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Heavy water

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(Redirected fromDeuterium oxide)
Not to be confused withHard waterorTritiated water.

Heavy water
Spacefill model of heavy water
Spacefill model of heavy water
Names
IUPAC name
(2H2)Water[4]
Other names
  • Deuterium oxide[1]
  • Water-d2[2]
  • Dideuterium monoxide
  • Deuterated water[3]
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.029.226Edit this at Wikidata
EC Number
  • 232-148-9
97
KEGG
MeSH Deuterium+Oxide
RTECS number
  • ZC0230000
UNII
  • InChI=1S/H2O/h1H2/i/hD2☒N
    Key: XLYOFNOQVPJJNP-ZSJDYOACSA-N☒N
  • [2H]O[2H]
Properties
D
2O
Molar mass 20.0276 g mol−1
Appearance Colorless liquid
Odor Odorless
Density 1.107 g mL−1
Melting point 3.82 °C; 38.88 °F; 276.97 K
Boiling point 101.4 °C (214.5 °F; 374.5 K)
Miscible
logP −1.38
1.328
Viscosity 1.25 mPa s (at 20 °C)
1.87 D
Hazards
NFPA 704(fire diamond)
NFPA 704 four-colored diamondHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
0
0
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
☒N(what ischeckY☒N?)

Heavy water(deuterium oxide,2
H
2O,D
2O) is a form ofwaterwhose hydrogen atoms are alldeuterium(2
Hor D, also known asheavy hydrogen) rather than the common hydrogen-1isotope(1
H,also calledprotium) that makes up most of the hydrogen in normal water.[3]The presence of the heavier isotope gives the water different nuclear properties, and the increase in mass gives it slightly different physical and chemical properties when compared to normal water.

Deuterium is a heavyhydrogen isotope.Heavy water contains deuterium atoms and is used innuclear reactors.Semiheavy water (HDO) is more common than pure heavy water, while heavy-oxygen water is denser but lacks unique properties. Tritiated water is radioactive due totritiumcontent.

Heavy water has different physical properties from regular water, such as being 10.6% denser and having a higher melting point. Heavy water is less dissociated at a given temperature, and it does not have the slightly blue color of regular water. While it has no significant taste difference, it can taste slightly sweet. Heavy water affects biological systems by altering enzymes, hydrogen bonds, and cell division ineukaryotes.It can be lethal to multicellular organisms at concentrations over 50%. However, someprokaryoteslikebacteriacan survive in a heavy hydrogen environment. Heavy water can be toxic to humans, but a large amount would be needed for poisoning to occur.

Deuterated water (HDO) occurs naturally in normal water and can be separated through distillation, electrolysis, or chemical exchange processes. The most cost-effective process for producing heavy water is theGirdler sulfide process.Heavy water is used in various industries and is sold in different grades of purity. Some of its applications includenuclear magnetic resonance,infrared spectroscopy,neutron moderation,neutrino detection,metabolic rate testing,neutron capture therapy,and the production of radioactive materials such asplutoniumand tritium.

Composition

[edit]

The deuteriumnucleusconsists of aneutronand aproton;the nucleus of a protium (normal hydrogen) atom consists of just a proton. The additional neutron makes a deuterium atom roughly twice as heavy as a protium atom.

A molecule of heavy water has two deuterium atoms in place of the two protium atoms of ordinary water. The term heavy water as defined by theIUPACGold Book[5]can also refer to water in which a higher than usual proportion of hydrogen atoms are deuterium. For comparison,Vienna Standard Mean Ocean Water(the "ordinary water" used for a deuterium standard) contains about 156 deuterium atoms per million hydrogen atoms; that is, 0.0156% of the hydrogen atoms are2H. Thus heavy water as defined by the Gold Book includessemiheavy water(hydrogen-deuterium oxide, HDO) and other mixtures ofD
2O,H
2O,and HDO in which the proportion of deuterium is greater than usual. For instance, the heavy water used inCANDU reactorsis a highly enriched water mixture that is mostly deuterium oxideD
2O,but also some hydrogen-deuterium oxide and a smaller amount of ordinary waterH
2O.It is 99.75% enriched by hydrogen atom-fraction; that is, 99.75% of the hydrogen atoms are of the heavy type; however, heavy water in the Gold Book sense need not be so highly enriched. The weight of a heavy water molecule, however, is not very different from that of a normal water molecule, because about 89% of the mass of the molecule comes from the singleoxygenatom rather than the two hydrogens.

Heavy water is notradioactive.In its pure form, it has a density about 11% greater than water but is otherwise physically and chemically similar. Nevertheless, the various differences in deuterium-containing water (especially affecting the biological properties) are larger than in any other commonly occurringisotope-substituted compoundbecause deuterium is unique among heavystable isotopesin being twice as heavy as the lightest isotope. This difference increases thestrengthof water's hydrogen–oxygen bonds, and this in turn is enough to cause differences that are important to some biochemical reactions. The human body naturally contains deuterium equivalent to about five grams of heavy water, which is harmless. When a large fraction of water (> 50%) in higher organisms is replaced by heavy water, the result iscelldysfunction and death.[6]

Heavy water was first produced in 1932, a few months after the discovery of deuterium.[7]With the discovery ofnuclear fissionin late 1938, and the need for aneutron moderatorthat captured few neutrons, heavy water became a component of earlynuclear energyresearch. Since then, heavy water has been an essential component in some types of reactors, both those that generate power and those designed to produce isotopes for nuclear weapons. Theseheavy water reactorshave the advantage of being able to run on naturaluraniumwithout usinggraphitemoderators that pose radiological[8]anddust explosion[9]hazards in the decommissioning phase. The graphite moderated SovietRBMKdesign tried to avoid using eitherenriched uraniumor heavy water (being cooled with ordinary water instead) which produced the positivevoid coefficientthat was one of a series of flaws in reactor design leading to theChernobyl disaster.Most modern reactors use enriched uranium with ordinary water as the moderator.

