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Edvard Moser

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Edvard Moser
Edvard Moser in 2015
Born
Edvard Ingjald Moser

Ålesund,Norway
Alma materUniversity of Oslo
Known forGrid cells,place cells,border cells,neurons
SpouseMay-Britt Moser(1985–2016)
AwardsLouis-Jeantet Prize for Medicine(2011)
Foreign Associate of the National Academy of Sciences(2014)
Nobel Prize in Physiology or Medicine(2014)
Scientific career
FieldsNeuroscience
InstitutionsNorwegian University of Science and Technology
University of Edinburgh
Doctoral studentsMarianne Fyhn

Edvard Ingjald Moser(pronounced[ˈɛ̀dvɑɖˈmoːsər]) is a Norwegian psychologist and neuroscientist, who as of May 2024is a professor at theNorwegian University of Science and Technology(NTNU) inTrondheim.

He shared theNobel Prize in Physiology or Medicinein 2014 with long-term collaborator and then-wifeMay-Britt Moser,and previous mentorJohn O'Keefefor their work identifying the brain's positioning system. The two main components of the brain's GPS are grid cells andplace cells,a specialized type of neuron that respond to specific locations in space. Together with May-Britt Moser he established theMoser research environment.

In 1996 he was appointed as associate professor inbiological psychologyat the Department of Psychology at theNorwegian University of Science and Technology(NTNU); he was promoted to professor of neuroscience in 1998. In 2002, his research group was given the status of a separate "centre of excellence". Edvard Moser has led a succession of research groups and centres, collectively known as theMoser research environment.

Early life and education[edit]

Moser was born inÅlesundto German parents Eduard Paul Moser (1928–2013) and Ingeborg Annamarie Herholz (1931–). His parents had grown up inKronberg im Taunus,a suburb ofFrankfurt,where Moser's grandfather Eduard Moser had been Lutheran parish priest. Moser's father trained as apipe organbuilder and emigrated to Norway together with his friend Jakob Pieroth in 1953 when they were offered employment at a pipe organ workshop atHaramsøy.They later established their own workshop and built many church pipe organs in Norway.[1][2]The Moser family originally was fromNassau;Moseris a South German topographic name for someone who lived near aswampormire(South GermanMoos).[3]Edvard Moser grew up atHareidand inÅlesund.[4][5][6]He was raised in a conservativeChristianfamily.[7]

Edvard Moser marriedMay-Britt Moserin 1985 when they were both students.[8]They announced that they are divorcing in 2016.[9]

His sister is the sociologistIngunn Moser,known as the founding rector ofVID University.[10]

Moser was awarded the cand.psychol. degree in psychology at theDepartment of Psychologyat theUniversity of Osloin 1990. He was then employed as a research fellow at the Faculty of Medicine, where he obtained hisdr.philos.doctoral research degree in the field ofneurophysiologyin 1995.[11]He also has studied mathematics and statistics.[12]Early in his career, he worked under the supervision ofPer Andersen.

Moser went on to undertake postdoctoral training withRichard G. Morrisat the Centre for Neuroscience,University of Edinburgh,from 1995 to 1997,[13]and was a visiting postdoctoral fellow at the laboratory ofJohn O'Keefeat theUniversity College, Londonfor two months.

Career[edit]

Moser returned to Norway in 1996 to be appointed associate professor in biological psychology at the Department of Psychology at the Norwegian University of Science and Technology (NTNU) in Trondheim. He was promoted to full professor of neuroscience in 1998. Moser is also head of department of the NTNU Institute for Systems Neuroscience.[citation needed]

Moser is founding director/co-director of threeResearch Council-funded centres of excellence:[14]

  • Centre for the Biology of Memory (2002-2012)
  • Centre for Neural Computation (2012-2022)
  • Centre for Algorithms in the Cortex (2023-2033)

In 2007 the centres became aKavli Institute for Systems Neuroscience,with Moser as director.[14]

as of May 2024is a professor at theNorwegian University of Science and Technology(NTNU) inTrondheim.[14]

Research[edit]

In 2005, he and his then-wifeMay-Britt Moserdiscoveredgrid cells[15]in the brain's medialentorhinal cortex.Grid cells are specialized neurons that provide the brain with a coordinate system and a metric for space. In 2018, he discovered a neural network that expresses a person's sense of time in experiences and memories located in the brain's lateralentorhinal cortex.[16]

He shared theNobel Prize in Physiology or Medicinein 2014 with long-term collaborator and then-wifeMay-Britt Moser,and previous mentorJohn O'Keefefor their work identifying the brain's positioning system. The two main components of the brain's GPS are; grid cells andplace cells,[17]a specialized type of neuron that respond to specific locations in space.[18][19]Together with May-Britt Moser he established theMoser research environment,which they lead.

