GRB10
Growth factor receptor-bound protein 10also known asinsulin receptor-binding protein Grb-IRis aproteinthat in humans is encoded by theGRB10gene.[5][6][7][8]
Function
[edit]The product of this gene belongs to a small family ofadaptor proteinsthat are known to interact with a number ofreceptor tyrosine kinasesand signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts withinsulin receptorsand insulin-like growth-factor receptors (e.g.,IGF1RandIGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
Animal studies
[edit]Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.[9]
Interactions
[edit]GRB10 has been shown tointeractwith
- Abl gene,[10][11]
- BCR gene,[10]
- C-Raf,[12][13]
- c-Kit,[14]
- Insulin receptor,[11][15][16][17]>[18]
- Insulin-like growth factor 1 receptor,[18][19][20][21]
- MAP2K1,[13]and
- RET proto-oncogene.[22]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000106070–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000020176–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ab"Entrez Gene: GRB10 growth factor receptor-bound protein 10".
- ^Jerome CA, Scherer SW, Tsui LC, Gietz RD, Triggs-Raine B (February 1997). "Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12".Genomics.40(1): 215–6.doi:10.1006/geno.1996.4535.PMID9070953.
- ^Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J (November 1997)."Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma".J. Biol. Chem.272(46): 29104–12.doi:10.1074/jbc.272.46.29104.PMID9360986.
- ^Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE (August 2009)."Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression".Hum. Mol. Genet.18(16): 3066–74.doi:10.1093/hmg/ddp248.PMID19487367.
- ^Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A (2011)."Distinct physiological and behavioural functions for parental alleles of imprinted Grb10".Nature.469(7331): 534–538.Bibcode:2011Natur.469..534G.doi:10.1038/nature09651.PMC3031026.PMID21270893.*Lay summary in:Bhanoo SN (January 27, 2011)."Altering a Mouse Gene Turns Up Aggression, Study Says".New York Times.
- ^abBai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998)."The SH2-containing adapter protein GRB10 interacts with BCR-ABL".Oncogene.17(8): 941–8.doi:10.1038/sj.onc.1202024.PMID9747873.
- ^abFrantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (January 1997)."Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains".J Biol Chem.272(5): 2659–67.doi:10.1074/jbc.272.5.2659.PMID9006901.
- ^Nantel A, Huber M, Thomas DY (December 1999)."Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool".J Biol Chem.274(50): 35719–24.doi:10.1074/jbc.274.50.35719.PMID10585452.
- ^abNantel A, Mohammad-Ali K, Sherk J, Posner BI, Thomas DY (April 1998)."Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases".J Biol Chem.273(17): 10475–84.doi:10.1074/jbc.273.17.10475.PMID9553107.
- ^Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002)."Role for the adaptor protein Grb10 in the activation of Akt".Mol Cell Biol.22(4): 979–91.doi:10.1128/MCB.22.4.979-991.2002.PMC134632.PMID11809791.
- ^Langlais P, Dong LQ, Hu D, Liu F (June 2000)."Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family".Oncogene.19(25): 2895–903.doi:10.1038/sj.onc.1203616.PMID10871840.
- ^Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H (April 1996)."Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus".J Biol Chem.271(15): 8882–6.doi:10.1074/jbc.271.15.8882.PMID8621530.
- ^Liu F, Roth RA (October 1995)."Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function".Proc Natl Acad Sci U S A.92(22): 10287–91.Bibcode:1995PNAS...9210287L.doi:10.1073/pnas.92.22.10287.PMC40781.PMID7479769.
- ^abHe W, Rose DW, Olefsky JM, Gustafson TA (March 1998)."Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains".J Biol Chem.273(12): 6860–7.doi:10.1074/jbc.273.12.6860.PMID9506989.
- ^Vecchione A, Marchese A, Henry P, Rotin D, Morrione A (May 2003)."The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor".Mol Cell Biol.23(9): 3363–72.doi:10.1128/MCB.23.9.3363-3372.2003.PMC153198.PMID12697834.
- ^Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW (June 1996)."Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10".Mol Endocrinol.10(6): 631–41.doi:10.1210/mend.10.6.8776723.PMID8776723.