Other heavy forms of water

[edit]

Semiheavy water

[edit]
Structure of semiheavy water

Semiheavy water,HDO, exists whenever there is water with light hydrogen (protium,1
H) and deuterium (D or2
H) in the mix. This is because hydrogen atoms (1H and2H) are rapidly exchanged between water molecules. Water containing 50%1
Hand 50%2
Hin its hydrogen, is actually about 50% HDO and 25% each ofH
2OandD
2O,indynamic equilibrium. In normal water, about 1 molecule in 3,200 is HDO (one hydrogen in 6,400 is2
H), and heavy water molecules (D
2O) only occur in a proportion of about 1 molecule in 41 million (i.e. one in 6,4002)[citation needed].Thus semiheavy water molecules are far more common than "pure" (homoisotopic) heavy water molecules.

Heavy-oxygen water

[edit]

Water enriched in the heavier oxygen isotopes17
Oand18
Ois also commercially available. It is "heavy water" as it is denser than normal water (H
218
Ois approximately as dense asD
2O,H
217
Ois about halfway betweenH
2OandD
2O)—but is rarely called heavy water, since it does not contain the excess deuterium that gives D2O its unusual nuclear and biological properties. It is more expensive than D2O due to the more difficult separation of17O and18O.[10]H218O is also used for production offluorine-18inradiopharmaceuticalsandradiotracers,andpositron emission tomography.Small amounts of17
Oand18
Oare naturally present in water, and most processes enriching heavy water also enrich heavier isotopes of oxygen as a side-effect. This is undesirable if the heavy water is to be used as a neutron moderator in nuclear reactors, as17
Ocan undergo neutron capture, followed by emission of anAlpha particle,producing radioactive14
C.However,doubly labeled water,containing both a heavy oxygen and hydrogen, is useful as a non-radioactive isotopic tracer.

Compared to the isotopic change of hydrogen atoms, the isotopic change of oxygen has a smaller effect on the physical properties.[11]

Tritiated water

[edit]

Tritiated watercontainstritium(3H) in place of protium (1H) or deuterium (2H). Since tritium is radioactive, tritiated water is also radioactive.

Physical properties

[edit]
Physical properties of isotopologues of water[12]
Property T2O (Tritiated water) D2O (Heavy water) HDO (Semiheavy water) H2O (Light water)
Melting point(standard pressure) 4.49 °C (40.08 °F; 277.64 K) 3.82 °C (38.88 °F; 276.97 K) 2.04 °C (35.67 °F; 275.19 K) 0.0 °C (32.0 °F; 273.1 K)
Boiling point 101.5 °C (214.7 °F; 374.6 K) 101.4 °C (214.5 °F; 374.5 K) 100.7 °C (213.3 °F; 373.8 K) 100.0 °C (212.0 °F; 373.1 K)
DensityatSTP(g/mL) 1.2133 1.1056 1.054 0.9982
Temp. of maximum density 13.4 °C 11.6 °C Unverified 3.98 °C[13]
Dynamic viscosity(at 20 °C,mPa·s) 1.40 (estimated) 1.2467 1.1248 1.0016
Surface tension(at 25 °C,N/m) Unverified 0.07187 0.07193 0.07198
Heat of fusion(kJ/mol) Unverified 6.132 6.227 6.00678
Heat of vaporisation(kJ/mol) Unverified 41.521 Unverified 40.657
pH(at 25 °C)[14] Unverified 7.44 ( "pD" ) 7.266 ( "pHD" ) 7.0
pKb(at 25 °C)[14] Unverified 7.44 ( "pKbD2O ") Unverified 7.0
Refractive index(at 20 °C, 0.5893μm)[15] Unverified 1.32844 Unverified 1.33335

The physical properties of water and heavy water differ in several respects. Heavy water is less dissociated than light water at given temperature, and the true concentration of D+ions is less than H+ions would be for light water at the same temperature. The same is true of OD−vs. OH−ions. For heavy water Kw D2O (25.0 °C) = 1.35 × 10−15,and [D+ ] must equal [OD− ] for neutral water. Thus pKw D2O = p[OD−] + p[D+] = 7.44 + 7.44 = 14.87 (25.0 °C), and the p[D+] of neutral heavy water at 25.0 °C is 7.44.

