VE-cadherin
(Redirected fromCDH5)
Cadherin-5,orVE-cadherin(vascular endothelial cadherin), also known asCD144(Cluster ofDifferentiation144), is a type ofcadherin.It is encoded by the humangeneCDH5.[5]
Function
[edit]VE-cadherin is a classical cadherin from the cadherin superfamily and the gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell–cell adhesionglycoproteincomposed of five extracellular cadherin repeats, a transmembrane region and a highly conservedcytoplasmic tail.Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.[6]
Integrity of intercellular junctions is a major determinant of permeability of theendothelium,and the VE-cadherin-basedadherens junctionis thought to be particularly important. VE-cadherin is known to be required for maintaining a restrictive endothelial barrier – early studies using blocking antibodies to VE-cadherin increased monolayer permeability in cultured cells[7]and resulted in interstitial edema and hemorrhage in vivo.[8]A recent study has shown thatTNFAIP3(A20, a dual-ubiquitinediting enzyme) is essential for stability and expression of VE-cadherin.Deubiquitinasefunction of A20 was shown to remove ubiquitin chains from VE-cadherin, thereby prevented loss of VE-cadherin expression at the endothelial adherens junctions.[9]
VE-cadherin is indispensable for proper vascular development – there have been two transgenic mouse models of VE-cadherin deficiency, both embryonic lethal due to vascular defects.[10][11]Further studies using one of these models revealed that althoughvasculogenesisoccurred, nascent vessels collapsed or disassembled in the absence of VE-cadherin.[12]Therefore, it was concluded that VE-cadherin serves the purpose of maintaining newly formed vessels.
Interactions
[edit]VE-cadherin has been shown tointeractwith:
- Beta-catenin[13][14]
- Plakoglobin[13][14]
- PTPRB[15]
- Catenin (cadherin-associated protein), Alpha 1[13][14]
- CTNND1[16][17]
- PTPmu (PTPRM)[18]
- PTPrho (PTPRT)[19]
As a biomarker
[edit]VE-cadherin may serve as abiomarkerforradiation exposure.[20]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000179776–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000031871–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Suzuki S, Sano K, Tanihara H (April 1991)."Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue".Cell Regul.2(4): 261–70.doi:10.1091/mbc.2.4.261.PMC361775.PMID2059658.
- ^"Entrez Gene: CDH5 cadherin 5, type 2, VE-cadherin (vascular epithelium)".
- ^Corada M, Liao F, Lindgren M, Lampugnani MG, Breviario F, Frank R, Muller WA, Hicklin DJ, Bohlen P, Dejana E (March 2001)."Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability".Blood.97(6): 1679–84.doi:10.1182/blood.V97.6.1679.PMID11238107.
- ^Corada M, Zanetta L, Orsenigo F, Breviario F, Lampugnani MG, Bernasconi S, Liao F, Hicklin DJ, Bohlen P, Dejana E (August 2002)."A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability".Blood.100(3): 905–11.doi:10.1182/blood.V100.3.905.PMID12130501.
- ^Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018)."Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury".Cell Death Discovery.4(60): 60.doi:10.1038/s41420-018-0056-3.PMC5955943.PMID29796309.
- ^Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oosthuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E (July 1999)."Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis".Cell.98(2): 147–57.doi:10.1016/S0092-8674(00)81010-7.PMID10428027.S2CID2668221.
- ^Gory-Fauré S, Prandini MH, Pointu H, Roullot V, Pignot-Paintrand I, Vernet M, Huber P (May 1999)."Role of vascular endothelial-cadherin in vascular morphogenesis".Development.126(10): 2093–102.doi:10.1242/dev.126.10.2093.PMID10207135.
- ^Crosby CV, Fleming PA, Argraves WS, Corada M, Zanetta L, Dejana E, Drake CJ (April 2005)."VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly".Blood.105(7): 2771–6.doi:10.1182/blood-2004-06-2244.PMID15604224.
- ^abcLewalle JM, Bajou K, Desreux J, Mareel M, Dejana E, Noël A, Foidart JM (Dec 1997). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro".Exp. Cell Res.237(2): 347–56.doi:10.1006/excr.1997.3799.hdl:2268/61990.PMID9434630.
- ^abcShasby DM, Ries DR, Shasby SS, Winter MC (Jun 2002)."Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin".Am. J. Physiol. Lung Cell Mol. Physiol.282(6): L1330–8.doi:10.1152/ajplung.00329.2001.PMID12003790.
- ^Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G, Golding M, Shima DT, Deutsch U, Vestweber D (Sep 2002)."VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts".EMBO J.21(18): 4885–95.doi:10.1093/emboj/cdf497.PMC126293.PMID12234928.
- ^Ferber A, Yaen C, Sarmiento E, Martinez J (Mar 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation".Exp. Cell Res.274(1): 35–44.doi:10.1006/excr.2001.5436.PMID11855855.
- ^Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (Sep 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells".J. Cell Sci.110(17): 2065–77.doi:10.1242/jcs.110.17.2065.PMID9378757.
- ^Sui XF, Kiser TD, Hyun SW, Angelini DJ, Del Vecchio RL, Young BA, Hasday JD, Romer LH, Passaniti A, Tonks NK, Goldblum SE (2005)."Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia".Am J Pathol.166(4): 1247–58.doi:10.1016/s0002-9440(10)62343-7.PMC1602370.PMID15793303.
