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Dengue fever

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For other uses, seeDengue fever (disambiguation).

Dengue fever
Other namesDengue, breakbone fever[1][2]
Photograph of a person's back with the skin exhibiting the characteristic rash of dengue fever
Typical rash seen in dengue fever
Pronunciation
SpecialtyInfectious disease
SymptomsFever, headache, muscle and joint pain, rash. Can be severe, mild or asymptomatic[1][2]
ComplicationsBleeding,low levels of blood platelets,dangerously low blood pressure[2]
Usual onset3–14 days after exposure[2]
Duration2–7 days[1]
CausesDengue virusbyAedesmosquitos[1]
Diagnostic methodDetectingantibodiesto the virus or itsRNA[2]
Differential diagnosisMalaria,yellow fever,viral hepatitis,leptospirosis[5]
PreventionDengue fever vaccine,decreasing mosquito exposure[1][6]
TreatmentSupportive care,intravenous fluids,blood transfusions[2]
Frequency5 million per year (2023)[7]
Deaths5,000 per year (2023)[7]

Dengue feveris amosquito-bornediseasecaused bydengue virus,prevalent intropicalandsubtropicalareas. It is frequentlyasymptomatic;if symptoms appear they typically begin 3 to 14 days after infection. These may include a highfever,headache,vomiting,muscleandjoint pains,and a characteristic skin itching andskin rash.Recovery generally takes two to seven days. In a small proportion of cases, the disease develops intosevere dengue(previously known as dengue hemorrhagic fever or dengue shock syndrome)[8]withbleeding,low levels of blood platelets,blood plasmaleakage, anddangerously low blood pressure.[1][2]

Dengue virus has four confirmedserotypes;infection with one type usually gives lifelongimmunityto that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications.[9]The symptoms of dengue resemble many other diseases includingmalaria,influenza,andZika.[10]Blood tests are available to confirm the diagnosis including detecting viralRNA,orantibodiesto the virus.[11]

There is no specific treatment for dengue fever. In mild cases, treatment is focused on treating pain symptoms. Severe cases of dengue require hospitalisation; treatment of acute dengue is supportive and includes giving fluid either by mouth orintravenously.[1][2]

Dengue is spread by several species of femalemosquitoesof theAedesgenus,principallyAedes aegypti.[1]Infection can be prevented by mosquito elimination and the prevention of bites.[12]Two types ofdengue vaccinehave been approved and are commercially available. Dengvaxia became available in 2016 but it is only recommended to prevent re-infection in individuals who have been previously infected.[13]The second vaccine, Qdenga, became available in 2022 and is suitable for adults, adolescents and children from four years of age.[14]

The earliest descriptions of a dengue outbreak date from 1779; its viral cause and spread were understood by the early 20th century.[15]Alreadyendemicin more than one hundred countries, dengue is spreading from tropical and subtropical regions to the Iberian Peninsula and the southern states of the US, partly attributed to climate change.[7][16]It is classified as aneglected tropical disease.[17]During 2023, more than 5 million infections were reported, with more than 5,000 dengue-related deaths.[7]As most cases are asymptomatic or mild, the actual numbers of dengue cases and deaths are under-reported.[7]

Signs and symptoms

[edit]
Outline of a human torso with arrows indicating the organs affected in the various stages of dengue fever
Schematic depiction of the symptoms of dengue fever
Clinical course of dengue fever

Typically, people infected with dengue virus areasymptomatic(80%) or have only mild symptoms such as an uncomplicated fever.[18][19]Others have more severe illness (5%), and in a small proportion it is life-threatening.[18][19]Theincubation period(time between exposure and onset of symptoms) ranges from 3 to 14 days, but most often it is 4 to 7 days.[20]

The characteristic symptoms of mild dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, nausea, vomiting, swollen glands and a rash.[1][12]If this progresses to severe dengue the symptoms are severe abdominal pain, persistent vomiting, rapid breathing, bleeding gums or nose, fatigue, restlessness, blood in vomit or stool, extreme thirst, pale and cold skin, and feelings of weakness.[1]

Clinical course

[edit]

The course of infection is divided into three phases: febrile, critical, and recovery.[21]

The febrile phase involveshigh fever(40 °C/104 °F), and is associated with generalized pain and a headache; this usually lasts two to seven days.[22][1]There may also be nausea, vomiting, a rash, and pains in the muscle and joints.[1]

