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Cardiovascular disease

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"Heart condition" redirects here. For other uses, seeHeart condition (disambiguation).
Cardiovascular disease
Micrographof aheartwithfibrosis(yellow) andamyloidosis(brown).Movat's stain.
SpecialtyCardiology
SymptomsChest pain,shortness of breath,fatigue,loss of consciousness
ComplicationsHeart failure, heart attack, stroke, aneurysm, peripheral artery disease, sudden cardiac arrest.[1]
Usual onsetOlder adults[2]
TypesCoronary artery diseases,stroke,heart failure,hypertensive heart disease,rheumatic heart disease,cardiomyopathy,[3][4]Arrhythmia
Risk factorsDiabetes,[3]high blood lipids,excess weight,Smoking,excessive drug use, and excessivealcoholintake
PreventionHealthy eating,exercise, avoiding tobacco smoke, limited alcohol intake,[3]Overall lifestyle changes
TreatmentTreatinghigh blood pressure,high blood lipids,diabetes[3]
MedicationAspirin,beta blockers,blood thinners
Deaths17.9 million / 32% (2015)[5]

Cardiovascular disease(CVD) is any disease involving theheartorblood vessels.[3]CVDs constitute a class of diseases that includes:coronary artery diseases(e.g.angina,heart attack),heart failure,hypertensive heart disease,rheumatic heart disease,cardiomyopathy,arrhythmia,congenital heart disease,valvular heart disease,carditis,aortic aneurysms,peripheral artery disease,thromboembolic disease,andvenous thrombosis.[3][4]

The underlying mechanisms vary depending on the disease.[3]It is estimated that dietary risk factors are associated with 53% of CVD deaths.[6]Coronary artery disease, stroke, and peripheral artery disease involveatherosclerosis.[3]This may be caused byhigh blood pressure,smoking,diabetes mellitus,lack ofexercise,obesity,high blood cholesterol,poor diet, excessivealcoholconsumption,[3]and poorsleep,[7][8]among other things. High blood pressure is estimated to account for approximately 13% of CVD deaths, while tobacco accounts for 9%, diabetes 6%, lack of exercise 6%, and obesity 5%.[3]Rheumatic heart disease may follow untreatedstrep throat.[3]

It is estimated that up to 90% of CVD may be preventable.[9][10]Prevention of CVD involves improving risk factors through:healthy eating,exercise, avoidance of tobacco smoke and limiting alcohol intake.[3]Treating risk factors, such as high blood pressure, blood lipids and diabetes is also beneficial.[3]Treating people who have strep throat withantibioticscan decrease the risk of rheumatic heart disease.[11]The use ofaspirinin people who are otherwise healthy is of unclear benefit.[12][13]

Cardiovascular diseases are theleading cause of deathworldwide except Africa.[3]Together CVD resulted in 17.9 million deaths (32.1%) in 2015, up from 12.3 million (25.8%) in 1990.[5][4]Deaths, at a given age,from CVD are more common and have been increasing in much of thedeveloping world,while rates have declined in most of thedeveloped worldsince the 1970s.[14][15]Coronary artery disease and stroke account for 80% of CVD deaths in males and 75% of CVD deaths in females.[3]Most cardiovascular disease affects older adults. In the United States 11% of people between 20 and 40 have CVD, while 37% between 40 and 60, 71% of people between 60 and 80, and 85% of people over 80 have CVD.[2]The average age of death from coronary artery disease in the developed world is around 80, while it is around 68 in the developing world.[14]CVD is typically diagnosed seven to ten years earlier in men than in women.[3]: 48 

Types

Disability-adjusted life yearfor inflammatory heart diseases per 100,000 inhabitants in 2004[16]
No data
Less than 70
70–140
140–210
210–280
280–350
350–420
420–490
490–560
560–630
630–700
700–770
More than 770

There are many cardiovascular diseases involving the blood vessels. They are known asvascular diseases.[17]

There are also many cardiovascular diseases that involve the heart.

