GNG5

GNG5
Identifiers
Aliases	GNG5,G protein subunit gamma 5
External IDs	OMIM:600874;MGI:3783217;HomoloGene:3861;GeneCards:GNG5;OMA:GNG5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p22.3 Start 84,498,323bp End 84,506,581bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in mucosa of transverse colon left ventricle right auricle apex of heart muscle of thigh right lung ventricular zone upper lobe of left lung olfactory zone of nasal mucosa granulocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein binding GTPase activity signal transducer activity G-protein beta-subunit binding Cellular component extracellular exosome mitochondrion membrane heterotrimeric G-protein complex plasma membrane G-protein beta/gamma-subunit complex Biological process positive regulation of neural precursor cell proliferation positive regulation of secondary heart field cardioblast proliferation cellular response to glucagon stimulus signal transduction G protein-coupled receptor signaling pathway Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 2787 100043507 Ensembl ENSG00000174021 n/a UniProt P63218 Q80SZ7 RefSeq (mRNA) NM_005274 n/a RefSeq (protein) NP_005265 NP_034448 Location (UCSC) Chr 1: 84.5 – 84.51 Mb n/a PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5is aproteinthat in humans is encoded by theGNG5gene.

Further reading

• Fisher KJ, Aronson NN (1992)."Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)".Mol. Cell. Biol.12(4): 1585–91.doi:10.1128/mcb.12.4.1585.PMC369601.PMID1549114.
• Yan K, Kalyanaraman V, Gautam N (1996)."Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families".J. Biol. Chem.271(12): 7141–6.doi:10.1074/jbc.271.12.7141.PMID8636150.
• Mao M, Fu G, Wu JS, et al. (1998)."Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning".Proc. Natl. Acad. Sci. U.S.A.95(14): 8175–80.Bibcode:1998PNAS...95.8175M.doi:10.1073/pnas.95.14.8175.PMC20949.PMID9653160.
• Liu B, Aronson NN (1998). "Structure of human G protein G gamma 5 gene GNG5".Biochem. Biophys. Res. Commun.251(1): 88–94.doi:10.1006/bbrc.1998.9439.PMID9790912.
• Zhang QH, Ye M, Wu XY, et al. (2001)."Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells".Genome Res.10(10): 1546–60.doi:10.1101/gr.140200.PMC310934.PMID11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Cuello F, Schulze RA, Heemeyer F, et al. (2003)."Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta".J. Biol. Chem.278(9): 7220–6.doi:10.1074/jbc.M210304200.PMID12486123.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".Nat. Biotechnol.21(5): 566–9.doi:10.1038/nbt810.PMID12665801.S2CID23783563.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006)."The DNA sequence and biological annotation of human chromosome 1".Nature.441(7091): 315–21.Bibcode:2006Natur.441..315G.doi:10.1038/nature04727.PMID16710414.