Most people recover within a week or so. In about 5% of cases, symptoms worsen and can become life-threatening. This is calledsevere dengue(formerly calleddengue hemorrhagic feverordengue shock syndrome).[21][23]Severe dengue can lead to shock, internal bleeding, organ failure and even death.[24]Warning signs include severe stomach pain, vomiting, difficulty breathing, and blood in the nose, gums, vomit or stools.[24]

During this period, there is leakage of plasma from the blood vessels, together with a reduction inplatelets.[24]This may result in fluid accumulation in thechestandabdominal cavityas well asdepletion of fluid from the circulationanddecreased blood supply to vital organs.[23]

The recovery phase usually lasts two to three days.[23]The improvement is often striking, and can be accompanied with severeitchingand aslow heart rate.[23]

The rash of dengue fever in the acute stage of the infectionblancheswhen pressed.
The rash that commonly forms during the recovery from dengue fever with its classic islands of white in a sea of red

Complications and sequelae

[edit]

Complicationsfollowing severe dengue include fatigue, somnolence, headache, concentration impairment and memory impairment.[21][25]A pregnant woman who develops dengue is at higher risk ofmiscarriage,low birth weight,andpremature birth.[26]

Children and older individuals are at a risk of developing complications from dengue fever compared to other age groups; young children typically suffer from more intense symptoms. Concurrent infections withtropical diseases[27]likeZika[28]virus can worsen symptoms and make recovery more challenging.[citation needed]

Cause

[edit]

Virology

[edit]
Main article:Dengue virus
A transmission electron microscopy image showing dengue virus
ATEMmicrographshowing dengue virusvirions(the cluster of dark dots near the center)

Dengue virus (DENV) is anRNA virusof the familyFlaviviridae;genusFlavivirus.Other members of the same genus includeyellow fever virus,West Nile virus,andZika virus. Dengue virusgenome(genetic material) contains about 11,000nucleotide bases,whichcodefor the threestructural proteinmolecules (C, prM and E) that form thevirus particleand seven other protein molecules that are required for replication of the virus.[29][30]There are four confirmed strains of the virus, calledserotypes,referred to as DENV-1, DENV-2, DENV-3 and DENV-4. The distinctions between the serotypes are based on theirantigenicity.[31]

Transmission

[edit]
Close-up photograph of an Aedes aegypti mosquito biting human skin
The mosquitoAedes aegyptifeeding on a human host

Dengue virus is most frequently transmitted by the bite of mosquitos in theAedesgenus, particularlyA. aegypti.[32]They prefer to feed at dusk and dawn,[33]but they may bite and thus spread infection at any time of day.[34]OtherAedesspecies that may transmit the disease includeA. albopictus,A. polynesiensisandA. scutellaris.Humans are the primaryhostof the virus,[35]but it also circulates in nonhumanprimates,and can infect other mammals.[36][37]An infection can be acquired via a single bite.[38]

For 2 to 10 days after becoming newly infected, a person's bloodstream will contain a high level of virus particles (theviremicperiod). A female mosquito that takes a blood meal from the infected host then propagates the virus in the cells lining its gut.[39]Over the next few days, the virus spreads to other tissues including the mosquito'ssalivary glandsand is released into its saliva. Next time the mosquito feeds, the infectious saliva will be injected into the bloodstream of its victim, thus spreading the disease.[40]The virus seems to have no detrimental effect on the mosquito, which remains infected for life.[20]

Dengue can also be transmitted via infectedblood productsand throughorgan donation.[1]Vertical transmission(from mother to child) during pregnancy or at birth has been reported.[41]

Risk factors

[edit]

The principal risk for infection with dengue is the bite of an infected mosquito.[42]This is more probable in areas where the disease is endemic, especially where there is high population density, poor sanitation, and standing water where mosquitoes can breed.[42]It can be mitigated by taking steps to avoid bites such as by wearing clothing that fully covers the skin, usingmosquito nettingwhile resting, and/or the application ofinsect repellent(DEETbeing the most effective).[38]

Chronic diseases – such as asthma, sickle cell anemia, and diabetes mellitus – increase the risk of developing a severe form of the disease.[43]Other risk factors for severe disease include female sex, and highbody mass index,[21][30]Infection with one serotype is thought to produce lifelong immunity to that type, but only short-term protection against the other three.[22]Subsequent re-infection with a different serotype increases the risk of severe complications due to phenomenon known asantibody-dependent enhancement(ADE).[9][44]

In antibody-dependent enhancement (ADE), antibodies bind to both viral particles and Fc gamma receptors expressed on immune cells, increasing the likelihood that the viruses will infect those cells.