Risk factors

There are many risk factors for heart diseases: age, sex, tobacco use, physical inactivity,non-alcoholic fatty liver disease,excessivealcoholconsumption, unhealthy diet, obesity, genetic predisposition and family history of cardiovascular disease, raised blood pressure (hypertension), raised blood sugar (diabetes mellitus), raised blood cholesterol (hyperlipidemia), undiagnosedceliac disease,psychosocial factors, poverty and low educational status,air pollution,and poorsleep.[3][18][19][20][21][22]While the individual contribution of each risk factor varies between different communities or ethnic groups the overall contribution of these risk factors is very consistent.[23]Some of these risk factors, such as age, sex or family history/genetic predisposition, are immutable; however, many important cardiovascular risk factors are modifiable by lifestyle change, social change, drug treatment (for example prevention of hypertension, hyperlipidemia, and diabetes).[24]People with obesity are at increased risk ofatherosclerosisof thecoronary arteries.[25]

Genetics

Cardiovascular disease in a person's parents increases their risk by ~3 fold,[26]and genetics is an important risk factor for cardiovascular diseases. Genetic cardiovascular disease can occur either as a consequence of single variant (Mendelian) or polygenic influences.[27]There are more than 40 inherited cardiovascular disease that can be traced to a single disease-causing DNA variant, although these conditions are rare.[27]Most common cardiovascular diseases are non-Mendelian and are thought to be due to hundreds or thousands of genetic variants (known as single nucleotide polymorphisms), each associated with a small effect.[28][29]

Age

Calcified heart of an older woman with cardi Omega ly

Age is the most important risk factor in developing cardiovascular or heart diseases, with approximately a tripling of risk with each decade of life.[30]Coronary fatty streaks can begin to form in adolescence.[31]It is estimated that 82 percent of people who die of coronary heart disease are 65 and older.[32]Simultaneously, the risk of stroke doubles every decade after age 55.[33]

Multiple explanations are proposed to explain why age increases the risk of cardiovascular/heart diseases. One of them relates to serum cholesterol level.[34]In most populations, the serum total cholesterol level increases as age increases. In men, this increase levels off around age 45 to 50 years. In women, the increase continues sharply until age 60 to 65 years.[34]

Aging is also associated with changes in the mechanical and structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance and may subsequently lead to coronary artery disease.[35]

Sex

See also:Cardiovascular disease in women

Men are at greater risk of heart disease than pre-menopausal women.[30][36]Once pastmenopause,it has been argued that a woman's risk is similar to a man's[36]although more recent data from the WHO and UN disputes this.[30]If a female has diabetes, she is more likely to develop heart disease than a male with diabetes.[37]Women who have high blood pressure and had complications in their pregnancy have three times the risk of developing cardiovascular disease compared to women with normal blood pressure who had no complications in pregnancy.[38][39]

Coronary heart diseases are 2 to 5 times more common among middle-aged men than women.[34]In a study done by theWorld Health Organization,sex contributes to approximately 40% of the variation in sex ratios of coronary heart disease mortality.[40]Another study reports similar results finding that sex differences explains nearly half the risk associated with cardiovascular diseases[34]One of the proposed explanations for sex differences in cardiovascular diseases is hormonal difference.[34]Among women, estrogen is the predominant sex hormone.Estrogenmay have protective effects on glucose metabolism and hemostatic system, and may have direct effect in improvingendothelialcell function.[34]The production of estrogen decreases after menopause, and this may change the female lipid metabolism toward a more atherogenic form by decreasing theHDLcholesterol level while increasing LDL and total cholesterol levels.[34]

Among men and women, there are differences in body weight, height, body fat distribution, heart rate, stroke volume, and arterial compliance.[35]In the very elderly, age-related large artery pulsatility and stiffness are more pronounced among women than men.[35]This may be caused by the women's smaller body size and arterial dimensions which are independent of menopause.[35]

Tobacco

Cigarettes are the major form of smoked tobacco.[3]Risks to health from tobacco use result not only from direct consumption of tobacco, but also from exposure to second-hand smoke.[3]Approximately 10% of cardiovascular disease is attributed to smoking;[3]however, people who quit smoking by age 30 have almost as low a risk of death as never smokers.[41]

Physical inactivity

Further information:Sedentary lifestyle

Insufficient physical activity (defined as less than 5 x 30 minutes of moderate activity per week, or less than 3 x 20 minutes of vigorous activity per week) is currently the fourth leading risk factor for mortality worldwide.[3]In 2008, 31.3% of adults aged 15 or older (28.2% men and 34.4% women) were insufficiently physically active.[3] The risk of ischemic heart disease and diabetes mellitus is reduced by almost a third in adults who participate in 150 minutes of moderate physical activity each week (or equivalent).[42]In addition, physical activity assists weight loss and improves blood glucose control, blood pressure, lipid profile and insulin sensitivity. These effects may, at least in part, explain its cardiovascular benefits.[3]

