C-8813

C-8813
Identifiers
	IUPAC name trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol;
CAS Number	616898-54-5;
PubChemCID	11058633;
ChemSpider	48059007;
UNII	D343S4VX5G;
Chemical and physical data
Formula	C20H26BrNOS
Molar mass	408.40g·mol−1
3D model (JSmol)	Interactive image;
	SMILES BrC1=CC=C([C@@]2(CC[C@](CC2)(CCC3=CC=CS3)O)N(C)C)C=C1;
	InChI InChI=1S/C20H26BrNOS/c1-22(2)20(16-5-7-17(21)8-6-16)13-11-19(23,12-14-20)10-9-18-4-3-15-24-18/h3-8,15,23H,9-14H2,1-2H3/t19-,20-; Key:XRDNIYBVNZLPJE-MXVIHJGJSA-N;
	(what is this?)(verify)

C-8813(thiobromadol) is a potentμ-opioid receptor agonistwith a distinctive chemical structure which is not closely related to other established families of opioid drugs. Thetrans-isomer was found to be around 591 times more potent thanmorphinein animal studies.^[1]The same study assigned a potency of 504 times that of morphine to the related compoundBDPC.

C-8813 is claimed to be similarly potent at theδ-opioid receptor,which antagonizes the μ-induced depression of breathing, presumably making the drug safer.^[1]

C-8813 has never been approved for use in humans.^{[citation needed]}

References

^^a ^bLiu ZH, Jin WQ, Dai QY, Chen XJ, Zhang HP, Chi ZQ (May 2003). "Opioid activity of C8813, a novel and potent opioid analgesic".Life Sciences.73(2): 233–41.doi:10.1016/S0024-3205(03)00263-7.PMID 12738037.

Thisanalgesic-related article is astub.You can help Wikipedia byexpanding it.

[Liu-1] Liu ZH, Jin WQ, Dai QY, Chen XJ, Zhang HP, Chi ZQ (May 2003). "Opioid activity of C8813, a novel and potent opioid analgesic".Life Sciences.73(2): 233–41.doi:10.1016/S0024-3205(03)00263-7.PMID 12738037.

[1]

See also

References