The exact mechanism of ADE is not fully understood.[45]It appears that ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they fail to neutralize it. Instead, the antibody-virus complex has an enhanced ability to bind to theFcγreceptors of the target immune cells, enabling the virus to infect the cell and reproduce itself.[44][46]

Mechanism of infection

[edit]

When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. The virus infects nearby skin cells calledkeratinocytes,as well as specialized immune cell located in the skin, called aLangerhans cells.[47]The Langerhans cells migrate to thelymph nodes,where the infection spreads towhite blood cells,and reproduces inside the cells while they move throughout the body.[48]

The white blood cells respond by producing several signaling proteins, such ascytokinesandinterferons,which are responsible for many of the symptoms, such as the fever, the flu-like symptoms, and the severe pains. In severe infection, the virus production inside the body is greatly increased, and many more organs (such as theliverand thebone marrow) can be affected. Fluid from the bloodstream leaks through the wall of small blood vessels into body cavities due to increasedcapillary permeability.As a result,blood volumedecreases, and the blood pressure becomes so low that it cannot supply sufficient blood to vital organs. The spread of the virus to the bone marrow leads to reduced numbers of platelets, which are necessary for effective blood clotting; this increases the risk of bleeding, the other major complication of dengue fever.[48]

Prevention

[edit]

Vector control

[edit]
A black and white photograph of people filling in a ditch with standing water
A 1920s photograph of efforts to disperse standing water and thus decrease mosquito populations
Main article:Mosquito control

The principal risk for infection with dengue is the bite of an infected mosquito.[1]This is more probable in areas where the disease is endemic, especially where there is high population density, poor sanitation, and standing water where mosquitoes can breed.[42]It can be mitigated by taking steps to avoid bites such as by wearing clothing that fully covers the skin, using mosquito netting while resting, and/or the application of insect repellent (DEET being the most effective);[49]it is also advisable to treat clothing, nets and tents with 0.5%permethrin.[50]

Protection of the home can be achieved with door and window screens, by using air conditioning, and by regularly emptying and cleaning all receptacles both indoors and outdoors which may accumulate water (such as buckets, planters, pools or trashcans).[50]

The primary method of controllingA. aegyptiis by eliminating itshabitats.This is done by eliminating open sources of water, or if this is not possible, by addinginsecticidesorbiological control agentsto these areas. Generalized spraying withorganophosphateorpyrethroidinsecticides, while sometimes done, is not thought to be effective.[51]Reducing open collections of water through environmental modification is the preferred method of control, given the concerns of negative health effects from insecticides and greater logistical difficulties with control agents. Ideally, mosquito control would be a community activity, e.g. when all members of a community clear blocked gutters and street drains and keep their yards free of containers with standing water.[52]If residences have direct water connections this eliminates the need for wells or street pumps and water-carrying containers.[52]

Vaccine

[edit]
Main article:Dengue vaccine

As of March 2024, there are two vaccines to protect against dengue infection; Dengvaxia and Qdenga.[53]

Subcutaneous injection
Illustration of a subcutaneous injection

Dengvaxia(formerly CYD-TDV) became available in 2015, and is approved for use in the US, EU and in some Asian and Latin American countries.[54]It is an attenuated virus, is suitable for individuals aged 6–45 years and protects against all four serotypes of dengue.[55]Due to safety concerns aboutantibody-dependent enhancement(ADE), it should only be given to individuals who have previously been infected with dengue, in order to protect them from reinfection.[56]It is given subcutaneously as three doses at six month intervals.[57]

Qdenga(formerly TAK-003) completed clinical trials in 2022 and was approved for use in the European Union in December 2022;[53]it has been approved by a number of other countries including Indonesia and Brazil, and has been recommended by theSAGE committeeof the World Health Organization.[58]It is indicated for the prevention of dengue disease in individuals four years of age and older, and can be administered to people who have not been previously infected with dengue. It is a liveattenuatedvaccine containing the four serotypes of dengue virus, administered subcutaneously as two doses three months apart.[53]

Severe disease

[edit]

TheWorld Health Organization'sInternational Classification of Diseasesdivides dengue fever into two classes: uncomplicated and severe.[18]Severe dengueis defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage.[59]

Severe dengue can develop suddenly, sometimes after a few days as the fever subsides.[24]Leakage of plasma from the capillaries results in extremelow blood pressureandhypovolemic shock;Patients with severe plasma leakage may have fluid accumulation in thelungsorabdomen,insufficient protein in the blood,orthickening of the blood.Severe dengue is a medical emergency which can cause damage to organs, leading to multiple organ failure and death.[60]

Diagnosis

[edit]