- ^Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (2006). "Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)".Brain Res.1116(1): 50–7.doi:10.1016/j.brainres.2006.07.122.PMID16973135.S2CID23343123.
- ^Hérodin F, Voir D, Vilgrain I, Courçon M, Drouet M, Boittin FX (June 2016). "Soluble Vascular Endothelial Cadherin as a New Biomarker of Irradiation in Highly Irradiated Baboons with Bone Marrow Protection".Health Physics.110(6): 598–605.doi:10.1097/HP.0000000000000481.PMID27115227.S2CID3314728.
Further reading
[edit]- Lampugnani MG, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G, Ruco LP, Dejana E (1992)."A novel endothelial-specific membrane protein is a marker of cell-cell contacts".J. Cell Biol.118(6): 1511–22.doi:10.1083/jcb.118.6.1511.PMC2289607.PMID1522121.
- Suzuki S, Sano K, Tanihara H (1991)."Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue".Cell Regul.2(4): 261–70.doi:10.1091/mbc.2.4.261.PMC361775.PMID2059658.
- Breviario F, Caveda L, Corada M, Martin-Padura I, Navarro P, Golay J, Introna M, Gulino D, Lampugnani MG, Dejana E (1995). "Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin".Arterioscler. Thromb. Vasc. Biol.15(8): 1229–39.doi:10.1161/01.ATV.15.8.1229.PMID7627717.
- Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion".Microcirculation.4(2): 267–77.doi:10.3109/10739689709146790.PMID9219219.S2CID21501093.
- Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells".J. Cell Sci.110(17): 2065–77.doi:10.1242/jcs.110.17.2065.PMID9378757.
- Lewalle JM, Bajou K, Desreux J, Mareel M, Dejana E, Noël A, Foidart JM (1998). "Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro".Exp. Cell Res.237(2): 347–56.doi:10.1006/excr.1997.3799.hdl:2268/61990.PMID9434630.
- Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity".Genomics.49(3): 467–71.doi:10.1006/geno.1998.5281.PMID9615235.
- Kowalczyk AP, Navarro P, Dejana E, Bornslaeger EA, Green KJ, Kopp DS, Borgwardt JE (1998). "VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions".J. Cell Sci.111(20): 3045–57.doi:10.1242/jcs.111.20.3045.PMID9739078.
- Kawashima M, Kitagawa M (1999). "An immunohistochemical study of cadherin 5 (VE-cadherin) in vascular endothelial cells in placentas with gestosis".J. Obstet. Gynaecol. Res.24(6): 375–84.doi:10.1111/j.1447-0756.1998.tb00112.x.PMID10063232.S2CID12405995.
- Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oosthuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E (1999)."Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis".Cell.98(2): 147–57.doi:10.1016/S0092-8674(00)81010-7.PMID10428027.S2CID2668221.
- Ukropec JA, Hollinger MK, Salva SM, Woolkalis MJ (2000)."SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin".J. Biol. Chem.275(8): 5983–6.doi:10.1074/jbc.275.8.5983.PMID10681592.
- Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001)."Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins".Biochem. J.349(Pt 1): 159–67.doi:10.1042/0264-6021:3490159.PMC1221133.PMID10861224.
- Shaw SK, Bamba PS, Perkins BN, Luscinskas FW (2001)."Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium".J. Immunol.167(4): 2323–30.doi:10.4049/jimmunol.167.4.2323.PMID11490021.
- van Buul JD, Voermans C, van den Berg V, Anthony EC, Mul FP, van Wetering S, van der Schoot CE, Hordijk PL (2002)."Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin".J. Immunol.168(2): 588–96.doi:10.4049/jimmunol.168.2.588.PMID11777950.
- Ferber A, Yaen C, Sarmiento E, Martinez J (2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation".Exp. Cell Res.274(1): 35–44.doi:10.1006/excr.2001.5436.PMID11855855.
- Gorlatov S, Medved L (2002). "Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains".Biochemistry.41(12): 4107–16.doi:10.1021/bi0160314.PMID11900554.
- Di Simone N, Castellani R, Caliandro D, Caruso A (2003)."Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules".Fertil. Steril.77(4): 805–11.doi:10.1016/S0015-0282(01)03258-7.PMID11937138.
- Zanetti A, Lampugnani MG, Balconi G, Breviario F, Corada M, Lanfrancone L, Dejana E (2002)."Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling".Arterioscler. Thromb. Vasc. Biol.22(4): 617–22.doi:10.1161/01.ATV.0000012268.84961.AD.PMID11950700.
- Lampugnani MG, Zanetti A, Breviario F, Balconi G, Orsenigo F, Corada M, Spagnuolo R, Betson M, Braga V, Dejana E (2002)."VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam".Mol. Biol. Cell.13(4): 1175–89.doi:10.1091/mbc.01-07-0368.PMC102260.PMID11950930.
- Vincent PA, Xiao K, Buckley KM, Kowalczyk AP (2004). "VE-cadherin: adhesion at arm's length".Am J Physiol Cell Physiol.286(5): C987–97.doi:10.1152/ajpcell.00522.2003.PMID15075197.
External links
[edit]- VE-cadherin+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- CDH5human gene location in theUCSC Genome Browser.
- CDH5human gene details in theUCSC Genome Browser.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.