EGLN3
Appearance
Egl nine homolog 3is aproteinthat in humans is encoded by theEGLN3gene.[5]ELGN3 is a member of the superfamily ofAlpha -ketoglutarate-dependent hydroxylases,which are non-haem iron-containing proteins.
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000129521–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000035105–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Entrez Gene: EGLN3 egl nine homolog 3 (C. elegans)".
Further reading
[edit]- Semenza GL (October 2001)."HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus".Cell.107(1): 1–3.doi:10.1016/S0092-8674(01)00518-9.PMID11595178.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
- Taylor MS (September 2001). "Characterization and comparative analysis of the EGLN gene family".Gene.275(1): 125–32.doi:10.1016/S0378-1119(01)00633-3.PMID11574160.
- Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ (October 2001)."C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation".Cell.107(1): 43–54.doi:10.1016/S0092-8674(01)00507-4.PMID11595184.
- Bruick RK, McKnight SL (November 2001). "A conserved family of prolyl-4-hydroxylases that modify HIF".Science.294(5545): 1337–40.Bibcode:2001Sci...294.1337B.doi:10.1126/science.1066373.PMID11598268.S2CID9695199.
- Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hütter J, Schramm M, Flamme I (August 2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors".Biochemical and Biophysical Research Communications.296(2): 343–9.doi:10.1016/S0006-291X(02)00862-8.PMID12163023.
- Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J (April 2003). "Intracellular localisation of human HIF-1 Alpha hydroxylases: implications for oxygen sensing".Journal of Cell Science.116(Pt 7): 1319–26.doi:10.1242/jcs.00318.PMID12615973.S2CID13698068.
- Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR (April 2003). "Differential regulation of HIF-1 Alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells".Biochemical and Biophysical Research Communications.303(3): 947–53.doi:10.1016/S0006-291X(03)00453-4.PMID12670503.
- Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC (June 2004)."Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors".Journal of Cellular Biochemistry.92(3): 491–501.doi:10.1002/jcb.20067.PMID15156561.S2CID24455956.
- Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM (September 2004)."Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor".The Journal of Biological Chemistry.279(37): 38458–65.doi:10.1074/jbc.M406026200.PMID15247232.
- Masson N, Appelhoff RJ, Tuckerman JR, Tian YM, Demol H, Puype M, Vandekerckhove J, Ratcliffe PJ, Pugh CW (July 2004)."The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin".FEBS Letters.570(1–3): 166–70.doi:10.1016/j.febslet.2004.06.040.PMID15251459.
- Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL (February 2005)."OS-9 interacts with hypoxia-inducible factor 1 Alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1 Alpha".Molecular Cell.17(4): 503–12.doi:10.1016/j.molcel.2005.01.011.PMID15721254.
- Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S (August 2005)."Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer".Cancer Cell.8(2): 155–67.doi:10.1016/j.ccr.2005.06.015.PMID16098468.
- Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (March 2006)."The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)".The Journal of Biological Chemistry.281(13): 8645–55.doi:10.1074/jbc.M513751200.PMID16407229.
- Nakayama K, Gazdoiu S, Abraham R, Pan ZQ, Ronai Z (January 2007)."Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2".The Biochemical Journal.401(1): 217–26.doi:10.1042/BJ20061135.PMC1698661.PMID16958618.