Mild cases of dengue fever can easily be confused with several common diseases includingInfluenza,measles,chikungunya,andzika.[61][62]Dengue, chikungunya and zika share the same mode of transmission (Aedesmosquitoes) and are often endemic in the same regions, so that it is possible to beinfected simultaneouslyby more than one disease.[63]For travellers, dengue fever diagnosis should be considered in anyone who develops a fever within two weeks of being in thetropicsorsubtropics.[21]

Graph of when laboratory tests for dengue fever become positive. Day zero refers to the start of symptoms, 1st refers to in those with a primary infection, and 2nd refers to in those with a secondary infection.[21]

Warning symptoms of severe dengue include abdominal pain, persistent vomiting, odema, bleeding, lethargy, and liver enlargement. Once again, these symptoms can be confused with other diseases such as malaria, gastroenteritis, leptospirosis, and typhus.[61]

Blood tests can be used to confirm a diagnosis of dengue. During the first few days of infection, enzyme-linked immunosorbent assay (ELISA) can be used to detect theNS1 antigen;however this antigen is produced by all flaviviruses.[63][11]Four or five days into the infection, it is possible to reliably detect anti-dengueIgMantibodies, but this does not determine the serotype.[63]Nucleic acid amplification testsprovide the most reliable method of diagnosis.[11]

Treatment

[edit]

As of July 2024, there is no specific antiviral treatment available for dengue fever.[64]

Most cases of dengue fever have mild symptoms, and recovery takes place in a few days.[1]No treatment is required for these cases.Acetaminophen(Paracetamol,Tylenol) may be used to relieve mild fever or pain. Other common pain relievers, includingaspirin,ibuprofen(Advil, Motrin IB, others) andnaproxen sodium(Aleve) should be avoided as they can increase the risk of bleeding complications.[64]

For moderate illness, those who can drink, are passing urine, have no warning signs and are otherwise reasonably healthy can be monitored carefully at home.Supportive carewith analgesics, fluid replacement, and bed rest are recommended.[65][23]

Severe dengue is a life-threatening emergency, requiring hospitalization and potentially intensive care.[24]Warning signs includedehydration,decreasing platelets and increasinghematocrit.[66]Treatment modes include intravenous fluids, and transfusion with platelets or plasma.[65]

Prognosis

[edit]

Most people with dengue recover without any ongoing problems. The risk of death among those with severe dengue is 0.8–2.5%,[67]and with adequate treatment this is less than 1%. However, those who develop significantly low blood pressure may have a fatality rate of up to 26%.[23]The risk of death among children less than five years old is four times greater than among those over the age of 10.[67]Elderly people are also at higher risk of a poor outcome.[67]

Epidemiology

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See also:Dengue fever outbreaks
Dengue fever deaths per million persons in 2012
0
1
2
3
4–8
9–561

As of March 2023, dengue isendemicin more than 100 countries with cases reported in every continent with the exception of Antarctica.[1][68]The Americas, Southeast Asia and the Western Pacific regions are the most seriously affected.[1][69]It is difficult to estimate the full extent of the disease, as many cases are mild and not correctly diagnosed. WHO currently estimates that 3.9 billion people are at risk of dengue infection.[1][69]In 2013, it was estimated that 390 million dengue infections occur every year, with 500,000 of these developing severe symptoms and 25,000 deaths.[70][71]

External image
An online map showing reports of dengue fever
image iconhttps:// healthmap.org/dengue/en/

Generally, areas where dengue is endemic have only one serotype of the virus in circulation. The disease is said to behyperendemicin areas where more than one serotype is circulating; this increases the risk of severe disease on a second or subsequent infection.[72]

Infections are most commonly acquired in urban environments where the virus is primarily transmitted by the mosquito speciesAedes aegypti.[73]This species has adapted to the urban environment, is generally found close to human habitation, prefers humans as its host, and takes advantage of small bodies of standing water (such astanksand buckets) in which to breed. In rural settings the virus is transmitted to humans byA. aegyptiand other related mosquitoes such asAedes albopictus.[73]Both these species have expanding ranges.[21]There are two subspecies ofAedes aegypti,whereAedes aegypti formosuscan be found in natural habitats such as forests andAedes Aegypti aegyptihas adapted to urban domestic habitats.[74]

Dengue has increased in incidence in recent decades, with WHO recording a ten fold increase between 2010 and 2019 (from 500,000 to 5 million recorded cases).[1]This increase is tied closely to the increasing range of Aedes mosquitoes, which is attributed to a combination ofurbanization,population growth, andan increasingly warm climate.[75][76]In endemic areas, dengue infections peak when rainfall is optimal for mosquito breeding.[77]In October 2023, the first confirmed symptomatic case of locally acquired dengue (i.e. not while travelling) in the US was identified in California.[78]