Diet

Further information:Saturated fat § Cardiovascular disease,Salt and cardiovascular disease,andLipid hypothesis

High dietary intakes of saturated fat, trans-fats and salt, and low intake of fruits, vegetables and fish are linked to cardiovascular risk, although whether all these associations indicate causes is disputed. The World Health Organization attributes approximately 1.7 million deaths worldwide to low fruit and vegetable consumption.[3]Frequent consumption of high-energy foods, such as processed foods that are high in fats and sugars, promotes obesity and may increase cardiovascular risk.[3]The amount of dietary salt consumed may also be an important determinant of blood pressure levels and overall cardiovascular risk.[3]There is moderate quality evidence that reducing saturated fat intake for at least two years reduces the risk of cardiovascular disease.[43]Hightrans-fatintake has adverse effects on blood lipids and circulating inflammatory markers,[44]and elimination of trans-fat from diets has been widely advocated.[45][46]In 2018 the World Health Organization estimated that trans fats were the cause of more than half a million deaths per year.[46]There is evidence that higher consumption of sugar is associated with higher blood pressure and unfavorable blood lipids,[47]and sugar intake also increases the risk of diabetes mellitus.[48]High consumption of processed meatsis associated with an increased riskof cardiovascular disease, possibly in part due to increased dietary salt intake.[20]

Alcohol

Further information:Alcohol and cardiovascular disease

The relationship between alcohol consumption and cardiovascular disease is complex, and may depend on the amount of alcohol consumed.[49]There is a direct relationship between high levels of drinking alcohol and cardiovascular disease.[3]Drinking at low levels without episodes of heavy drinking may be associated with a reduced risk of cardiovascular disease,[50]but there is evidence that associations between moderate alcohol consumption and protection from stroke are non-causal.[51]At the population level, the health risks of drinking alcohol exceed any potential benefits.[3][52]

Celiac disease

Untreatedceliac diseasecan cause the development of many types of cardiovascular diseases, most of which improve or resolve with agluten-free dietand intestinal healing. However, delays in recognition and diagnosis of celiac disease can cause irreversible heart damage.[21]

Sleep

A lack of good sleep, in amount or quality, is documented as increasing cardiovascular risk in both adults and teens. Recommendations suggest that infants typically need 12 or more hours of sleep per day, adolescents at least eight or nine hours, and adults seven or eight. About one-third of adult Americans get less than the recommended seven hours of sleep per night, and in a study of teenagers, just 2.2 percent of those studied got enough sleep, many of whom did not get good quality sleep. Studies have shown that short sleepers getting less than seven hours sleep per night have a 10 percent to 30 percent higher risk of cardiovascular disease.[7][53]

Sleep disorders such assleep-disordered breathingandinsomnia,are also associated with a higher cardiometabolic risk.[54] An estimated 50 to 70 million Americans have insomnia,sleep apneaor other chronicsleep disorders.[citation needed]

In addition, sleep research displays differences in race and class. Short sleep and poor sleep tend to be more frequently reported in ethnic minorities than in whites. African-Americans report experiencing short durations of sleep five times more often than whites, possibly as a result of social and environmental factors. Black children and children living in disadvantaged neighborhoods have much higher rates of sleep apnea.[8]

Socioeconomic disadvantage

Cardiovascular disease has a greater impact on low- and middle-income countries compared to those with higher income.[55]Although data on the social patterns of cardiovascular disease in low- and middle-income countries is limited,[55]reports from high-income countries consistently demonstrate that low educational status or income are associated with a greater risk of cardiovascular disease.[56]Policies that have resulted in increased socio-economic inequalities have been associated with greater subsequent socio-economic differences in cardiovascular disease[55]implying a cause and effect relationship. Psychosocial factors, environmental exposures, health behaviours, and health-care access and quality contribute to socio-economic differentials in cardiovascular disease.[57]The Commission on Social Determinants of Health recommended that more equal distributions of power, wealth, education, housing, environmental factors, nutrition, and health care were needed to address inequalities in cardiovascular disease and non-communicable diseases.[58]

