margit 'Manci' (née Wulc) and Moshe Hershko, both teachers.[3] During theSecond World War,his father was forced intolabor service in the Hungarian armyand then taken as a prisoner by theSoviet Army.For years, Avram's family didn't known anything about what had happened to his father. Avram, his mother and older brother Chaim/Laszlo 'Laci' were put in aghettoinSzolnok.During the final days of the ghetto, most Jews were sent to be murdered inAuschwitz,but Avram and his family managed to board trains that took them to aconcentration campinAustria,where they were forced into labor until the end of the war. Avram and his mother and brother survived the war and returned to their home. His father returned as well, 4 years after they had last seen him.[4]
Hershko and his family emigrated to Israel in 1950 and settled inJerusalem.He received his MD in 1965 and his PhD in 1969 from theHebrew University of Jerusalem-Hadassah Medical Center.He was apostdoctoral scholarat theUniversity of California, San Francisco.He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at theTechnioninHaifaand a Distinguished Adjunct Professor at theNew York University Grossman School of Medicine.
Along withAaron CiechanoverandIrwin Rose,he was awarded the 2004Nobel Prize in Chemistryfor the discovery ofubiquitin-mediatedprotein degradation.The ubiquitin-proteasomesystem has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as cancer, muscular and neurological diseases, and immune and inflammatory responses.
His contributions to science directly helped cure one of his long-time friends of cancer.[5]
Honours and awards[edit]
- 1987 –Weizmann Prize for Sciences[citation needed]
- 1994 –Israel Prizein Biochemistry[6]
- 1999 –Canada Gairdner International Award(withAlexander Varshavsky)
- 2000 –Albert Lasker Award for Basic Medical Research(withAaron Ciechanoverand Varshavsky)
- 2000 –Alfred P. Sloan Jr. Prize(with Varshavsky)
- 2000 – Member,Israel Academy of Sciences and Humanities
- 2001 –Louisa Gross Horwitz PrizefromColumbia University(with Varshavsky)
- 2001 –Massry Prizefrom theKeck School of Medicine of USC,University of Southern California(with Varshavsky)
- 2001 –Wolf Prize in Medicine(with Varshavsky) for "the discovery of theubiquitinsystem of intracellularprotein degradationand the crucial functions of this system in cellular regulation. "[7]
- 2002 –The EMET Prize for Art, Science and Culturein the category of Life Sciences (with Ciechanover andLeo Sachs)
- 2002 –E.B. Wilson Medal(with Varshavsky)
- 2003 – Foreign Associate,National Academy of Sciences,USA
- 2004 – Nobel Prize in Chemistry for his discovery with Ciechanover andIrwin Rose,of ubiquitin-mediated protein degradation[8]
- 2005 – Elected to theAmerican Philosophical Society[9]
Publications[edit]
- Hershko, A.; Ciechanover, A.; Heller, H.; Haas, A. L.; Rose, I. A. (April 1, 1980)."Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis".Proceedings of the National Academy of Sciences.77(4): 1783–1786.Bibcode:1980PNAS...77.1783H.doi:10.1073/pnas.77.4.1783.ISSN0027-8424.PMC348591.PMID6990414.
- Hershko, A; Heller, H; Elias, S; Ciechanover, A (July 10, 1983)."Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown".The Journal of Biological Chemistry.258(13): 8206–14.doi:10.1016/S0021-9258(20)82050-X.ISSN0021-9258.PMID6305978.
- Hershko, A.; Leshinsky, E.; Ganoth, D.; Heller, H. (March 1, 1984)."ATP-dependent degradation of ubiquitin-protein conjugates".Proceedings of the National Academy of Sciences.81(6): 1619–1623.Bibcode:1984PNAS...81.1619H.doi:10.1073/pnas.81.6.1619.ISSN0027-8424.PMC344969.PMID6324208.
- Hershko, A; Heller, H; Eytan, E; Reiss, Y (1986)."The protein substrate binding site of the ubiquitin-protein ligase system".Journal of Biological Chemistry.261(26). Elsevier BV: 11992–11999.doi:10.1016/s0021-9258(18)67192-3.ISSN0021-9258.PMID3017957.
