CCDC181
This articleneeds additional citations forverification.(May 2018) |
CCDC181 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CCDC181,C1orf114, coiled-coil domain containing 181 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI:1922145;HomoloGene:10912;GeneCards:CCDC181;OMA:CCDC181 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Coiled-coil domain-containing protein 181(CCDC181) is aproteinthat in human is encoded by C1orf114,[5]which is located at theChromosome 1at 1q24.2.[5]The accession is Q5T1D7.[5]Researches have recently revealed that CCDC 181 is amicrotubule-binding protein that interacts withmurineHook1inhaploidmale germ cells and localizes to the sperm tail and motile cilia.[6]The disruption of Hook1 may lead to inappropriate function ofspermatogenesis.The dysfunction may be related to the abnormal head shape ofspermor distinctive structural changes inflagellain sperm, which can result inmale infertility.An increased rate of my gene has found in the haploid phase of male cell duringmeiosis,thus it is believed to relate to sperm cell and aid in spermatogenesis.
Expression
[edit]![](https://upload.wikimedia.org/wikipedia/commons/thumb/1/19/Expression_of_CCDC_181_in_different_condition.png/220px-Expression_of_CCDC_181_in_different_condition.png)
It is discovered that a significant high expression of CCDC 181 found on humantestis,which is a malereproductivegland.This is related to the study of its encoded protein-CCDC181, which relates to human infertility when in low expression. Also, high expression of protein is found in theolfactory areaandcortical subplate.Researchers have studied the expression of CCDC 181 under different conditions. One of the outstanding findings is that under the coexistence ofRho GTP dissociation inhibitor,the expression of CCDC 181 is depressed. Rho GTP dissociation inhibitor has a phenomenal effect onbladder cancercells, so studies have suggested that CCDC 181 might also be related to bladder cancer.
Homology
[edit]Orthologs have been found mainly ineukaryotes,including mammals, birds, reptiles, amphibians and fishes, with the highest identity on the mammalian species.
Genus
species |
Common
name |
Divergence
from humans (MYA) |
NCBI
mRNA accession |
Sequence
identity |
Sequence similarity | Length
(aa) |
Homo sapiens | Humans | -- | NM_001300968 | -- | -- | 508 |
Odobenus rosmarusdivergens | Walrus | 96 | XP_012420860 | 86% | 93% | 507 |
Physeter catodon | Sperm whale | 96 | XP_007102112 | 84% | 91% | 509 |
Balaenoptera acutorostratascammoni | Minke whale | 96 | XP_007172548 | 84% | 90% | 509 |
Ictidomys tridecemlineatus | Thirteen-lined ground squirrel | 90 | XP_021578354 | 81% | 90% | 507 |
Octodon degus | Degu | 90 | XP_023564408 | 80% | 89% | 537 |
Rousettus aegyptiacus | Egyptian fruit bat | 96 | XP_016004092 | 78% | 88% | 505 |
Pteropus vampyrus | Large flying fox | 96 | XP_023393329 | 78% | 89% | 522 |
Condylura cristata | star-nosed mole | 96 | XP_004688522 | 78% | 87% | 508 |
Mustela putoriusfuro | Ferret | 96 | XP_004756715 | 69% | 78% | 459 |
Nestor notabilis | Kea | 312 | XP_010014066 | 56% | 72% | 498 |
Pelodiscus sinensis | Chinese softshell turtle | 312 | XP_006112275 | 55% | 73% | 512 |
Sorex araneus | shrew | 96 | XP_012789334 | 55% | 71% | 502 |
Chelonia mydas | Green sea turtle | 312 | XP_007061692 | 54% | 72% | 517 |
Xenopus tropicalis | western clawed frog | 352 | XP_012813116 | 42% | 61% | 471 |
Lonchura striata domestica | society finch | 312 | XP_021404557 | 40% | 61% | 488 |
Nanorana parkeri | High Himalaya frog | 352 | XP_018423291 | 36% | 56% | 334 |
Scleropages formosus | Asian arowana | 435 | XP_018603557 | 35% | 55% | 389 |
Hippocampus comes | Tiger tail seahorse | 435 | XP_019735712 | 29% | 44% | 439 |
- ^abcGRCh38: Ensembl release 89: ENSG00000117477–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000026578–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^abc"Homo sapiens coiled-coil domain containing 181 (CCDC181), transcript v - Nucleotide - NCBI".ncbi.nlm.nih.gov.Retrieved2018-05-01.
- ^Schwarz T, Prieler B, Schmid JA, Grzmil P, Neesen J (May 2017)."Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia".European Journal of Cell Biology.96(3): 276–288.doi:10.1016/j.ejcb.2017.02.003.PMC5496667.PMID28283191.