Beclamide
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Routes of administration | By mouth |
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ECHA InfoCard | 100.007.207 |
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Formula | C10H12ClNO |
Molar mass | 197.66g·mol−1 |
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Melting point | 94 °C (201 °F) |
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Beclamide(marketed asChloracon,Hibicon,Posedrine,Nydrane,Seclar,and other names) is adrugthat possesses anticonvulsant activity.[2]It is no longer used.
Uses
[edit]It has been used as asedativeand as ananticonvulsant.
It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalised tonic-clonicseizures.It was not effective forabsence seizures.
Interest in the drug resumed in the 1990s for its psychiatric properties as an adjunct in the treatment ofschizophrenia.[3]
Side effects
[edit]Side effects are uncommon but include stomach pain, nervousness, giddiness, skin rash andleukopenia.It is counter-indicated in breast feeding as it is passed in the milk.
References
[edit]- ^Anvisa(2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União(published 2023-04-04).Archivedfrom the original on 2023-08-03.Retrieved2023-08-16.
- ^Ahmadi M, Nicholls PJ, Smith HJ, Spencer PS, Preet-Ryatt MS, Spragg BP (October 1995). "Metabolism of beclamide after a single oral dose in man: quantitative studies".The Journal of Pharmacy and Pharmacology.47(10): 876–8.doi:10.1111/j.2042-7158.1995.tb05757.x.PMID8583359.S2CID19556266.
- ^Raptis C, Garcia-Borreguero D, Weber MM, Dose M, Bremer D, Emrich HM (February 1990). "Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide".Acta Psychiatrica Scandinavica.81(2): 162–7.doi:10.1111/j.1600-0447.1990.tb06472.x.PMID2183543.S2CID26772370.
- The Medical Treatment of Epilepsyby Stanley R Resor. Published by Marcel Dekker (1991).ISBN0-8247-8549-5.