Flutrimazole
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ECHA InfoCard | 100.170.770 |
Chemical and physical data | |
Formula | C22H16F2N2 |
Molar mass | 346.381g·mol−1 |
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Chirality | Racemic mixture |
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Flutrimazoleis a wide-spectrumantifungaldrug. It is used for the topical treatment of superficialmycosesof theskin.Flutrimazole is animidazolederivative. Its antifungal activity has been demonstrated inin vivoandin vitrostudies to be comparable to that ofclotrimazoleand higher thanbifonazole.[1]
Mechanism of action
[edit]It interferes with the synthesis ofergosterolby inhibiting the activity of theenzymelanosterol 14 α-demethylase.[citation needed]
See also
[edit]References
[edit]The Merck Index, 12th Edition. 4247
- ^Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J (1995). "Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group".Dermatology.190(4): 295–300.doi:10.1159/000246720.PMID7655109.