- Ganoth, D; Leshinsky, E; Eytan, E; Hershko, A (September 5, 1988)."A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation".The Journal of Biological Chemistry.263(25): 12412–9.doi:10.1016/S0021-9258(18)37771-8.ISSN0021-9258.PMID2842333.
- Sudakin, V; Ganoth, D; Dahan, A; Heller, H; Hershko, J; Luca, F C; Ruderman, J V; Hershko, A (1995)."The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis".Molecular Biology of the Cell.6(2). American Society for Cell Biology (ASCB): 185–197.doi:10.1091/mbc.6.2.185.ISSN1059-1524.PMC275828.PMID7787245.
Involvement with biotechnology[edit]
Hershko serves on the Scientific Advisory Board ofOramed Pharmaceuticals.[10]
See also[edit]
- List of Israel Prize recipients
- List of Israeli Nobel laureates
- List of Jewish Nobel laureates
- Science and technology in Israel
- Raz Hershko(born 1998), Israeli European champion and Olympic judoka
References[edit]
- ^"Hungary's Nobel Prize Winners".mta.hu.Archived fromthe originalon October 6, 2015.RetrievedSeptember 22,2021.
- ^JINFO."Jewish Nobel Prize Winners in Chemistry".jinfo.org.RetrievedMarch 30,2023.
- ^Avram Hershkoon Nobelprize.orgincluding the Nobel LectureThe Ubiquitin System for Protein Degradation and some of its Roles in the Control of the Cell Division Cycle
- ^"אברהם הרשקו".
- ^Friedman, Sally (September 13, 2011)."Nobel Prize winner's discovery helps save longtime physician friend".Burlington County Times.phillyBurbs. Archived fromthe originalon September 13, 2012.RetrievedMay 15,2012.
- ^"Israel Prize Official Site – Recipients in 1994"(in Hebrew). Archived fromthe originalon December 27, 2008.
- ^"Wolf Prize Recipients in Medicine".Archived fromthe originalon February 26, 2009.
- ^Iddo Genuth (July 29, 2005)."Two Israeli Scientists Have Won The Nobel Prize In Chemistry".isracast.Archived fromthe originalon December 19, 2005.
- ^"APS Member History".search.amphilsoc.org.RetrievedJune 8,2021.
- ^"Nobel Laureate, Oramed SAB member Prof. Avram Hershko and Oramed CSO Dr. Miriam Kidron to be Featured on Biotalknology Webinar" Oral Delivery of Therapeutic Proteins – Oramed Story "on November 18, 2020".Oramed Pharmaceuticals.November 18, 2020.RetrievedJuly 15,2023.
External links[edit]
- Avram Hershkoon Nobelprize.orgincluding the Nobel LectureThe Ubiquitin System for Protein Degradation and some of its Roles in the Control of the Cell Division Cycle
- Website at the Technion
- Avram Hershko's Short Talk: "Lessons from My Life in Science"
- "Hungarian" Nobel Prize winnersCrooked Timber
- Avram HershkoJewish Virtual Library
- Ubiquitin-Mediated Protein Degradation: From the lab to the bedsideDan Hersko
- The Official Site of Louisa Gross Horwitz Prize
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Italicsindicate a Nobel Memorial Prize, i.e. not one of the original Prizes bequested byAlfred Nobel. |
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- 1937 births
- Living people
- Nobel laureates in Chemistry
- Hungarian Nobel laureates
- Israeli Nobel laureates
- The Hebrew University-Hadassah Medical School alumni
- Hungarian biochemists
- Hungarian emigrants to Israel
- Hungarian Jews
- Israel Prize in biochemistry recipients
- EMET Prize recipients in the Life Sciences
- Israeli biochemists
- Israeli Jews
- Members of the European Molecular Biology Organization
- Members of the Israel Academy of Sciences and Humanities
- Foreign associates of the National Academy of Sciences
- Foreign members of the Chinese Academy of Sciences
- Scientists from Haifa
- People from Karcag
- Academic staff of Technion – Israel Institute of Technology
- Wolf Prize in Medicine laureates
- Recipients of the Albert Lasker Award for Basic Medical Research
- Massry Prize recipients
- Schleiden Medal recipients
- Jewish concentration camp survivors
- Israeli people of Hungarian-Jewish descent
- Members of the American Philosophical Society
- New York University faculty
- University of California, San Francisco alumni
- Weizmann Prize recipients