Beclamide

Beclamide
Clinical data
Routes of; administration	By mouth
ATC code	N03AX30(WHO);
Legal status
Legal status	BR:Class C1(Other controlled substances);
Identifiers
	IUPAC name N-Benzyl-3-chloropropanamide;
CAS Number	501-68-8;
PubChemCID	10391;
ChemSpider	9962;
UNII	F5N0ALI65V;
KEGG	D07300;
ChEMBL	ChEMBL64195;
CompTox Dashboard(EPA)	DTXSID5057755;
ECHA InfoCard	100.007.207
Chemical and physical data
Formula	C10H12ClNO
Molar mass	197.66g·mol−1
3D model (JSmol)	Interactive image;
Melting point	94 °C (201 °F)
	SMILES ClCCC(=O)NCc1ccccc1;
	InChI InChI=1S/C10H12ClNO/c11-7-6-10(13)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13); Key:JPYQFYIEOUVJDU-UHFFFAOYSA-N;
	(verify)

Beclamide(marketed asChloracon,Hibicon,Posedrine,Nydrane,Seclar,and other names) is adrugthat possesses anticonvulsant activity.^[2]It is no longer used.

Uses

It has been used as asedativeand as ananticonvulsant.

It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonicseizures.It was not effective forabsence seizures.

Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment ofschizophrenia.^[3]

Side effects

Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash andleukopenia.It is counter-indicated in breast feeding as it is passed in the milk.

References

^Anvisa(2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União(published 2023-04-04).Archivedfrom the original on 2023-08-03.Retrieved2023-08-16.
^Ahmadi M, Nicholls PJ, Smith HJ, Spencer PS, Preet-Ryatt MS, Spragg BP (October 1995). "Metabolism of beclamide after a single oral dose in man: quantitative studies".The Journal of Pharmacy and Pharmacology.47(10): 876–8.doi:10.1111/j.2042-7158.1995.tb05757.x.PMID 8583359.S2CID 19556266.
^Raptis C, Garcia-Borreguero D, Weber MM, Dose M, Bremer D, Emrich HM (February 1990). "Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide".Acta Psychiatrica Scandinavica.81(2): 162–7.doi:10.1111/j.1600-0447.1990.tb06472.x.PMID 2183543.S2CID 26772370.

The Medical Treatment of Epilepsyby Stanley R Resor. Published by Marcel Dekker (1991).ISBN 0-8247-8549-5.

Thisanticonvulsant-related article is astub.You can help Wikipedia byexpanding it.

[1] Anvisa(2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União(published 2023-04-04).Archivedfrom the original on 2023-08-03.Retrieved2023-08-16.

[pmid8583359-2] Ahmadi M, Nicholls PJ, Smith HJ, Spencer PS, Preet-Ryatt MS, Spragg BP (October 1995). "Metabolism of beclamide after a single oral dose in man: quantitative studies".The Journal of Pharmacy and Pharmacology.47(10): 876–8.doi:10.1111/j.2042-7158.1995.tb05757.x.PMID 8583359.S2CID 19556266.

[pmid2183543-3] Raptis C, Garcia-Borreguero D, Weber MM, Dose M, Bremer D, Emrich HM (February 1990). "Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide".Acta Psychiatrica Scandinavica.81(2): 162–7.doi:10.1111/j.1600-0447.1990.tb06472.x.PMID 2183543.S2CID 26772370.

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