The pD of heavy water is generally measured using pH electrodes giving a pH (apparent) value, or pHa, and at various temperatures a true acidic pD can be estimated from the directly pH meter measured pHa, such that pD+ = pHa (apparent reading from pH meter) + 0.41. The electrode correction for alkaline conditions is 0.456 for heavy water. The alkaline correction is then pD+ = pHa(apparent reading from pH meter) + 0.456. These corrections are slightly different from the differences in p[D+] and p[OD-] of 0.44 from the corresponding ones in heavy water.[16]

Heavy water is 10.6% denser than ordinary water, and heavy water's physically different properties can be seen without equipment if a frozen sample is dropped into normal water, as it will sink. If the water is ice-cold the higher melting temperature of heavy ice can also be observed: it melts at 3.7 °C, and thus does not melt in ice-cold normal water.[17]

A 1935 experiment reported not the "slightest difference" in taste between ordinary and heavy water.[18]However, a more recent study confirmed anecdotal observation that heavy water tastes slightly sweet to humans, with the effect mediated by theTAS1R2/TAS1R3taste receptor.[19]Rats given a choice between distilled normal water and heavy water were able to avoid the heavy water based on smell, and it may have a different taste.[20]Some people report that minerals in water affect taste, e.g. potassium lending a sweet taste to hard water, but there are many factors of a perceived taste in water besides mineral contents.[21]

Heavy water lacks thecharacteristic blue colorof light water; this is because themolecular vibrationharmonics, which in light water cause weak absorption in the red part of the visible spectrum, are shifted into theinfraredand thus heavy water does not absorb red light.[22]

No physical properties are listed for "pure" semi-heavy water because it is unstable as a bulk liquid. In the liquid state, a few water molecules are always in anionized state,which means the hydrogen atoms can exchange among different oxygen atoms. Semi-heavy water could, in theory, be created via a chemical method,[further explanation needed]but it would rapidly transform into a dynamic mixture of 25% light water, 25% heavy water, and 50% semi-heavy. However, if it were made in the gas phase and directlydepositedinto a solid, semi-heavy water in the form of ice could be stable. This is due to collisions between water vapor molecules being almost completely negligible in the gas phase at standard temperatures, and once crystallized, collisions between the molecules cease altogether due to the rigid lattice structure of solid ice.[citation needed]

History

[edit]

The US scientist andNobel laureateHarold Ureydiscovered the isotopedeuteriumin 1931 and was later able to concentrate it in water.[23]Urey's mentorGilbert Newton Lewisisolated the first sample of pure heavy water byelectrolysisin 1933.[24]George de Hevesyand Erich Hofer used heavy water in 1934 in one of the first biological tracer experiments, to estimate the rate of turnover of water in the human body.[25]The history of large-quantity production and use of heavy water, in early nuclear experiments, is described below.[26]

Emilian BratuandOtto Redlichstudied the autodissociation of heavy water in 1934.[27]

Effect on biological systems

[edit]

Different isotopes of chemical elements have slightly different chemical behaviors, but for most elements the differences are far too small to have a biological effect. In the case of hydrogen, larger differences in chemical properties among protium, deuterium, and tritium occur because chemical bond energy depends on thereduced massof the nucleus–electron system; this is altered in heavy-hydrogen compounds (hydrogen-deuterium oxide is the most common) more than for heavy-isotope substitution involving other chemical elements. The isotope effects are especially relevant in biological systems, which are very sensitive to even the smaller changes, due to isotopically influenced properties of water when it acts as asolvent.

To perform their tasks,enzymesrely on their finely tuned networks ofhydrogen bonds,both in the active center with their substrates and outside the active center, to stabilize theirtertiary structures.As a hydrogen bond with deuterium is slightly stronger[28]than one involving ordinary hydrogen, in a highly deuterated environment, some normal reactions in cells are disrupted.

Particularly hard-hit by heavy water are the delicate assemblies ofmitotic spindleformations necessary forcell divisionineukaryotes.Plants stop growing and seeds do not germinate when given only heavy water, because heavy water stops eukaryotic cell division.[29]Tobacco does not germinate, but wheat does.[30]The deuterium cell is larger and is a modification of the direction of division.[31][32]The cell membrane also changes, and it reacts first to the impact of heavy water. In 1972, it was demonstrated that an increase in the percentage of deuterium in water reduces plant growth.[33]Research conducted on the growth ofprokaryotemicroorganisms in artificial conditions of a heavy hydrogen environment showed that in this environment, all the hydrogen atoms of water could be replaced with deuterium.[34][35]Experiments showed that bacteria can live in 98% heavy water.[36]Concentrations over 50% are lethal to multicellular organisms, however a few exceptions are known: plant species such as switchgrass (Panicum virgatum) which is able to grow on 50% D2O;[37]Arabidopsis thaliana(70% D2O);[38]Vesicularia dubyana(85% D2O);[39]Funaria hygrometrica(90% D2O);[40]and theanhydrobioticspecies ofnematodePanagrolaimus superbus(nearly 100% D2O).[41]

A comprehensive study of heavy water on the fission yeastSchizosaccharomyces pombeshowed that the cells displayed an altered glucose metabolism and slow growth at high concentrations of heavy water.[42]In addition, the cells activated the heat-shock response pathway and the cell integrity pathway, and mutants in the cell integrity pathway displayed increased tolerance to heavy water.[42]Despite its toxicity at high levels, heavy water has been observed to extend lifespan of certain yeasts by up to 85%, with the hypothesized mechanism being the reduction of reactive oxygen species turnover.[43]

Heavy water affects the period ofcircadian oscillations,consistently increasing the length of each cycle. The effect has been demonstrated in unicellular organisms, green plants, isopods, insects, birds, mice, and hamsters. The mechanism is unknown.[44]

Like ethanol, heavy water temporarily changes the relative density of cupula relative to the endolymph in the vestibular organ, causingpositional nystagmus,illusions of bodily rotations, dizziness, and nausea. However, the direction of nystagmus is in the opposite direction of ethanol, since it is denser than water, not lighter.[45]