Other activities[edit]

He is a member of theRoyal Norwegian Society of Sciences and Letters,[20]Norwegian Academy of Science and Letters,[21]theAmerican Philosophical Society,[22]and theNorwegian Academy of Technological Sciences.[23]

In 2015 he became an external scientific member of theMax Planck Institute of Neurobiology,with which he has collaborated over several years.[24]

He is also anhonorary professorat the Centre for Cognitive and Neural Systems at theUniversity of Edinburgh Medical School.[13]

Moser has been a member of the board of reviewing editors in science since 2004 and he has been reviewing editor forJournal of Neurosciencesince 2005. He chaired the programme committee of the European Neuroscience meeting (FENS Forum) in 2006.[citation needed]

Honours[edit]

Selected publications[edit]

  • Moser, E.I., Mathiesen, I. & Andersen, P. (1993). Association between brain temperature and dentate field potentials in exploring and swimming rats.Science,259, 1324–1326.
  • Brun, V.H., Otnæss, M.K., Molden, S., Steffenach, H.-A., Witter, M.P., Moser, M.-B., Moser, E.I. (2002). Place cells and place representation maintained by direct entorhinal-hippocampal circuitry.Science,296, 2089–2284.
  • Fyhn, M., Molden, S., Witter, M.P., Moser, E.I. and Moser, M.-B. (2004). Spatial representation in the entorhinal cortex.Science,305, 1258–1264Archived17 February 2012 at theWayback Machine.
  • Leutgeb, S., Leutgeb, J.K., Treves, A., Moser, M.-B. and Moser, E.I. (2004). Distinct ensemble codes in hippocampal areas CA3 and CA1.Science,305, 1295–1298.
  • Leutgeb, S., Leutgeb, J.K., Barnes, C.A., Moser, E.I., McNaughton, B.L., and Moser, M.-B (2005). Independent codes for spatial and episodic memory in the hippocampus.Science,309, 619–623Archived17 February 2012 at theWayback Machine.
  • Hafting, T., Fyhn, M., Molden, S., Moser, M.-B., and Moser, E.I. (2005). Microstructure of a spatial map in the entorhinal cortex.Nature,436, 801–806.
  • Colgin, L.L, and Moser, E.I. (2006). Rewinding the memory record.Nature,440, 615–617.
  • Sargolini, F., Fyhn, M., Hafting, T., McNaughton, B.L., Witter, M.P., Moser, M.-B., and Moser, E.I. (2006). Conjunctive representation of position, direction and velocity in entorhinal cortex.Science,312, 754–758.
  • Leutgeb, J.K., Leutgeb, S., Moser, M.-B., and Moser, E.I. (2007). Pattern separation in dentate gyrus and CA3 of the hippocampus.Science,315, 961–966.
  • Fyhn, M., Hafting, T., Treves, A., Moser, M.-B. and Moser, E.I. (2007). Hippocampal remapping and grid realignment in entorhinal cortex.Nature,446, 190–194.
  • Hafting, T., Fyhn, M., Bonnevie, T., Moser, M.-B. and Moser, E.I. (2008). Hippocampus-independent phase precession in entorhinal grid cells.Nature453, 1248–1252.
  • Kjelstrup, K.B., Solstad, T., Brun, V.H., Hafting, T., Leutgeb, S., Witter, M.P., Moser, E.I. and Moser, M.-B. (2008). Finite scales of spatial representation in the hippocampus.Science321, 140–143.
  • Solstad, T., Boccara, C.N., Kropff, E., Moser, M.-B. and Moser, E.I. (2008). Representation of geometric borders in the entorhinal cortex.Science,322, 1865–1868.
  • Moser, E.I., Moser, M-B. (2011). Crystals of the brain. EMBO Mol. Med. 3, 1–4.
  • Moser, E.I., Moser, M-B. (2011). Seeing into the future. Nature, 469, 303–4
  • Jezek, K., Henriksen, EJ., Treves, A., Moser, E.I. and Moser, M-B. (2011). Theta-paced flickering between place-cell maps in the hippocampus. Nature, 478, 246–249.
  • Giocomo, LM., Moser, E.I., Moser, M-B. (2011) Grid cells use HCN1 channels for spatial scaling. Cell, 147, 1159–1170.
  • Igarashi, KM., Lu L., Colgin LL., Moser M-B., Moser EI. (2014) Coordination of entorhinal-hippocampal ensemble activity during associative learning.Nature510, 143–7.

