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Chemical compound
BHF-177 |
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N-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl]-2-methyl-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinamine
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| Formula | C19H20F3N3 |
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| Molar mass | 347.385g·mol−1 |
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| 3D model (JSmol) | |
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Cc3nc(N[C@@H]2C[C@H]1CC[C@@H]2C1)c(cn3)c4ccc(cc4)C(F)(F)F
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InChI=1S/C19H20F3N3/c1-11-23-10-16(13-4-6-15(7-5-13)19(20,21)22)18(24-11)25-17-9-12-2-3-14(17)8-12/h4-7,10,12,14,17H,2-3,8-9H2,1H3,(H,23,24,25)/t12-,14+,17+/m0/s1  YKey:ADHZHPOKTRHZGT-DXCKQFNASA-N Y
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BHF-177is a compound used in scientific research which acts as apositive allosteric modulatorat theGABABreceptor.[1]It was shown to reduce self-administration ofnicotinein animal studies.[2]
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| Ionotropic | | GABAATooltip γ-Aminobutyric acid A receptor |
- Positive modulators (abridged; seeherefor a full list):α-EMTBL
- Alcohols(e.g.,drinking alcohol,2M2B)
- Anabolic steroids
- Avermectins(e.g.,ivermectin)
- Barbiturates(e.g.,phenobarbital)
- Benzodiazepines(e.g.,diazepam)
- Bromidecompounds (e.g.,potassium bromide)
- Carbamates(e.g.,meprobamate)
- Carbamazepine
- Chloralose
- Chlormezanone
- Clomethiazole
- Dihydroergolines(e.g.,ergoloid (dihydroergotoxine))
- Etazepine
- Etifoxine
- Fenamates(e.g.,mefenamic acid)
- Flavonoids(e.g.,apigenin,hispidulin)
- Fluoxetine
- Flupirtine
- Imidazoles(e.g.,etomidate)
- Kavaconstituents (e.g.,kavain)
- Lanthanum
- Loreclezole
- Monastrol
- Neuroactive steroids(e.g.,allopregnanolone,cholesterol,THDOC)
- Niacin
- Niacinamide
- Nonbenzodiazepines(e.g.,β-carbolines(e.g.,abecarnil),cyclopyrrolones(e.g.,zopiclone),imidazopyridines(e.g.,zolpidem),pyrazolopyrimidines(e.g.,zaleplon))
- Norfluoxetine
- Petrichloral
- Phenols(e.g.,propofol)
- Phenytoin
- Piperidinediones(e.g.,glutethimide)
- Propanidid
- Pyrazolopyridines(e.g.,etazolate)
- Quinazolinones(e.g.,methaqualone)
- Retigabine (ezogabine)
- ROD-188
- Skullcapconstituents (e.g.,baicalin)
- Stiripentol
- Sulfonylalkanes(e.g.,sulfonmethane (sulfonal))
- Topiramate
- Valerianconstituents (e.g.,valerenic acid)
- Volatiles/gases(e.g.,chloral hydrate,chloroform,diethyl ether,paraldehyde,sevoflurane)
- Negative modulators:1,3M1B
- 3M2B
- 11-Ketoprogesterone
- 17-Phenylandrostenol
- α3IA
- α5IA (LS-193,268)
- β-CCB
- β-CCE
- β-CCM
- β-CCP
- β-EMGBL
- Anabolic steroids
- Amiloride
- Anisatin
- β-Lactams(e.g.,penicillins,cephalosporins,carbapenems)
- Basmisanil
- Bemegride
- Bicyclic phosphates(TBPS,TBPO,IPTBO)
- BIDN
- Bilobalide
- Bupropion
- CHEB
- Chlorophenylsilatrane
- Cicutoxin
- Cloflubicyne
- Cyclothiazide
- DHEA
- DHEA-S
- Dieldrin
- (+)-DMBB
- DMCM
- DMPC
- EBOB
- Etbicyphat
- FG-7142 (ZK-31906)
- Fiproles(e.g.,fipronil)
- Flavonoids(e.g.,amentoflavone,oroxylin A)
- Flumazenil
- Fluoroquinolones(e.g.,ciprofloxacin)
- Flurothyl
- Furosemide
- Golexanolone
- Iomazenil (123I)
- IPTBO
- Isopregnanolone (sepranolone)
- L-655,708
- Laudanosine
- Lindane
- MaxiPost
- Morphine
- Morphine-3-glucuronide
- MRK-016
- Naloxone
- Naltrexone
- Nicardipine
- Nonsteroidal antiandrogens(e.g.,apalutamide,bicalutamide,enzalutamide,flutamide,nilutamide)
- Oenanthotoxin
- Pentylenetetrazol (pentetrazol)
- Phenylsilatrane
- Picrotoxin(i.e.,picrotin,picrotoxininanddihydropicrotoxinin)
- Pregnenolone sulfate
- Propybicyphat
- PWZ-029
- Radequinil
- Ro 15-4513
- Ro 19-4603
- RO4882224
- RO4938581
- Sarmazenil
- SCS
- Suritozole
- TB-21007
- TBOB
- TBPS
- TCS-1105
- Terbequinil
- TETS
- Thujone
- U-93631
- Zinc
- ZK-93426
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| GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor | |
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| Metabotropic | | GABABTooltip γ-Aminobutyric acid B receptor | |
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