Air pollution

Particulate matterhas been studied for its short- and long-term exposureeffects on cardiovascular disease.Currently, airborne particles under 2.5 micrometers in diameter (PM2.5) are the major focus, in which gradients are used to determine CVD risk. Overall, long-term PM exposure increased rate of atherosclerosis and inflammation. In regards to short-term exposure (2 hours), every 25 μg/m3of PM2.5resulted in a 48% increase of CVD mortality risk.[59]In addition, after only 5 days of exposure, a rise in systolic (2.8 mmHg) and diastolic (2.7 mmHg) blood pressure occurred for every 10.5 μg/m3of PM2.5.[59]Other research has implicated PM2.5in irregular heart rhythm, reduced heart rate variability (decreased vagal tone), and most notably heart failure.[59][60]PM2.5is also linked tocarotid arterythickening and increased risk of acute myocardial infarction.[59][60]

Cardiovascular risk assessment

Existing cardiovascular disease or a previous cardiovascular event, such as a heart attack or stroke, is the strongest predictor of a future cardiovascular event.[61]Age, sex, smoking, blood pressure, blood lipids and diabetes are important predictors of future cardiovascular disease in people who are not known to have cardiovascular disease.[62]These measures, and sometimes others, may be combined into composite risk scores to estimate an individual's future risk of cardiovascular disease.[61]Numerous risk scores exist although their respective merits are debated.[63]Other diagnostic tests and biomarkers remain under evaluation but currently these lack clear-cut evidence to support their routine use. They include family history, coronary arterycalcificationscore,high sensitivity C-reactive protein(hs-CRP),ankle–brachial pressure index,lipoprotein subclasses and particle concentration, lipoprotein(a), apolipoproteins A-I and B,fibrinogen,white blood cell count,homocysteine,N-terminal pro B-type natriuretic peptide (NT-proBNP), and markers of kidney function.[64][65]High blood phosphorusis also linked to an increased risk.[66]

Depression and traumatic stress

There is evidence that mental health problems, in particular depression and traumatic stress, is linked to cardiovascular diseases. Whereas mental health problems are known to be associated with risk factors for cardiovascular diseases such as smoking, poor diet, and a sedentary lifestyle, these factors alone do not explain the increased risk of cardiovascular diseases seen in depression, stress, and anxiety.[67]Moreover,posttraumatic stress disorderis independently associated with increased risk for incident coronary heart disease, even after adjusting for depression and other covariates.[68]

Occupational exposure

Main article:Occupational cardiovascular disease

Little is known about the relationship between work and cardiovascular disease, but links have been established between certain toxins, extreme heat and cold, exposure to tobacco smoke, and mental health concerns such as stress and depression.[69]

Non-chemical risk factors

A 2015 SBU-report looking at non-chemical factors found an association for those:[70]

  • with mentally stressful work with a lack of control over their working situation — with an effort-reward imbalance[70]
  • who experience low social support at work; who experience injustice or experience insufficient opportunities for personal development; or those who experience job insecurity[70]
  • those who work night schedules; or have long working weeks[70]
  • those who are exposed to noise[70]

Specifically the risk ofstrokewas also increased by exposure to ionizing radiation.[70]Hypertension develops more often in those who experience job strain and who have shift-work.[70]Differences between women and men in risk are small, however men risk having and dying ofheart attacksor stroke twice as often as women during working life.[70]

Chemical risk factors

A 2017 SBU report found evidence that workplace exposure tosilica dust,engine exhaustorwelding fumesis associated with heart disease.[71]Associations also exist for exposure toarsenic,benzopyrenes,lead,dynamite,carbon disulphide,carbon monoxide,metalworking fluidsand occupational exposure totobacco smoke.[71]Working with theelectrolyticproduction of aluminium or the production of paper when the sulphate pulping process is used is associated with heart disease.[71]An association was also found between heart disease and exposure to compounds which are no longer permitted in certain work environments, such asphenoxy acidscontainingTCDD(dioxin) orasbestos.[71]

Workplace exposure to silica dust or asbestos is also associated withpulmonary heart disease.There is evidence that workplace exposure to lead, carbon disulphide, phenoxyacids containing TCDD, as well as working in an environment where aluminum is being electrolytically produced, is associated withstroke.[71]

Somatic mutations

As of 2017, evidence suggests that certainleukemia-associatedmutationsinblood cellsmay also lead to increased risk of cardiovascular disease. Several large-scale research projects looking at human genetic data have found a robust link between the presence of these mutations, a condition known asclonal hematopoiesis,and cardiovascular disease-related incidents and mortality.[72]