References[edit]

  1. ^"Orgelskatt på fabrikkloft,"Sunnmørsposten21 February 1994 p. 7
  2. ^"Ratten mit Hütchen",FAZ,7 October 2014
  3. ^Jana Kötter, "Ein Hoch auf die Heimat",Taunus-Zeitung,16 October 2014
  4. ^Inger Otterlei (9 April 2011)."Nobelprisen neste?".smp.no.
  5. ^Fridgeir Walderhaug (6 October 2014)."Flagget for May-Britt og Edvard".Dagbladet.no.
  6. ^Frankfurter Allgemeine Zeitung GmbH (7 October 2014)."Zu Besuch bei Nobelpreisträgerin May-Britt Moser".FAZ.NET.
  7. ^Edvard Moser – Biographical
  8. ^James Gorman (30 April 2013)."A Sense of Where You Are".The New York Times.
  9. ^Magnus Braaten (25 January 2016)."Nobelpris-paret Moser skilles".VG.
  10. ^– Jeg er stolt og glad
  11. ^Moser, M-B. (1995).Field potential changes in the dentate gyrus during spatial learning in the rat.Thesis for the degree of Dr. Philos., University of Oslo (defended on 9 December 1995).
  12. ^FENS Office (23 May 2013)."Moser, Edvard I."FENS.org.Archived fromthe originalon 7 October 2014.Retrieved7 October2014.
  13. ^ab"Nobels for research pioneers".University of Edinburgh.Retrieved9 October2014.
  14. ^abc"Edvard Ingjald Moser".NTNU(in Norwegian Bokmål).Retrieved16 May2024.
  15. ^Hafting, T; Fyhn, M; Molden, S; Moser, MB; Moser, EI (2005)."Microstructure of a spatial map in the entorhinal cortex".Nature.436(7052): 801–6.Bibcode:2005Natur.436..801H.doi:10.1038/nature03721.PMID15965463.S2CID4405184.
  16. ^Tsao, A; Sugar, J; Lu, L; Wang, C; Knierim, JJ; Moser, MB; et al. (2018)."Integrating time from experience in the lateral entorhinal cortex".Nature.561(7721): 57–62.Bibcode:2018Natur.561...57T.doi:10.1038/s41586-018-0459-6.hdl:11250/2578403.PMID30158699.S2CID52116115.
  17. ^O'Keefe J, Dostrovsky J (1971)."The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat".Brain Res.34(1): 171–5.doi:10.1016/0006-8993(71)90358-1.PMID5124915.
  18. ^"The Nobel Prize in Physiology or Medicine 2014".nobelprize.org.Retrieved7 February2017.
  19. ^Fenton, André A.(1 June 2015). "Coordinating with the" Inner GPS "".Hippocampus.25(6): 763–769.doi:10.1002/hipo.22451.ISSN1098-1063.PMID25800714.S2CID34277620.
  20. ^"Gruppe IV Generell biologi"(in Norwegian).Royal Norwegian Society of Sciences and Letters.Archived fromthe originalon 10 December 2014.Retrieved6 October2014.
  21. ^"Gruppe 7: Medisinske fag"(in Norwegian).Norwegian Academy of Science and Letters.Archived fromthe originalon 15 September 2018.Retrieved28 October2009.
  22. ^"APS Member History".search.amphilsoc.org.Retrieved1 March2021.
  23. ^"Medlemmer: MOSER, Edvard"(in Norwegian).Norwegian Academy of Technological Sciences.Retrieved11 May2013.
  24. ^"Nobel laureate Moser becomes external member of the Max Planck Institute of Neurobiology".Archived fromthe originalon 19 June 2021.Retrieved2 November2018.
  25. ^Mangler informasjonskapsel."The Anders Jahre Senior Medical Prize".uio.no.Archived fromthe originalon 27 March 2020.Retrieved11 September2012.
  26. ^13th Perl-UNC Neuroscience Prize RecipientsArchived2 December 2013 at theWayback MachineUNC Neuroscience Center. Retrieved 23 September 2013
  27. ^"The Louisa Gross Horwitz Prize".columbia.edu.14 June 2018.
  28. ^Award CeremoniesAmphilsoc.org. Retrieved 21 March 2014
  29. ^Svein Inge Meland (30 April 2014)Unik ære til Moserne(in Norwegian)Adressa.Retrieved 30 April 2014.
  30. ^"Archived copy"(PDF).Archived fromthe original(PDF)on 17 July 2018.Retrieved13 June2017.{{cite web}}:CS1 maint: archived copy as title (link)
  31. ^"Utnevnelser til St. Olavs Orden".kongehuset.no(in Norwegian).Retrieved21 February2018.

External links[edit]

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