Effect on animals

[edit]

Experiments with mice, rats, and dogs[46]have shown that a degree of 25% deuteration causes (sometimes irreversible) sterility, because neithergametesnorzygotescan develop. High concentrations of heavy water (90%) rapidly kill fish,tadpoles,flatworms,andDrosophila.Mice raised from birth with 30% heavy water have 25% deuteration in body fluid and 10% in brains. They are normal except for sterility. Deuteration during pregnancy induces fetal abnormality. Higher deuteration in body fluid causes death.[47]Mammals (for example, rats) given heavy water to drink die after a week, at a time when their body water approaches about 50% deuteration.[48]The mode of death appears to be the same as that incytotoxic poisoning(such aschemotherapy) or in acute radiation syndrome (though deuterium is not radioactive), and is caused by deuterium's action in generally inhibiting cell division. It is more toxic to malignant cells than normal cells, but the concentrations needed are too high for regular use.[46]As may occur in chemotherapy, deuterium-poisoned mammals die of a failure of bone marrow (producing bleeding and infections) and of intestinal-barrier functions (producingdiarrheaandloss of fluids).

Despite the problems of plants and animals in living with too much deuterium, prokaryotic organisms such as bacteria, which do not have the mitotic problems induced by deuterium, may be grown and propagated in fully deuterated conditions, resulting in replacement of all hydrogen atoms in the bacterial proteins and DNA with the deuterium isotope.[46][49]This leads to a process of bootstrapping. With prokaryotes producing fully deuterated glucose, fully deuteratedEscherichia coliandTorulawere raised, and they could produce even more complex fully deuterated chemicals. Molds likeAspergilluscould not replicate under fully deuterated conditions.[47]

In higher organisms, full replacement with heavy isotopes can be accomplished with other non-radioactive heavy isotopes (such as carbon-13, nitrogen-15, and oxygen-18), but this cannot be done for deuterium. This is a consequence of the ratio of nuclear masses between the isotopes of hydrogen, which is much greater than for any other element.[50]

Deuterium oxide is used to enhanceboron neutron capture therapy,but this effect does not rely on the biological or chemical effects of deuterium, but instead on deuterium's ability to moderate (slow) neutrons without capturing them.[46]2021 experimental evidence indicates that systemic administration of deuterium oxide (30% drinking water supplementation) suppressestumorgrowth in a standard mouse model of humanmelanoma,an effect attributed to selective induction of cellular stress signaling and gene expression in tumor cells.[51]

Toxicity in humans

[edit]

Because it would take a very large amount of heavy water to replace 25% to 50% of a human being's body water (water being in turn 50–75% of body weight[52]) with heavy water, accidental or intentionalpoisoningwith heavy water is unlikely to the point of practical disregard. Poisoning would require that the victim ingest large amounts of heavy water without significant normal water intake for many days to produce any noticeable toxic effects.

Oral doses of heavy water in the range of several grams, as well asheavy oxygen18O, are routinely used in human metabolic experiments. (Seedoubly labeled watertesting.) Since one in about every 6,400 hydrogen atoms is deuterium, a 50-kilogram (110 lb) human containing 32 kilograms (71 lb) of body water would normally contain enough deuterium (about 1.1 grams or 0.039 ounces) to make 5.5 grams (0.19 oz) of pure heavy water, so roughly this dose is required to double the amount of deuterium in the body.

A loss of blood pressure may partially explain the reported incidence of dizziness upon ingestion of heavy water. However, it is more likely that this symptom can be attributed to alteredvestibular function.Heavy water, like ethanol, causes temporary difference in density of cupula and endolymph, which confuses thevestibulo–ocular reflexand causes motion sickness symptoms.[53]

Heavy water radiation contamination confusion

[edit]

Although many people associate heavy water primarily with its use in nuclear reactors, pure heavy water is not radioactive. Commercial-grade heavy water is slightly radioactive due to the presence of minute traces of natural tritium, but the same is true of ordinary water. Heavy water that has been used as a coolant in nuclear power plants contains substantially more tritium as a result of neutron bombardment of the deuterium in the heavy water (tritium is a health riskwhen ingested in large quantities).

In 1990, a disgruntled employee at thePoint Lepreau Nuclear Generating Stationin Canada obtained a sample (estimated as about a "half cup" ) of heavy water from the primary heat transport loop of thenuclear reactor,and loaded it into a cafeteria drink dispenser. Eight employees drank some of the contaminated water. The incident was discovered when employees began leavingbioassayurine samples with elevatedtritiumlevels. The quantity of heavy water involved was far below levels that could induce heavy water toxicity, but several employees received elevated radiation doses from tritium and neutron-activated chemicals in the water.[54]This was not an incident of heavy water poisoning, but rather radiation poisoning from other isotopes in the heavy water.

Some news services were not careful to distinguish these points, and some of the public were left with the impression that heavy water is normally radioactive and more severely toxic than it actually is. Even if pure heavy water had been used in the water cooler indefinitely, it is not likely the incident would have been detected or caused harm, since no employee would be expected to get much more than 25% of their daily drinking water from such a source.[55]

Production

[edit]

OnEarth,deuterated water occurs naturally in normal water at a proportion of about 1 molecule in 3,200. This means that 1 in 6,400 hydrogen atoms in water is deuterium, which is 1 part in 3,200 by weight (hydrogen weight). The HDO may be separated from normal water bydistillationorelectrolysisand also by various chemical exchange processes, all of which exploit akinetic isotope effect,with the partial enrichment also occurring in natural bodies of water under particular evaporation conditions.[56](For more information about the isotopic distribution of deuterium in water, seeVienna Standard Mean Ocean Water.) In theory, deuterium for heavy water could be created in a nuclear reactor, but separation from ordinary water is the cheapest bulk production process.