Radiation therapy

Radiation treatments (RT) for cancercan increase the risk of heart disease and death, as observed in breast cancer therapy.[73]Therapeutic radiation increases the risk of a subsequent heart attack or stroke by 1.5 to 4 times;[74]the increase depends on the dose strength, volume, and location. Use of concomitant chemotherapy, e.g. anthracyclines, is an aggravating risk factor.[75]The occurrence rate of RT induced cardiovascular disease is estimated between 10% and 30%.[75]

Side-effects from radiation therapy for cardiovascular diseases have been termedradiation-induced heart diseaseorradiation-induced cardiovascular disease.[76][77]Symptoms are dose-dependent and includecardiomyopathy,myocardial fibrosis,valvular heart disease,coronary artery disease,heart arrhythmiaandperipheral artery disease.Radiation-induced fibrosis, vascularcell damageandoxidative stresscan lead to these and other late side-effect symptoms.[76]

Pathophysiology

Density-Dependent Colour Scanning Electron Micrograph SEM (DDC-SEM) of cardiovascular calcification, showing in orange calcium phosphate spherical particles (denser material) and, in green, the extracellular matrix (less dense material)[78]

Population-based studies show that atherosclerosis, the major precursor of cardiovascular disease, begins in childhood. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study demonstrated that intimal lesions appear in all the aortas and more than half of the right coronary arteries of youths aged 7–9 years.[79]

Obesity anddiabetes mellitusare linked to cardiovascular disease,[80]as are a history of chronickidney diseaseandhypercholesterolaemia.[81]In fact, cardiovascular disease is the most life-threatening of the diabetic complications and diabetics are two- to four-fold more likely to die of cardiovascular-related causes than nondiabetics.[82][83][84]

Screening

ScreeningECGs(either at rest or with exercise) are not recommended in those without symptoms who are at low risk.[85]This includes those who are young without risk factors.[86]In those at higher risk the evidence for screening with ECGs is inconclusive.[87]Additionallyechocardiography,myocardial perfusion imaging,andcardiac stress testingis not recommended in those at low risk who do not have symptoms.[88]Somebiomarkersmay add to conventional cardiovascular risk factors in predicting the risk of future cardiovascular disease; however, the value of some biomarkers is questionable.[89][90]Ankle-brachial index(ABI),high-sensitivity C-reactive protein(hsCRP), andcoronary artery calcium,are also of unclear benefit in those without symptoms as of 2018.[91]

The NIH recommends lipid testing in children beginning at the age of 2 if there is a family history of heart disease or lipid problems.[92]It is hoped that early testing will improve lifestyle factors in those at risk such as diet and exercise.[93]

Screening and selection for primary prevention interventions has traditionally been done through absolute risk using a variety of scores (ex. Framingham or Reynolds risk scores).[94]This stratification has separated people who receive the lifestyle interventions (generally lower and intermediate risk) from the medication (higher risk). The number and variety of risk scores available for use has multiplied, but their efficacy according to a 2016 review was unclear due to lack of external validation or impact analysis.[95]Risk stratification models often lack sensitivity for population groups and do not account for the large number of negative events among the intermediate and low risk groups.[94]As a result, future preventative screening appears to shift toward applying prevention according to randomized trial results of each intervention rather than large-scale risk assessment.

Prevention

Up to 90% of cardiovascular disease may be preventable if established risk factors are avoided.[9][96]Currently practised measures to prevent cardiovascular disease include:

