Flutrimazole

Flutrimazole
Clinical data
AHFS/Drugs	International Drug Names
ATC code	D01AC16(WHO)G01AF18(WHO);
Identifiers
	IUPAC name (RS)-1-[(2-Fluorophenyl)(4-fluorophenyl)benzyl]-1H-imidazole;
CAS Number	119006-77-8;
PubChemCID	3401;
ChemSpider	3284;
UNII	776S0UP252;
KEGG	D07193;
ChEBI	CHEBI:82864;
ChEMBL	ChEMBL2107430;
CompTox Dashboard(EPA)	DTXSID30869622;
ECHA InfoCard	100.170.770
Chemical and physical data
Formula	C22H16F2N2
Molar mass	346.381g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES Fc1ccc(cc1)C(c2c(F)cccc2)(c3ccccc3)n4ccnc4;
	InChI InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H; Key:QHMWCHQXCUNUAK-UHFFFAOYSA-N;
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Flutrimazoleis a wide-spectrumantifungaldrug. It is used for the topical treatment of superficialmycosesof theskin.Flutrimazole is animidazolederivative. Its antifungal activity has been demonstrated inin vivoandin vitrostudies to be comparable to that ofclotrimazoleand higher thanbifonazole.^[1]

Mechanism of action

It interferes with the synthesis ofergosterolby inhibiting the activity of theenzyme lanosterol 14 α-demethylase.^{[citation needed]}

References

The Merck Index, 12th Edition. 4247

^Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J (1995). "Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group".Dermatology.190(4): 295–300.doi:10.1159/000246720.PMID 7655109.

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[1] Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J (1995). "Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group".Dermatology.190(4): 295–300.doi:10.1159/000246720.PMID 7655109.

[1]

Mechanism of action

See also

References