- ^Morrione A, Valentinis B, Li S, Ooi JY, Margolis B, Baserga R (July 1996). "Grb10: A new substrate of the insulin-like growth factor I receptor".Cancer Res.56(14): 3165–7.PMID8764099.
- ^Pandey A, Duan H, Di Fiore PP, Dixit VM (September 1995)."The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10".J Biol Chem.270(37): 21461–3.doi:10.1074/jbc.270.37.21461.PMID7665556.
Further reading
[edit]- Ramírez-Dueñas ML, Medina C, Ocampo-Campos R, Rivera H (1992). "Severe Silver-Russell syndrome and translocation (17;20) (q25;q13)".Clin. Genet.41(1): 51–3.doi:10.1111/j.1399-0004.1992.tb03630.x.PMID1633648.S2CID28801507.
- Liu F, Roth RA (1995)."Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function".Proc. Natl. Acad. Sci. U.S.A.92(22): 10287–91.Bibcode:1995PNAS...9210287L.doi:10.1073/pnas.92.22.10287.PMC40781.PMID7479769.
- Pandey A, Duan H, Di Fiore PP, Dixit VM (1995)."The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10".J. Biol. Chem.270(37): 21461–3.doi:10.1074/jbc.270.37.21461.PMID7665556.
- Midro AT, Debek K, Sawicka A, et al. (1993). "Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25".Clin. Genet.44(1): 53–5.doi:10.1111/j.1399-0004.1993.tb03845.x.PMID8403458.S2CID20766311.
- Hansen H, Svensson U, Zhu J, et al. (1996)."Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus".J. Biol. Chem.271(15): 8882–6.doi:10.1074/jbc.271.15.8882.PMID8621530.
- Morrione A, Valentinis B, Li S, et al. (1996). "Grb10: A new substrate of the insulin-like growth factor I receptor".Cancer Res.56(14): 3165–7.PMID8764099.
- O'Neill TJ, Rose DW, Pillay TS, et al. (1996)."Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling".J. Biol. Chem.271(37): 22506–13.doi:10.1074/jbc.271.37.22506.PMID8798417.
- Stein E, Cerretti DP, Daniel TO (1996)."Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells".J. Biol. Chem.271(38): 23588–93.doi:10.1074/jbc.271.38.23588.PMID8798570.
- Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (1997)."Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains".J. Biol. Chem.272(5): 2659–67.doi:10.1074/jbc.272.5.2659.PMID9006901.
- Nagase T, Seki N, Ishikawa K, et al. (1997)."Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain".DNA Res.3(5): 321–9, 341–54.doi:10.1093/dnares/3.5.321.PMID9039502.
- He W, Rose DW, Olefsky JM, Gustafson TA (1998)."Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains".J. Biol. Chem.273(12): 6860–7.doi:10.1074/jbc.273.12.6860.PMID9506989.
- Nantel A, Mohammad-Ali K, Sherk J, et al. (1998)."Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases".J. Biol. Chem.273(17): 10475–84.doi:10.1074/jbc.273.17.10475.PMID9553107.
- Moutoussamy S, Renaudie F, Lago F, et al. (1998)."Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins".J. Biol. Chem.273(26): 15906–12.doi:10.1074/jbc.273.26.15906.PMID9632636.
- Bai RY, Jahn T, Schrem S, et al. (1998)."The SH2-containing adapter protein GRB10 interacts with BCR-ABL".Oncogene.17(8): 941–8.doi:10.1038/sj.onc.1202024.PMID9747873.
- Mano H, Ohya K, Miyazato A, et al. (1998)."Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase".Genes Cells.3(7): 431–41.doi:10.1046/j.1365-2443.1998.00201.x.PMID9753425.S2CID6391234.
- Washington University Genome Sequencing Cente (November 1998)."Toward a complete human genome sequence".Genome Res.8(11): 1097–108.doi:10.1101/gr.8.11.1097.PMID9847074.
- Angrist M, Bolk S, Bentley K, et al. (1999)."Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease".Oncogene.17(23): 3065–70.doi:10.1038/sj.onc.1202226.PMID9881709.
- Wang J, Dai H, Yousaf N, et al. (1999)."Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis".Mol. Cell. Biol.19(9): 6217–28.doi:10.1128/MCB.19.9.6217.PMC84567.PMID10454568.
External links
[edit]- GRB10+Proteinat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
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This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.