G cell
| G cell | |
|---|---|
 Control of stomach acid | |
| Details | |
| System | Digestive system |
| Location | Stomachandduodenum |
| Function | Gastrinsecretion |
| Identifiers | |
| Latin | endocrinocytus G |
| TH | H3.04.02.0.00031 |
| FMA | 67609 |
| Anatomical terms of microanatomy | |
AG cellorgastrin cellis a type of cell in the stomach and duodenum that secretesgastrin.It works in conjunction withgastric chief cellsandparietal cells.G cells are found deep within thepyloric glandsof thestomachantrum,and occasionally in thepancreas[1]andduodenum.Thevagus nerveinnervates the G cells.Gastrin-releasing peptideis released by the post-ganglionic fibers of the vagus nerve onto G cells duringparasympatheticstimulation. The peptide hormonebombesinalso stimulates gastrin from G cells. Gastrin-releasing peptide, as well as the presence ofamino acidsin the stomach, stimulates the release of gastrin from the G cells. Gastrin stimulatesenterochromaffin-like cellsto secretehistamine.[2]Gastrin also targetsparietal cellsby increasing the amount of histamine and the direct stimulation by gastrin, causing the parietal cells to increaseHClsecretion in the stomach. G-cells frequently expressPD-L1during homeostasis which protects them fromHelicobacter pylori-induced immune destruction[3]
Structure
[edit]
G cells have a distinctive microscopic appearance that allows one to separate them from other cells in the gastric antrum; their nuclei are centrally located in the cell. They are found in the middle portion of thegastric glands.
See also
[edit]References
[edit]- ^"G cell",Medcyclopaedia,GE[dead link]
- ^Guyton, Arthur C.; John E. Hall (2006).Textbook of Medical Physiology(11 ed.). Philadelphia: Elsevier Saunders. p. 797.ISBN0-7216-0240-1.
- ^Mommersteeg MC, Yu BT, van den Bosch TP, von der Thüsen JH, Kuipers EJ, Doukas M, Spaander MC, Peppelenbosch MP, Fuhler GM (October 2022)."Constitutive programmed death ligand 1 expression protects gastric G-cells from Helicobacter pylori-induced inflammation".Helicobacter.27(5): e12917.doi:10.1111/hel.12917.PMC9542424.PMID35899973.
External links
[edit]
Media related toG cellat Wikimedia Commons- Definition at thefreedictionary
