GPR12

GPR12
Identifiers
Aliases	GPR12,GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM:600752;MGI:101909;HomoloGene:3868;GeneCards:GPR12;OMA:GPR12 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	26,760,786bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,522,049bp
RNA expressionpattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; putamen; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; Region I of hippocampus proper; ; dorsal striatum; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; phosphatidylcholine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; cellular calcium ion homeostasis; signal transduction;
	Sources:Amigo/QuickGO
Orthologs
	2835
	14738
	ENSG00000132975
	ENSMUSG00000041468
	P47775
	P35412
	NM_005288
NM_001010941; NM_008151; NM_001359055; NM_001359056; NM_001359057;
	NM_001359058
	NP_005279
NP_001010941; NP_032177; NP_001345984; NP_001345985; NP_001345986;
	NP_001345987
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 12is aproteinthat in humans is encoded by theGPR12gene.^[5]^[6]^[7]

The gene product of GPR12 is anorphan receptor,meaning that its endogenousligandis currently unknown. Gene disruption of GPR12 in mice results indyslipidemiaand obesity.^[8]

Ligands

Inverse agonists

Cannabidiol^[9]

Evolution

Paralogues

Source:^[10]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000132975–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000041468–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993)."Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system".FEBS Letters.336(2): 317–22.doi:10.1016/0014-5793(93)80828-I.PMID 8262253.S2CID 31345248.
^Song ZH, Modi W, Bonner TI (July 1995)."Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors".Genomics.28(2): 347–9.doi:10.1006/geno.1995.1154.PMID 8530049.
^"Entrez Gene: GPR12 G protein-coupled receptor 12".
^Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice".Biochemical and Biophysical Research Communications.348(2): 359–66.doi:10.1016/j.bbrc.2006.07.090.PMID 16887097.
^Brown KJ, Laun AS, Song ZH (November 2017)."Cannabidiol, a novel inverse agonist for GPR12".Biochemical and Biophysical Research Communications.493(1): 451–454.doi:10.1016/j.bbrc.2017.09.001.PMC5849771.PMID 28888984.
^"GeneCards®: The Human Gene Database".

Ligands

Evolution

Paralogues

References

Further reading