BCAS3
Appearance
Breast carcinoma amplified sequence 3,also known asBCAS3,is aproteinwhich in humans is encoded by theBCAS3gene.[5][6]BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.[6]
Function
[edit]The BCAS3 gene is regulated byestrogen receptor Alpha(ER-α).[7]ThePELP1protein acts as a transcriptionalcoactivatorof estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesseshistone acetyltransferaseactivity and itself appears to act as a coactivator of ER-α.[8]Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in apositive feedbackloop leading to ER-α mediated signal amplification.[8]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000141376–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000059439–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Entrez Gene: BCAS3 breast carcinoma amplified sequence 3".
- ^abBärlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A (December 2002). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer".Genes Chromosomes Cancer.35(4): 311–7.doi:10.1002/gcc.10121.PMID12378525.S2CID9759638.
- ^Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R (April 2006)."MTA1, a transcriptional activator of breast cancer amplified sequence 3".Proc. Natl. Acad. Sci. U.S.A.103(17): 6670–5.Bibcode:2006PNAS..103.6670G.doi:10.1073/pnas.0601989103.PMC1458939.PMID16617102.
- ^abGururaj AE, Peng S, Vadlamudi RK, Kumar R (August 2007)."Estrogen induces expression of BCAS3, a novel estrogen receptor- Alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)".Mol. Endocrinol.21(8): 1847–60.doi:10.1210/me.2006-0514.PMID17505058.(Retracted, seedoi:10.1210/me.2014-1149,Retraction Watch )
External links
[edit]- HumanBCAS3genome location andBCAS3gene details page in theUCSC Genome Browser.
Further reading
[edit]- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
- Bärlund M, Monni O, Weaver JD, et al. (2003). "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer".Genes Chromosomes Cancer.35(4): 311–7.doi:10.1002/gcc.10121.PMID12378525.S2CID9759638.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID16344560.
- Gururaj AE, Singh RR, Rayala SK, et al. (2006)."MTA1, a transcriptional activator of breast cancer amplified sequence 3".Proc. Natl. Acad. Sci. U.S.A.103(17): 6670–5.Bibcode:2006PNAS..103.6670G.doi:10.1073/pnas.0601989103.PMC1458939.PMID16617102.
- Gururaj AE, Holm C, Landberg G, Kumar R (2006)."Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer".Cell Cycle.5(13): 1407–10.doi:10.4161/cc.5.13.2924.PMID16855396.
- Gururaj AE, Peng S, Vadlamudi RK, Kumar R (2007)."Estrogen induces expression of BCAS3, a novel estrogen receptor- Alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)".Mol. Endocrinol.21(8): 1847–60.doi:10.1210/me.2006-0514.PMID17505058.(Retracted, seedoi:10.1210/me.2014-1149,Retraction Watch )