Cefonicid
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Clinical data | |
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AHFS/Drugs | Micromedex Detailed Consumer Information |
MedlinePlus | a601206 |
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Chemical and physical data | |
Formula | C18H18N6O8S3 |
Molar mass | 542.56g·mol−1 |
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Cefonicide(orcefonicid) is acephalosporinantibiotic.[1]
It has a density of 1.92g/cm3.
Synthesis
[edit]Injectable semi-synthetic cephalosporin antibiotic related tocefamandole,q.v.
![](https://upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Cefonicid_synthesis.svg/700px-Cefonicid_synthesis.svg.png)
Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of1with the appropriately substituted tetrazole thiole2.The mandelic acid amide C-7 side chain is reminiscent ofcefamandole.
See also
[edit]References
[edit]- ^Saltiel E, Brogden RN (September 1986). "Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use".Drugs.32(3): 222–59.doi:10.2165/00003495-198632030-00002.PMID3530703.S2CID243051006.
- ^DE 2611270,Berges, David Alan, "Cephalosporin-Derivate [Cephalosporin derivatives]", published 1976-09-30, assigned toSmithKline Corp.
- ^D. A. Berges,U.S. patent 4,048,311(1977 toSmith Kline).
- ^U.S. patent 4,093,723,U.S. patent 4,159,373(1978, 1979 both toSmith Kline).