  • Maintaining ahealthy diet,such as theMediterranean diet,avegetarian,veganor anotherplant-based diet.[97][98][99][100]
  • Replacingsaturated fatwith healthier choices: Clinical trials show that replacing saturated fat with polyunsaturated vegetable oil reduced CVD by 30%. Prospective observational studies show that in many populations lower intake of saturated fat coupled with higher intake of polyunsaturated and monounsaturated fat is associated with lower rates of CVD.[101]
  • Decrease body fat if overweight or obese.[102]The effect of weight loss is often difficult to distinguish from dietary change, and evidence on weight reducing diets is limited.[103]In observational studies of people with severe obesity, weight loss following bariatric surgery is associated with a 46% reduction in cardiovascular risk.[104]
  • Limit alcohol consumption to the recommended daily limits.[97]People who moderately consume alcoholic drinks have a 25–30% lower risk of cardiovascular disease.[105][106]However, people who are genetically predisposed to consume less alcohol have lower rates of cardiovascular disease[107]suggesting that alcohol itself may not be protective. Excessive alcohol intake increases the risk of cardiovascular disease[108][106]and consumption of alcohol is associated with increased risk of a cardiovascular event in the day following consumption.[106]
  • Decrease non-HDL cholesterol.[109][110]Statintreatment reduces cardiovascular mortality by about 31%.[111]
  • Stopping smokingand avoidance of second-hand smoke.[97]Stopping smoking reduces risk by about 35%.[112]
  • At least 150 minutes (2 hours and 30 minutes) of moderate exercise per week.[113][114]
  • Lower blood pressure, if elevated. A 10 mmHg reduction in blood pressure reduces risk by about 20%.[115]Lowering blood pressure appears to be effective even at normal blood pressure ranges.[116][117][118]
  • Decreasepsychosocial stress.[119]This measure may be complicated by imprecise definitions of what constitute psychosocial interventions.[120]Mental stress–inducedmyocardial ischemiais associated with an increased risk of heart problems in those with previous heart disease.[121]Severe emotional and physical stress leads to a form of heart dysfunction known asTakotsubo syndromein some people.[122]Stress, however, plays a relatively minor role in hypertension.[123]Specific relaxation therapies are of unclear benefit.[124][125]
  • Not enough sleep also raises the risk of high blood pressure. Adults need about 7–9 hours of sleep. Sleep apnea is also a major risk as it causes breathing to stop briefly, which can put stress on the body which can raise the risk of heart disease.[126][127]

Most guidelines recommend combining preventive strategies. There is some evidence that interventions aiming to reduce more than one cardiovascular risk factor may have beneficial effects on blood pressure, body mass index and waist circumference; however, evidence was limited and the authors were unable to draw firm conclusions on the effects on cardiovascular events and mortality.[128]

There is additional evidence to suggest that providing people with a cardiovascular disease risk score may reduce risk factors by a small amount compared to usual care.[129]However, there was some uncertainty as to whether providing these scores had any effect on cardiovascular disease events. It is unclear whether or not dental care in those withperiodontitisaffects their risk of cardiovascular disease.[130]According to a 2021 WHO study, working 55+ hours a week raises the risk of stroke by 35% and the risk of dying from heart conditions by 17%, when compared to a 35-40 hours week.[131]

Diet

See also:Lipid hypothesis,Saturated fat and cardiovascular disease,andSalt and cardiovascular disease

A diet high in fruits and vegetables decreases the risk of cardiovascular disease anddeath.[132]

A 2021 review found thatplant-based dietscan provide a risk reduction for CVD if a healthy plant-based diet is consumed. Unhealthy plant-based diets do not provide benefits over diets including meat.[98]A similar meta-analysis and systematic review also looked into dietary patterns and found "that diets lower in animal foods and unhealthy plant foods, and higher in healthy plant foods are beneficial for CVD prevention".[99]A 2018 meta-analysis ofobservational studiesconcluded that "In most countries, a vegan diet is associated with a more favourable cardio-metabolic profile compared to an omnivorous diet."[100]

Evidence suggests that theMediterranean dietmay improve cardiovascular outcomes.[133]There is also evidence that a Mediterranean diet may be more effective than alow-fat dietin bringing about long-term changes to cardiovascular risk factors (e.g., lowercholesterol levelandblood pressure).[134]

TheDASH diet(high in nuts, fish, fruits and vegetables, and low in sweets, red meat and fat) has been shown to reduce blood pressure,[135]lower total and low density lipoprotein cholesterol[136]and improvemetabolic syndrome;[137]but the long-term benefits have been questioned.[138]A high-fiberdiet is associated with lower risks of cardiovascular disease.[139]

Worldwide, dietary guidelines recommend a reduction insaturated fat,[140]and although the role of dietary fat in cardiovascular disease is complex and controversial there is a long-standing consensus that replacing saturated fat with unsaturated fat in the diet is sound medical advice.[141]Total fat intake has not been found to be associated with cardiovascular risk.[142][143]A 2020 systematic review found moderate quality evidence that reducing saturated fat intake for at least 2 years caused a reduction in cardiovascular events.[144]A 2015 meta-analysis of observational studies however did not find a convincing association between saturated fat intake and cardiovascular disease.[145]Variation in what is used as a substitute for saturated fat may explain some differences in findings.[141]The benefit from replacement withpolyunsaturated fatsappears greatest,[146]while replacement of saturated fats withcarbohydratesdoes not appear to have a beneficial effect.[146]A diet high intrans fatty acidsis associated with higher rates of cardiovascular disease,[147]and in 2015 the Food and Drug Administration (FDA) determined that there was 'no longer a consensus among qualified experts that partially hydrogenated oils (PHOs), which are the primary dietary source of industrially produced trans fatty acids (IP-TFA), are generally recognized as safe (GRAS) for any use in human food'.[148]There is conflicting evidence concerning whether dietary supplements ofOmega -3 fatty acids(a type of polyunsaturated essential fatty acid) added to diet improve cardiovascular risk.[149][150]

