CENPL

CENPL
Identifiers
Aliases	CENPL,C1orf155, CENP-L, dJ383J4.3, centromere protein L
External IDs	OMIM:611503;MGI:1917704;HomoloGene:19618;GeneCards:CENPL;OMA:CENPL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,824,720bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,914,294bp
RNA expressionpattern
	Top expressed in
	oocyte; ; ventricular zone; ; secondary oocyte; ; gonad; ; ganglionic eminence; ; testicle; ; endothelial cell; ; bone marrow; ; stromal cell of endometrium; ; bone marrow cells;
	Top expressed in
	hand; ; medial ganglionic eminence; ; genital tubercle; ; thymus; ; ventricular zone; ; granulocyte; ; tail of embryo; ; epiblast; ; embryo; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	chromosome; cytosol; chromosome, centromeric region; nucleus; nucleoplasm;
Biological process	CENP-A containing chromatin assembly;
	Sources:Amigo/QuickGO
Orthologs
	91687
	70454
	ENSG00000120334
	ENSMUSG00000026708
	Q8N0S6
	Q3U3S3
	NM_033319; NM_001127181; NM_001171182
	NM_001159930; NM_027429
	NP_001120653; NP_001164653; NP_201576
	NP_001153402
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein Lis aproteinthat in humans is encoded by theCENPLgene.^[5]^[6]^[7]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000120334–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000026708–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres".Nat Cell Biol.8(5): 446–57.doi:10.1038/ncb1396.PMID 16622420.S2CID 26974412.
^Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex".Nat Cell Biol.8(5): 458–69.doi:10.1038/ncb1397.PMID 16622419.S2CID 205286556.
^"Entrez Gene: CENPL centromere protein L".

External links

HumanCENPLgenome location andCENPLgene details page in theUCSC Genome Browser.

Izuta H, Ikeno M, Suzuki N, et al. (2006)."Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells".Genes Cells.11(6): 673–84.doi:10.1111/j.1365-2443.2006.00969.x.PMID 16716197.
Gregory SG, Barlow KF, McLay KE, et al. (2006)."The DNA sequence and biological annotation of human chromosome 1".Nature.441(7091): 315–21.Bibcode:2006Natur.441..315G.doi:10.1038/nature04727.PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.
Obuse C, Yang H, Nozaki N, et al. (2004)."Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase".Genes Cells.9(2): 105–20.doi:10.1111/j.1365-2443.2004.00705.x.PMID 15009096.S2CID 21813024.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120334–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026708–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16622420-5] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres".Nat Cell Biol.8(5): 446–57.doi:10.1038/ncb1396.PMID 16622420.S2CID 26974412.

[pmid16622419-6] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex".Nat Cell Biol.8(5): 458–69.doi:10.1038/ncb1397.PMID 16622419.S2CID 205286556.

[entrez-7] "Entrez Gene: CENPL centromere protein L".

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References

External links

Further reading