The difference in mass between the two hydrogen isotopes translates into a difference in thezero-point energyand thus into a slight difference in the speed of the reaction. Once HDO becomes a significant fraction of the water, heavy water becomes more prevalent as water molecules trade hydrogen atoms very frequently. Production of pure heavy water by distillation or electrolysis requires a large cascade of stills or electrolysis chambers and consumes large amounts of power, so the chemical methods are generally preferred.

The most cost-effective process for producing heavy water is the dual temperature exchange sulfide process (known as theGirdler sulfide process) developed in parallel byKarl-Hermann GeibandJerome S. Spevackin 1943.[57]An alternative process,[58]patented by Graham M. Keyser, useslasersto selectively dissociate deuteratedhydrofluorocarbonsto form deuteriumfluoride,which can then be separated by physical means. Although the energy consumption for this process is much less than for the Girdler sulfide process, this method is currently uneconomical due to the expense of procuring the necessary hydrofluorocarbons.

As noted, modern commercial heavy water is almost universally referred to, and sold as, deuterium oxide. It is most often sold in various grades of purity, from 98% enrichment to 99.75–99.98% deuterium enrichment (nuclear reactor grade) and occasionally even higher isotopic purity.

Argentina

[edit]

Argentinawas the main producer of heavy water, using an ammonia/hydrogen exchange based plant supplied by Switzerland'sSulzercompany. It was also a major exporter to Canada, Germany, the US and other countries. The heavy water production facility located inArroyitowas the world's largest heavy water production facility. Argentina produced 200 short tons (180 tonnes) of heavy water per year in 2015 using themonothermal ammonia-hydrogen isotopic exchangemethod.[59][60][61][62][63]Since 2017, the Arroyito plant has not been operational.[64]

Soviet Union

[edit]

In October 1939,SovietphysicistsYakov Borisovich Zel'dovichandYulii Borisovich Kharitonconcluded that heavy water and carbon were the only feasible moderators for anatural uraniumreactor, and in August 1940, along withGeorgy Flyorov,submitted a plan to theRussian Academy of Sciencescalculating that 15 tons of heavy water were needed for a reactor. With theSoviet Unionhaving no uranium mines at the time, young Academy workers were sent to Leningrad photographic shops to buy uranium nitrate, but the entire heavy water project was halted in 1941 when German forces invaded duringOperation Barbarossa.

By 1943, Soviet scientists had discovered that all scientific literature relating to heavy water had disappeared from the West, which Flyorov in a letter warned Soviet leaderJoseph Stalinabout,[65]and at which time there was only 2–3 kg of heavy water in the entire country. In late 1943, the Soviet purchasing commission in the U.S. obtained 1 kg of heavy water and a further 100 kg in February 1945, and uponWorld War IIending, theNKVDtook over the project.

In October 1946, as part of theRussian Alsos,theNKVDdeported to theSoviet UnionfromGermanythe German scientists who had worked on heavy water production during the war, includingKarl-Hermann Geib,the inventor of theGirdler sulfide process.[66]These German scientists worked under the supervision ofGermanphysical chemistMax Volmerat the Institute of Physical Chemistry inMoscowwith the plant they constructed producing large quantities of heavy water by 1948.[57][67]

United States

[edit]

During theManhattan Projectthe United States constructed three heavy water production plants as part of theP-9 Projectat Morgantown Ordnance Works, nearMorgantown, West Virginia;at the Wabash River Ordnance Works, near Dana andNewport, Indiana;and at the Alabama Ordnance Works, nearChildersburgandSylacauga, Alabama.Heavy water was also acquired from the Cominco plant inTrail, British Columbia,Canada. TheChicago Pile-3experimental reactor used heavy water as a moderator and went critical in 1944.[68]The three domestic production plants were shut down in 1945 after producing around 81,470lb of product.[69]The Wabash plant resumed heavy water production in 1952.

In 1953, the United States began using heavy water inplutoniumproduction reactors at theSavannah River Site.The first of the fiveheavy water reactorscame online in 1953, and the last was placed in cold shutdown in 1996. The reactors were heavy water reactors so that they could produce both plutonium and tritium for the US nuclear weapons program.

The U.S. developed theGirdler sulfidechemical exchange production process—which was first demonstrated on a large scale at theDana, Indianaplant in 1945 and at the Savannah River Site in 1952.

India

[edit]

India is one of the world's largest producers of heavy water through itsHeavy Water Board.[70]It exports heavy water to countries including the Republic of Korea, China, and the United States.[71][72]

Empire of Japan

[edit]

In the 1930s, it was suspected by the United States and Soviet Union that Austrian chemistFritz Johann Hansgirgbuilt a pilot plant for theEmpire of JapaninJapanese ruled northern Koreato produce heavy water by using a new process he had invented.[73]

Norway

[edit]
Main article:Norwegian heavy water sabotage
"Heavy water" made by Norsk Hydro

In 1934,Norsk Hydrobuilt the first commercial heavy water plant atVemork,Tinn,eventually producing 4 kilograms (8.8 lb) per day.[74]From 1940 and throughoutWorld War II,the plant was underGermancontrol, and theAlliesdecided to destroy the plant and its heavy water to inhibit German development of nuclear weapons. In late 1942, a planned raid calledOperation Freshmanby British airborne troops failed, both gliders crashing. The raiders were killed in the crash or subsequently executed by the Germans.