The benefits of recommending alow-salt dietin people with high or normal blood pressure are not clear.[151]In those with heart failure, after one study was left out, the rest of the trials show a trend to benefit.[152][153]Another review of dietary salt concluded that there is strong evidence that high dietary salt intake increases blood pressure and worsens hypertension, and that it increases the number of cardiovascular disease events; both as a result of the increased blood pressureandprobably through other mechanisms.[154][155]Moderate evidence was found that high salt intake increases cardiovascular mortality; and some evidence was found for an increase in overall mortality, strokes, andleft ventricular hypertrophy.[154]

Intermittent fasting

Overall, the current body of scientific evidence is uncertain on whetherintermittent fastingcould prevent cardiovascular disease.[156]Intermittent fasting may help people lose more weight than regular eating patterns, but was not different from energy restriction diets.[156]

Medication

Blood pressure medication reduces cardiovascular disease in people at risk,[115]irrespective of age,[157]the baseline level of cardiovascular risk,[158]or baseline blood pressure.[159]The commonly-used drug regimens have similar efficacy in reducing the risk of all major cardiovascular events, although there may be differences between drugs in their ability to prevent specific outcomes.[160]Larger reductions in blood pressure produce larger reductions in risk,[160]and most people with high blood pressure require more than one drug to achieve adequate reduction in blood pressure.[161]Adherence to medications is often poor, and while mobile phone text messaging has been tried to improve adherence, there is insufficient evidence that it alters secondary prevention of cardiovascular disease.[162]

Statinsare effective in preventing further cardiovascular disease in people with a history of cardiovascular disease.[163]As the event rate is higher in men than in women, the decrease in events is more easily seen in men than women.[163]In those at risk, but without a history of cardiovascular disease (primary prevention), statins decrease the risk of death and combined fatal and non-fatal cardiovascular disease.[164]The benefit, however, is small.[165]A United States guideline recommends statins in those who have a 12% or greater risk of cardiovascular disease over the next ten years.[166]Niacin,fibratesandCETP Inhibitors,while they may increaseHDL cholesteroldo not affect the risk of cardiovascular disease in those who are already on statins.[167]Fibrates lower the risk of cardiovascular and coronary events, but there is no evidence to suggest that they reduce all-cause mortality.[168]

Anti-diabetic medicationmay reduce cardiovascular risk in people with Type 2 diabetes, although evidence is not conclusive.[169]A meta-analysis in 2009 including 27,049 participants and 2,370 major vascular events showed a 15%relative risk reductionin cardiovascular disease with more-intensive glucose lowering over an average follow-up period of 4.4 years, but an increased risk of majorhypoglycemia.[170]

Aspirinhas been found to be of only modest benefit in those at low risk of heart disease, as the risk of serious bleeding is almost equal to the protection against cardiovascular problems.[171]In those at very low risk, including those over the age of 70, it is not recommended.[172][173]TheUnited States Preventive Services Task Forcerecommends against use of aspirin for prevention in women less than 55 and men less than 45 years old; however, it is recommended for some older people.[174]

The use ofvasoactiveagents for people with pulmonary hypertension with left heart disease or hypoxemic lung diseases may cause harm and unnecessary expense.[175]

Antibiotics for secondary prevention of coronary heart disease

Antibiotics may help patients with coronary disease to reduce the risk of heart attacks and strokes.[176]However, evidence in 2021 suggests that antibiotics for secondary prevention of coronary heart disease are harmful, with increased mortality and occurrence of stroke;[176]the use of antibiotics is not supported for preventing secondary coronary heart disease.

