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Ensitrelvir

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Ensitrelvir
Clinical data
Trade namesXocova
Other namesS-217622
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Identifiers
  • 1-(2,4,5-Trifluorobenzyl)-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-(6E)-6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]-1,3,5-triazinane-2,4-dione
CAS Number
PubChemCID
UNII
KEGG
Chemical and physical data
FormulaC22H17ClF3N9O2
Molar mass531.88g·mol−1
3D model (JSmol)
  • Cn1cnc(CN2C(=O)N(Cc3cc(F)c(F)cc3F)C(=N\c3cc4cn(C)nc4cc3Cl)\NC2=O)n1
  • InChI=1S/C22H17ClF3N9O2/c1-32-7-12-4-18(13(23)5-17(12)30-32)28-20-29-21(36)35(9-19-27-10-33(2)31-19)22(37)34(20)8-11-3-15(25)16(26)6-14(11)24/h3-7,10H,8-9H2,1-2H3,(H,28,29,36)
  • Key:QMPBBNUOBOFBFS-UHFFFAOYSA-N
Xocova in a Japanese blister pack

Ensitrelvir,sold under the brand nameXocovais anantiviral medicationused as a treatment forCOVID-19.[2][3][4][5]It was developed byShionogiin partnership withHokkaido Universityand acts as an orally active3C-likeprotease inhibitor.[6][7]It is taken by mouth.[8][9][10]

The most commonadverse eventsinclude transient decreases inhigh-density lipoproteinand increasesblood triglycerides.[8]

Medical uses

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Ensitrelvir isindicatedfor the treatment ofCOVID-19.[8]

History

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As of 2022,ensitrelvir had reached Phase IIIclinical trials.[11]The Japanese government is reportedly considering allowing Shionogi permission to apply for approval for medical use before the final steps of trials are completed, potentially speeding up the release for sale. This conditional early approval system has previously been used in Japan to accelerate the progression to market of other antiviral drugs targeting COVID-19, includingremdesivirandmolnupiravir.[12]In a study of 428 patients, viral load was reduced, but symptoms were not significantly reduced.[13]

In February 2022, the company sought emergency approval from regulators in Japan.[3][13]

Shionogi announced they had reached a preliminary agreement to supply 1million doses to the Japanese government once the drug is approved. The CEO said they could have capacity to make 10million doses a year.[14]

Ensitrelvir may be effective in treatingsmell and taste lossfrom COVID-19 infection. In a 2023 study, the drug was associated with a 39% reduction in these symptoms.[15]

Society and culture

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Ensitrelvir was approved for emergency use in Japan in November 2022,[8][3][4]before gaining full approval in March 2024.[1]It was approved in Singapore in November 2023.[16]

In April 2023, ensitrelvir was given a "Fast Track"designation from the USFood and Drug Administration.[17]

Names

[edit]

Ensitrelvir is theInternational Nonproprietary Name.[18]

Research

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Ensitrelvir is being studied for its potential use aspost-exposure prophylaxis(PEP) after SARS-CoV-2 exposure.[19][20]The SCORPIO-PEP trial is a global Phase 3 trial that will evaluate the safety and efficacy of the drug in preventing symptomatic SARS-CoV-2 infection in household contacts of people who tested positive for COVID-19.[20][21][22][23]

An April 2024 pre-clinical study in a mouse model investigating ensitrelvir demonstrated its potential use as apre-exposure prophylactic(PrEP) against developing COVID-19. When administered 24 hours before viral exposure, a single dose of ensitrelvir significantly increased survival rates, inhibited weight loss, and suppressed viral replication in aged mice.[24]

A retrospective study conducted between November 2022 and July 2023 using a large Japanese health insurance database suggested that ensitrelvir may be effective in reducing hospitalization risk in outpatients at high risk for severe COVID-19. The study found a significantly lower risk of hospitalization and a reduced need for respiratory monitoring and oxygen therapy in the ensitrelvir group compared to the control group.[25]