On the night of 27 February 1943Operation Gunnersidesucceeded. Norwegian commandos and local resistance managed to demolish small, but key parts of the electrolytic cells, dumping the accumulated heavy water down the factory drains.[75]

On 16 November 1943, the Allied air forces dropped more than 400 bombs on the site. The Allied air raid prompted the Nazi government to move all available heavy water to Germany for safekeeping. On 20 February 1944, a Norwegian partisan sank the ferryM/FHydrocarrying heavy water acrossLake Tinn,at the cost of 14 Norwegian civilian lives, and most of the heavy water was presumably lost. A few of the barrels were only half full, hence buoyant, and may have been salvaged and transported to Germany.

Recent investigation of production records at Norsk Hydro and analysis of an intact barrel that was salvaged in 2004 revealed that although the barrels in this shipment contained water ofpH14—indicative of the alkaline electrolytic refinement process—they did not contain high concentrations of D2O.[76]Despite the apparent size of the shipment, the total quantity of pure heavy water was quite small, most barrels only containing 0.5–1% pure heavy water. The Germans would have needed about 5 tons of heavy water to get a nuclear reactor running. The manifest clearly indicated that there was only half a ton of heavy water being transported to Germany.Hydrowas carrying far too little heavy water for one reactor, let alone the 10 or more tons needed to make enough plutonium for a nuclear weapon.[76]TheGerman nuclear weapons programwas much less advanced than the Manhattan Project, and no reactor constructed in Nazi Germany came close to reachingcriticality.No amount of heavy water would have changed that.

Israel admitted running theDimona reactorwith Norwegian heavy water sold to it in 1959. Through re-export using Romania and Germany, India probably also used Norwegian heavy water.[77][78]

Sweden

[edit]

During the second World War, the company Fosfatbolaget inLjungaverk,Sweden, produced 2,300 liters per year of heavy water. The heavy water was then sold both to Germany and to the Manhattan Project for the price of 1,40 SEK per gram of heavy water.[79]

Canada

[edit]

As part of its contribution to the Manhattan Project, Canada built and operated a 1,000 to 1,200 pounds (450 to 540 kg) per month (design capacity) electrolytic heavy water plant atTrail, British Columbia,which started operation in 1943.[80]

TheAtomic Energy of Canada Limited(AECL) design of power reactor requires large quantities of heavy water to act as aneutron moderatorand coolant. AECL ordered two heavy water plants, which were built and operated inAtlantic CanadaatGlace Bay,Nova Scotia(by Deuterium of Canada Limited) andPoint Tupper, Richmond County,Nova Scotia (by Canadian General Electric). These plants proved to have significant design, construction and production problems. The Glace Bay plant reached full production in 1984 after being taken over by AECL in 1971.[81]The Point Tupper plant reached full production in 1974 and AECL purchased the plant in 1975.[82]Design changes from the Point Tupper plant were carried through as AECL built the Bruce Heavy Water Plant (44°11′07″N81°21′42″W/ 44.1854°N 81.3618°W/44.1854; -81.3618(Bruce Heavy Water Plant)),[83]which it later sold toOntario Hydro,to ensure a reliable supply of heavy water for future power plants. The two Nova Scotia plants were shut down in 1985 when their production proved unnecessary.

TheBruce Heavy Water Plant(BHWP) inOntariowas the world's largest heavy water production plant with a capacity of 1600 tonnes per year at its peak (800 tonnes per year per full plant, two fully operational plants at its peak). It used theGirdler sulfide processto produce heavy water, and required 340,000 tonnes of feed water to produce one tonne of heavy water. It was part of a complex that included eightCANDU reactors,which provided heat and power for the heavy water plant. The site was located atDouglas Point/Bruce Nuclear Generating Stationnear Tiverton, Ontario, onLake Huronwhere it had access to the waters of theGreat Lakes.[84]

AECL issued the construction contract in 1969 for the first BHWP unit (BHWP A). Commissioning of BHWP A was done by Ontario Hydro from 1971 through 1973, with the plant entering service on 28 June 1973, and design production capacity being achieved in April 1974. Due to the success of BHWP A and the large amount of heavy water that would be required for the large numbers of upcoming planned CANDU nuclear power plant construction projects, Ontario Hydro commissioned three additional heavy water production plants for theBruce site(BHWP B, C, and D). BHWP B was placed into service in 1979. These first two plants were significantly more efficient than planned, and the number of CANDU construction projects ended up being significantly lower than originally planned, which led to the cancellation of construction on BHWP C & D. In 1984, BHWP A was shut down. By 1993 Ontario Hydro had produced enough heavy water to meet all of its anticipated domestic needs (which were lower than expected due to improved efficiency in the use and recycling of heavy water), so they shut down and demolished half of the capacity of BHWP B. The remaining capacity continued to operate in order to fulfil demand for heavy water exports until it was permanently shut down in 1997, after which the plant was gradually dismantled and the site cleared.[85][86]

AECL is currently researching other more efficient and environmentally benign processes for creating heavy water. This is relevant for CANDU reactors since heavy water represented about 15–20% of the total capital cost of each CANDU plant in the 1970s and 1980s.[86]

Iran

[edit]

Since 1996a plantfor production of heavy water was being constructed at Khondab nearArak.[citation needed]On 26 August 2006, Iranian PresidentAhmadinejadinaugurated the expansion of the country's heavy-water plant. Iran has indicated that the heavy-water production facility will operate in tandem with a 40 MW research reactor that had a scheduled completion date in 2009.[87]Iran produceddeuterated solventsin early 2011 for the first time.[88]The core of the IR-40 is supposed to be re-designed based on thenuclear agreementin July 2015.