Physical activity

Exercise-based cardiac rehabilitation following a heart attack reduces the risk of death from cardiovascular disease and leads to less hospitalizations.[177]There have been few high-quality studies of the benefits of exercise training in people with increased cardiovascular risk but no history of cardiovascular disease.[178]

A systematic review estimated that inactivity is responsible for 6% of the burden of disease from coronary heart disease worldwide.[179]The authors estimated that 121,000 deaths from coronary heart disease could have been averted in Europe in 2008 if people had not been physically inactive. Low-quality evidence from a limited number of studies suggest that yoga has beneficial effects on blood pressure and cholesterol.[180]Tentative evidence suggests that home-based exercise programs may be more efficient at improving exercise adherence.[181]

Dietary supplements

While ahealthy dietis beneficial, the effect ofantioxidantsupplementation (vitamin E,vitamin C,etc.) or vitamins has not been shown to protect against cardiovascular disease and in some cases may possibly result in harm.[182][183][184][185]Mineral supplements have also not been found to be useful.[186]Niacin,a type of vitamin B3, may be an exception with a modest decrease in the risk of cardiovascular events in those at high risk.[187][188]Magnesiumsupplementation lowers high blood pressure in a dose-dependent manner.[189]Magnesium therapy is recommended for people with ventriculararrhythmiaassociated withtorsades de pointeswho present withlong QT syndrome,and for the treatment of people with digoxin intoxication-induced arrhythmias.[190]There is no evidence thatOmega -3 fatty acidsupplementation is beneficial.[191]A 2022reviewfound that somedietary supplements,includingmicronutrients,may reduce risk factors for cardiovascular disease.[192]

Management

Cardiovascular disease is treatable with initial treatment primarily focused on diet and lifestyle interventions.[3]Influenzamay make heart attacks and strokes more likely and thereforeinfluenza vaccinationmay decrease the chance of cardiovascular events and death in people with heart disease.[193]

Proper CVD management necessitates a focus on MI and stroke cases due to their combined high mortality rate, keeping in mind the cost-effectiveness of any intervention, especially in developing countries with low or middle-income levels.[94]Regarding MI, strategies using aspirin, atenolol, streptokinase or tissue plasminogen activator have been compared for quality-adjusted life-year (QALY) in regions of low and middle income. The costs for a single QALY for aspirin and atenolol were less thanUS$25, streptokinase was about $680, and t-PA was $16,000.[194]Aspirin, ACE inhibitors, beta-blockers, and statins used together for secondary CVD prevention in the same regions showed single QALY costs of $350.[194]

There are also surgical or procedural interventions that can save someone's life or prolong it. For heart valve problems, a person could have surgery to replace the valve. For arrhythmias, apacemakercan be put in place to help reduce abnormal heart rhythms and for a heart attack, there are multiple options two of these are acoronary angioplastyand acoronary artery bypass surgery.[195]

There is probably no additional benefit in terms of mortality and serious adverse events when blood pressure targets were lowered to ≤ 135/85 mmHg from ≤ 140 to 160/90 to 100 mmHg.[196]

Epidemiology

Cardiovascular diseases deaths per million persons in 2012
318–925
926–1,148
1,149–1,294
1,295–1,449
1,450–1,802
1,803–2,098
2,099–2,624
2,625–3,203
3,204–5,271
5,272–10233
Disability-adjusted life year for cardiovascular diseases per 100,000 inhabitants in 2004[16]
no data
<900
900–1650
1650–2300
2300–3000
3000–3700
3700–4400
4400–5100
5100–5800
5800–6500
6500–7200
7200–7900
>7900

Cardiovascular diseases are the leading cause of death worldwide and in all regions except Africa.[3]In 2008, 30% of all global death was attributed to cardiovascular diseases. Death caused by cardiovascular diseases are also higher in low- and middle-income countries as over 80% of all global deaths caused by cardiovascular diseases occurred in those countries. It is also estimated that by 2030, over 23 million people will die from cardiovascular diseases each year.

It is estimated that 60% of the world's cardiovascular disease burden will occur in the South Asian subcontinent despite only accounting for 20% of the world's population. This may be secondary to a combination of genetic predisposition and environmental factors. Organizations such as theIndian Heart Associationare working with theWorld Heart Federationto raise awareness about this issue.[197]

Research

See also:Heart-on-a-chipandVessel-on-a-chip

There is evidence that cardiovascular disease existed in pre-history,[198]and research into cardiovascular disease dates from at least the 18th century.[199]The causes, prevention, and/or treatment of all forms of cardiovascular disease remain active fields ofbiomedical research,with hundreds of scientific studies being published on a weekly basis.

Recent areas of research include the link between inflammation and atherosclerosis[200]the potential for novel therapeutic interventions,[201]and the genetics of coronary heart disease.[202]

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