CXCL15

Cxcl15
Identifiers
Aliases	chemokine (C-X-C motif) ligand 15Il8Scyb15lungkineweche
External IDs	GeneCards:[1];OMA:- orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	90,950,926bp
RNA expressionpattern
	Top expressed in
	left lung lobe; ; right lung lobe; ; trachea; ; cervix; ; sexually immature organism; ; mammary gland; ; external carotid artery; ; lobe of prostate; ; genital tubercle; ; nucleus accumbens;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	chemokine activity; cytokine activity; CXCR3 chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; response to lipopolysaccharide; inflammatory response; regulation of cell population proliferation; immune response; neutrophil chemotaxis; positive regulation of leukocyte chemotaxis; defense response; T cell chemotaxis; regulation of signaling receptor activity; hemopoiesis; leukocyte chemotaxis; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide;
	Sources:Amigo/QuickGO
Orthologs
	20309
	n/a
	ENSMUSG00000029375
	n/a
	Q9WVL7
	n/a
	NM_011339
	n/a
	NP_035469
	n/a
	Wikidata
View/Edit Human

Chemokine (C-X-C motif) ligand 15(CXCL15) is a smallcytokinebelonging to the CXCchemokinefamily that has been described in the mouse. This chemokine is also known under the namelungkine.CXCL15 is an ELR+ CXC chemokine (it contains theamino acidsequence E-L-R immediately before its CXC motif) that recruitsneutrophilsduring inflammation of thelungs.It is highly abundant inepithelial cellsof the lung,^[2]and can also be found in othermucosal organssuch as theurogenitalandgastrointestinal tracts,and inendocrineorgans like theadrenal gland.^[3]Thegenefor CXCL15 is found on mousechromosome5.

References

^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999)."Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells".J Immunol.162(9): 5490–7.doi:10.4049/jimmunol.162.9.5490.PMID 10228029.
^Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007)."Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs".J Histochem Cytochem.55(5): 515–24.doi:10.1369/jhc.6A7121.2007.PMID 17242461.

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[1] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999)."Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells".J Immunol.162(9): 5490–7.doi:10.4049/jimmunol.162.9.5490.PMID 10228029.

[3] Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007)."Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs".J Histochem Cytochem.55(5): 515–24.doi:10.1369/jhc.6A7121.2007.PMID 17242461.

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