Iran is permitted to store only 130tonnes(140short tons) of heavy water.[89]Iran exports excess production, making Iran the world's third largest exporter of heavy water.[90][91]In 2023, Iran sells heavy water; customers have proposed a price over 1,000 dollars per liter.[92]

Pakistan

[edit]

In Pakistan, there are two heavy water production sites that are based inPunjab.Commissioned in 1997–98, theKhushab Nuclear Complexis a central element of Pakistan's stockpile program for production of weapon-grade plutonium, deuterium, and tritium for advanced compact warheads (i.e.thermonuclear weapons). Anotherheavy water facilityfor producing the heavy water is located in Multan, that it sells to nuclear power plants inKarachiandChashma.

In early 1980s, Pakistan succeeded in acquiring a tritium purification and storage plant and deuterium and tritium precursor materials from two former East German firms.[93]Unlike India and Iran, the heavy water produced by Pakistan is not exported nor available for purchase to any nation and is solely used for its weapons complex and energy generation at its local nuclear power plants.

Other countries

[edit]

Romania produced heavy water at the now-decommissionedDrobetaGirdler sulfide plant for domestic and export purposes.[94]France operated a small plant during the 1950s and 1960s.[citation needed]

Applications

[edit]

Nuclear magnetic resonance

[edit]

Deuterium oxide is used innuclear magnetic resonance spectroscopywhen using water as solvent if thenuclideof interest is hydrogen. This is because the signal from light-water (1H2O) solvent molecules would overwhelm the signal from the molecule of interest dissolved in it. Deuterium has a differentmagnetic momentand therefore does not contribute to the1H-NMRsignal at the hydrogen-1 resonance frequency.

For some experiments, it may be desirable to identify the labile hydrogens on a compound, that is hydrogens that can easily exchange away as H+ions on some positions in a molecule. With addition of D2O, sometimes referred to as aD2O shake,[95]labile hydrogens exchange between the compound of interest and the solvent, leading to replacement of those specific1H atoms in the compound with2H. These positions in the molecule then do not appear in the1H-NMR spectrum.

Organic chemistry

[edit]

Deuterium oxide is often used as the source of deuterium for preparing specifically labelledisotopologuesof organic compounds. For example, C-H bonds adjacent to ketonic carbonyl groups can be replaced by C-D bonds, using acid or base catalysis.Trimethylsulfoxonium iodide,made fromdimethyl sulfoxideandmethyl iodidecan be recrystallized from deuterium oxide, and then dissociated to regenerate methyl iodide and dimethyl sulfoxide, both deuterium labelled. In cases where specific double labelling by deuterium and tritium is contemplated, the researcher must be aware that deuterium oxide, depending upon age and origin, can contain some tritium.

Infrared spectroscopy

[edit]

Deuterium oxide is often used instead of water when collectingFTIRspectra of proteins in solution. H2O creates a strong band that overlaps with theamideI region of proteins. The band from D2O is shifted away from the amide I region.

Neutron moderator

[edit]

Heavy water is used in certain types ofnuclear reactors,where it acts as aneutron moderatorto slow down neutrons so that they are more likely to react with thefissileuranium-235than withuranium-238,which captures neutrons without fissioning. The CANDU reactor uses this design. Light water also acts as a moderator, but because light water absorbs moreneutronsthan heavy water, reactors using light water for a reactor moderator must useenriched uraniumrather than natural uranium, otherwisecriticalityis impossible. A significant fraction of outdated power reactors, such as theRBMKreactors in the USSR, were constructed using normal water for cooling butgraphite as a moderator.However, the danger of graphite in power reactors (graphite fires in part led to theChernobyl disaster) has led to the discontinuation of graphite in standard reactor designs.

The breeding and extraction of plutonium can be a relatively rapid and cheap route to building anuclear weapon,as chemical separation of plutonium from fuel is easier thanisotopic separationof U-235 from natural uranium. Among current and pastnuclear weapons states,Israel, India, and North Korea[96]first used plutonium from heavy water moderated reactors burningnatural uranium,while China, South Africa and Pakistan first built weapons usinghighly enriched uranium.

TheNazi nuclear program,operating with more modest means than the contemporary Manhattan Project and hampered by many leading scientists having been driven into exile (many of them ending up working for the Manhattan Project), as well as continuous infighting, wrongly dismissed graphite as a moderator due to not recognizing the effect of impurities. Given thatisotope separationof uranium was deemed too big a hurdle, this left heavy water as a potential moderator. Other problems were the ideological aversion regarding what propaganda dismissed as "Jewish physics"and the mistrust between those who had been enthusiastic Nazis even before 1933 and those who wereMitläuferor trying to keep a low profile. In part due to allied sabotage and commando raids onNorsk Hydro(then the world's largest producer of heavy water) as well as the aforementioned infighting, the German nuclear program never managed to assemble enough uranium and heavy water in one place to achievecriticalitydespite possessing enough of both by the end of the war.