References

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  1. ^ab"Japan health ministry approves Shionogi's COVID drug Xocova".NHK WORLD.5 March 2024.Retrieved6 March2024.
  2. ^McCarthy MW (December 2022). "Ensitrelvir as a potential treatment for COVID-19".Expert Opin Pharmacother.23(18): 1995–1998.doi:10.1080/14656566.2022.2146493.PMID36350029.S2CID253418404.
  3. ^abcFujikawa M (22 November 2022)."Japan Approves First Homegrown Covid-19 Antiviral Pill".The Wall Street Journal.Retrieved28 November2022.
  4. ^ab"Shionogi's Covid antiviral lands first approval in Japan's new emergency approval pathway".Endpoints News.22 November 2022.Retrieved28 November2022.
  5. ^"Xocova: Powerful New Japanese Pill for Coronavirus Treatment".BioPharma Media.February 2022.
  6. ^Unoh Y, Uehara S, Nakahara K, Nobori H, Yamatsu Y, Yamamoto S, et al. (May 2022)."Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19".Journal of Medicinal Chemistry.65(9): 6499–6512.doi:10.1021/acs.jmedchem.2c00117.PMC8982737.PMID35352927.
  7. ^"Shionogi presents positive Ph II/III results for COVID-19 antiviral S-217622".thepharmaletter.31 January 2022.
  8. ^abcd"Xocova (Ensitrelvir Fumaric Acid) Tablets 125mg Approved in Japan for the Treatment of SARS-CoV-2 Infection, under the Emergency Regulatory Approval System".Shionogi(Press release). 22 November 2022.Retrieved28 November2022.
  9. ^"Shionogi's new COVID pill appears to ease omicron symptoms".Nikkei Asia.21 December 2021.
  10. ^Uraki R, Kiso M, Iida S, Imai M, Takashita E, Kuroda M, et al. (IASO study team) (May 2022)."Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2".Nature.607(7917): 119–127.Bibcode:2022Natur.607..119U.doi:10.1038/s41586-022-04856-1.PMC10579982.PMID35576972.S2CID248833104.
  11. ^Tyndall JD (May 2022). "S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARS-CoV-2".Journal of Medicinal Chemistry.65(9): 6496–6498.doi:10.1021/acs.jmedchem.2c00624.PMID35507419.S2CID248513467.
  12. ^"Japan to consider early approval for Shionogi COVID-19 pill".Japan Times.8 February 2022.
  13. ^ab"Japan's Shionogi seeks approval for COVID-19 pill".Reuters.25 February 2022.
  14. ^"Japan's Shionogi signs government supply pact for pill to fight COVID".Reuters. 25 March 2022.
  15. ^Lenharo M (17 October 2023)."New pill helps COVID smell and taste loss fade quickly".Nature.doi:10.1038/d41586-023-03244-7.PMID37853192.S2CID264303912.
  16. ^"Shionogi reports data from Phase III portion of Covid-19 drug trial".Clinical Trials Arena.12 February 2024.Retrieved6 March2024.
  17. ^Ducharme J (25 January 2024)."When Will We Get New COVID-19 Drugs?".Time.Retrieved6 March2024.
  18. ^World Health Organization(2022). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 88".WHO Drug Information.36(3): 89.hdl:10665/363551.
  19. ^Cosdon N (31 March 2023)."Ensitrelvir: A COVID-19 Antiviral That Remains Effective Against New Variants".ContagionLive.Retrieved28 October2023.
  20. ^ab"Shionogi presses on with Xocova research following Japanese approval".The Pharma Letter.16 February 2023.Retrieved28 October2023.
  21. ^"Studies Currently Enrolling".University of Kansas Medical Center.Archived fromthe originalon 28 October 2023.Retrieved28 October2023.SCORPIO-PEP is a 28-day study to assess the prevention of COVID-19 infection in those who have been exposed through household contact.
  22. ^"Shionogi Enrolls the First Participant in Japan in its Global Phase 3 Trial of Ensitrelvir for the Prevention of Symptomatic SARS-CoV-2 Infection"(Press release). Osaka, Japan. 9 June 2023.Retrieved28 October2023.
  23. ^"The SCORPIO-PEP Study".SCORPIO-PEP.Shionogi Inc.Archivedfrom the original on 11 May 2024.Retrieved4 July2024.
  24. ^Nobori H, Baba K, Kuroda T, Baba K, Matsumoto K, Yoshida S, et al. (April 2024)."Prophylactic effect of ensitrelvir in mice infected with SARS-CoV-2".Antiviral Research.224:105852.doi:10.1016/j.antiviral.2024.105852.PMID38428748.
  25. ^Takazono T, Fujita S, Komeda T, Miyazawa S, Yoshida Y, Kitanishi Y, et al. (June 2024)."Real-World Effectiveness of Ensitrelvir in Reducing Severe Outcomes in Outpatients at High Risk for COVID-19".Infectious Diseases and Therapy.13(8): 1821–1833.doi:10.1007/s40121-024-01010-4.PMC11266320.PMID38941067.