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C-8813

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C-8813
Identifiers
  • trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC20H26BrNOS
Molar mass408.40g·mol−1
3D model (JSmol)
  • BrC1=CC=C([C@@]2(CC[C@](CC2)(CCC3=CC=CS3)O)N(C)C)C=C1
  • InChI=1S/C20H26BrNOS/c1-22(2)20(16-5-7-17(21)8-6-16)13-11-19(23,12-14-20)10-9-18-4-3-15-24-18/h3-8,15,23H,9-14H2,1-2H3/t19-,20-☒N
  • Key:XRDNIYBVNZLPJE-MXVIHJGJSA-N☒N
☒NcheckY(what is this?)(verify)

C-8813(thiobromadol) is a potentμ-opioid receptoragonistwith a distinctive chemical structure which is not closely related to other established families of opioid drugs. Thetrans-isomer was found to be around 591 times more potent thanmorphinein animal studies.[1]The same study assigned a potency of 504 times that of morphine to the related compoundBDPC.

C-8813 is claimed to be similarly potent at theδ-opioid receptor,which antagonizes the μ-induced depression of breathing, presumably making the drug safer.[1]

C-8813 has never been approved for use in humans.[citation needed]

See also

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References

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  1. ^abLiu ZH, Jin WQ, Dai QY, Chen XJ, Zhang HP, Chi ZQ (May 2003). "Opioid activity of C8813, a novel and potent opioid analgesic".Life Sciences.73(2): 233–41.doi:10.1016/S0024-3205(03)00263-7.PMID12738037.