In the U.S., however, the first experimental atomic reactor (1942), as well as theManhattan ProjectHanford production reactors that produced the plutonium for theTrinity testandFat Manbombs, all used pure carbon (graphite) neutron moderators combined with normal water cooling pipes. They functioned with neither enriched uranium nor heavy water. Russian and British plutonium production also used graphite-moderated reactors.

There is no evidence that civilian heavy water power reactors—such as the CANDU orAtuchadesigns—have been used to produce military fissile materials. In nations that do not already possess nuclear weapons, nuclear material at these facilities is underIAEAsafeguards to discourage any diversion.

Due to its potential for use innuclear weaponsprograms, the possession or import/export of large industrial quantities of heavy water are subject to government control in several countries. Suppliers of heavy water and heavy water production technology typically applyIAEA(International Atomic Energy Agency) administered safeguards and material accounting to heavy water. (In Australia, theNuclear Non-Proliferation (Safeguards) Act 1987.) In the U.S. and Canada, non-industrial quantities of heavy water (i.e., in the gram to kg range) are routinely available without special license through chemical supply dealers and commercial companies such as the world's former major producerOntario Hydro.

Neutrino detector

[edit]

TheSudbury Neutrino Observatory(SNO) inSudbury,Ontariouses 1,000 tonnes of heavy water on loan fromAtomic Energy of Canada Limited.Theneutrino detectoris 6,800 feet (2,100 m) underground in a mine, to shield it frommuonsproduced bycosmic rays.SNO was built to answer the question of whether or not electron-typeneutrinosproduced by fusion in theSun(the only type the Sun should be producing directly, according to theory) might be able to turn into other types of neutrinos on the way to Earth. SNO detects theCherenkov radiationin the water from high-energy electrons produced fromelectron-type neutrinosas they undergo charged current (CC) interactions withneutronsindeuterium,turning them into protons and electrons (however, only the electrons are fast enough to produce Cherenkov radiation for detection).

SNO also detects neutrino electron scattering (ES) events, where the neutrino transfers energy to the electron, which then proceeds to generate Cherenkov radiation distinguishable from that produced by CC events. The first of these two reactions is produced only by electron-type neutrinos, while the second can be caused by all of the neutrino flavors. The use of deuterium is critical to the SNO function, because all three "flavours" (types) of neutrinos[97]may be detected in a third type of reaction as well, neutrino-disintegration, in which a neutrino of any type (electron,muon,ortau) scatters from a deuterium nucleus (deuteron), transferring enough energy to break up the loosely bound deuteron into a freeneutronandprotonvia a neutral current (NC) interaction.

This event is detected when the free neutron is absorbed by35Cl−present fromNaCldeliberately dissolved in the heavy water, causing emission of characteristic capture gamma rays. Thus, in this experiment, heavy water not only provides the transparent medium necessary to produce and visualize Cherenkov radiation, but it also provides deuterium to detect exotic mu type (μ) and tau (τ) neutrinos, as well as a non-absorbent moderator medium to preserve free neutrons from this reaction, until they can be absorbed by an easily detected neutron-activated isotope.

Metabolic rate and water turnover testing in physiology and biology

[edit]
Main article:Doubly labeled water test

Heavy water is employed as part of a mixture with H218O for a common and safe test of mean metabolic rate in humans and animals undergoing their normal activities.The elimination rate of deuterium alone is a measure of body water turnover. This is highly variable between individuals and depends on environmental conditions as well as subject size, sex, age and physical activity.[98]

Tritium production

[edit]
See also:Tritium § Deuterium

Tritiumis the active substance inself-powered lightingand controlled nuclear fusion, its other uses includingautoradiographyandradioactive labeling.It is also used innuclear weapon designforboosted fission weaponsandinitiators.Tritium undergoesbeta decayintohelium-3,which is a stable, but rare, isotope of helium that is itself highly sought after. Some tritium is created inheavy water moderated reactorswhen deuterium captures a neutron. This reaction has a smallcross-section(probability of a single neutron-capture event) and produces only small amounts of tritium, although enough to justify cleaning tritium from the moderator every few years to reduce the environmental risk of tritium escape. Given that helium-3 is aneutron poisonwith orders of magnitude higher capture cross section than any component of heavy or tritiated water, its accumulation in a heavy water neutron moderator ortargetfor tritium production must be kept to a minimum.

Producing a lot of tritium in this way would require reactors with very high neutron fluxes, or with a very high proportion of heavy water tonuclear fueland very lowneutron absorptionby other reactor material. The tritium would then have to be recovered byisotope separationfrom a much larger quantity of deuterium, unlike production fromlithium-6(the present method), where only chemical separation is needed.

Deuterium's absorption cross section forthermal neutronsis 0.52 millibarn(5.2 × 10−32m2;1 barn = 10−28m2), while those ofoxygen-16andoxygen-17are 0.19 and 0.24 millibarn, respectively.17O makes up 0.038% of naturaloxygen,making the overall cross section 0.28 millibarns. Therefore, in D2O with natural oxygen, 21% ofneutron capturesare on oxygen, rising higher as17O builds up from neutron capture on16O. Also,17O may emit anAlpha particleon neutron capture, producing radioactivecarbon-14.

See also

[edit]

References

[edit]
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