Probable ATP-dependent RNA helicase DDX10is anenzymethat in humans is encoded by theDDX10gene.[5][6]
DEAD boxproteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number ofcellular processesinvolving alteration of RNAsecondary structuresuch as translation initiation, nuclear and mitochondrial splicing, andribosomeandspliceosomeassembly. Based on their distribution patterns, some members of this family are believed to be involved inembryogenesis,spermatogenesis,andcellular growthand division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and thenucleoporingene,NUP98,by inversion 11 (p15q22)chromosome translocationis found in the patients with de novo or therapy-relatedmyeloidmalignancies.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23".Genomics.33(2): 199–206.doi:10.1006/geno.1996.0184.PMID8660968.
Zuber J, Tchernitsa OI, Hinzmann B, et al. (2000). "A genome-wide survey of RAS transformation targets".Nat. Genet.24(2): 144–52.doi:10.1038/72799.PMID10655059.S2CID21887748.
Ikeda T, Ikeda K, Sasaki K, et al. (1999). "The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts".Int. J. Hematol.69(3): 160–4.PMID10222653.