The disease infects all races, sexes, and ages equally. In endemic areas, the infection is most commonly seen in children who then acquire a lifelong partial immunity.[71]

History

[edit]

The first historical record of a case of probable dengue fever is in a Chinese medical encyclopedia from theJin dynasty (266–420)which referred to a "water poison" associated with flying insects.[79][80]

The principal mosquito vector of dengue,Aedes aegypti,spread out of Africa in the 15th to 19th centuries due to theslave tradeand consequent expansion of international trading.[21]There have been descriptions of epidemics of dengue-like illness in the 17th century, and it is likely that epidemics inJakarta,Cairo,andPhiladelphiaduring the 18th century were caused by dengue.[79][81]

It is assumed that dengue wasconstantly presentin many tropical urban centres throughout the 19th and early 20th centuries, even though significant outbreaks were infrequent.[79]The marked spread of dengue during and after theSecond World Warhas been attributed partly to disruption caused by the war, and partly to subsequent urbanisation in south-east Asia.[79]As novel serotypes were introduced to regions already endemic with dengue, outbreaks of severe disease followed. The severe hemorrhagic form of the disease was first reported in thePhilippinesin 1953; by the 1970s, it had become recognised as a major cause ofchild mortalityin Southeast Asia.[79]

In Central and South America, the Aedes mosquito had been eradicated in the 1950s; however the eradication program was discontinued in the 1970s and the disease re-established itself in the region during the 1980s, becoming hyperendemic and causing significant epidemics.[79]

Dengue has continued to increase in prevalence during the 21st century, as the mosquito vector continues to expand its range. This is attributed partly to continuing urbanisation, and partly to the impact of a warmer climate.[82]

Etymology

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The name came into English in the early 19th century fromWest Indian Spanish,which borrowed it from theKiswahilitermdinga/denga,meaning "cramp-like seizure" – the full term of the condition beingki-dinga pepo:"a sort of cramp-like seizure (caused by) an evil spirit".[83]The borrowed term changed todenguein Spanish due to this word existing in Spanish with the meaning "fastidiousness" and thisfolk etymologyreferring to the dislike of movement by affected patients.[4][84]Slaves in the West Indies having contracted dengue were said to have the posture and gait of adandy,and the disease was known as "dandy fever".[85][86]

The termbreak-bone feverwas applied by physician andUnited States Founding FatherBenjamin Rush,in a 1789 report of the 1780 epidemic inPhiladelphia,due to the associated muscle and joint pains. In the report title he uses the more formal term "bilious remitting fever".[87]The term dengue fever came into general use only after 1828.[86]Other historical terms include "breakheart fever" and "la dengue".[86]Terms for severe disease include "infectious thrombocytopenic purpura" and "Philippine", "Thai", or "Singapore hemorrhagic fever".[86]

Research

[edit]

Research directions include denguepathogenesis(the process by which the disease develops in humans), as well as the biology, ecology and behaviour of the mosquito vector. Improveddiagnosticswould enable faster and more appropriate treatment.[88]Attempts are ongoing to develop anantiviralmedicine targeting the NS3 or NS5 proteins.[89]

In addition to the two vaccines which are already available, several vaccine candidates are in development.[90]

Society and culture

[edit]

Blood donation

[edit]

Outbreaks of dengue fever increase the need for blood products while decreasing the number of potentialblood donorsdue to potential infection with the virus.[91]Someone who has a dengue infection is typically not allowed to donate blood for at least the next six months.[91]

Public awareness

[edit]
A poster inTampines,Singapore, notifying people that there are ten or more cases of dengue in the neighbourhood (November 2015)

International Anti-Dengue Day is observed every year on 15 June in a number of countries.[92]The idea was first agreed upon in 2010 with the first event held inJakarta,Indonesia, in 2011.[92]Further events were held in 2012 inYangon,Myanmar, and in 2013 inVietnam.[92]Goals are to increase public awareness about dengue, mobilize resources for its prevention and control and, to demonstrate the Southeast Asian region's commitment in tackling the disease.[93]Efforts are ongoing as of 2019 to make it a global event.[94]

The Philippines has an awareness month in June since 1998.[95][96]

A National Dengue Day is held in India annually on 16 May.[97]

Economic burden

[edit]

A study estimated that the global burden of dengue in 2013 amounted to US$8.9 billion.[98]

See also

[edit]

References

[edit]
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