CACNG4
Appearance
Voltage-dependent calcium channel gamma-4 subunitis aproteinthat in humans is encoded by theCACNG4gene.[5][6]
L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.[6]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000075461–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000020723–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Burgess DL, Davis CF, Gefrides LA, Noebels JL (Jan 2000)."Identification of Three Novel Ca2+ Channel γ Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication".Genome Res.9(12): 1204–13.doi:10.1101/gr.9.12.1204.PMC311002.PMID10613843.
- ^ab"Entrez Gene: CACNG4 calcium channel, voltage-dependent, gamma subunit 4".
Further reading
[edit]- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Moss FJ, Dolphin AC, Clare JJ (2004)."Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes".BMC Neuroscience.4:23.doi:10.1186/1471-2202-4-23.PMC270087.PMID14505496.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Chu PJ, Robertson HM, Best PM (2002). "Calcium channel gamma subunits provide insights into the evolution of this gene family".Gene.280(1–2): 37–48.doi:10.1016/S0378-1119(01)00738-7.PMID11738816.
- Burgess DL, Gefrides LA, Foreman PJ, Noebels JL (2001). "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family".Genomics.71(3): 339–50.doi:10.1006/geno.2000.6440.PMID11170751.
- Powers PA, Liu S, Hogan K, Gregg RG (1993)."Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location".J. Biol. Chem.268(13): 9275–9.doi:10.1016/S0021-9258(18)98346-8.PMID8387489.
External links
[edit]- CACNG4+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- HumanCACNG4genome location andCACNG4gene details page in theUCSC Genome Browser.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.