Jump to content

Genetic admixture

From Wikipedia, the free encyclopedia

Genetic admixtureoccurs when previouslyisolatedpopulations interbreed resulting in a population that is descended from multiple sources. It can occur between species, such as withhybrids,or within species, such as when geographically distant individuals migrate to new regions. It results ingene poolthat is a mix of the source populations.[1][2][3]

Examples

[edit]

Climatic cycles facilitate genetic admixture in cold periods and genetic diversification in warm periods.[4] Naturalfloodingcan cause genetic admixture within populations of migrating fish species.[5] Genetic admixture may have an important role for the success of populations that colonise a new area andinterbreedwith individuals of native populations.[6]

Mapping

[edit]

Admixture mapping is a method ofgene mappingthat uses apopulationof mixed ancestry (an admixed population) to find the geneticlocithat contribute to differences in diseases or otherphenotypesfound between the different ancestral populations. The method is best applied to populations with recent admixture from two populations that were previously genetically isolated. The method attempts to correlate the degree of ancestry near a genetic locus with the phenotype or disease of interest. Genetic markers that differ in frequency between the ancestral populations are needed across the genome.[7]

Admixture mapping is based on the assumption that differences in disease rates or phenotypes are due in part to differences in the frequencies of disease-causing or phenotype-causing genetic variants between populations. In an admixed population, these causal variants occur more frequently on chromosomal segments inherited from one or another ancestral population. The first admixture scans were published in 2005 and since then genetic contributors to a variety of disease and trait differences have been mapped.[8]By 2010, high-density mapping panels had been constructed for African Americans, Latino/Hispanics, andUyghurs.

See also

[edit]

References

[edit]
  1. ^Korunes, Katharine L.; Goldberg, Amy (2021-03-11)."Human genetic admixture".PLOS Genetics.17(3). Public Library of Science (PLoS): e1009374.doi:10.1371/journal.pgen.1009374.ISSN1553-7404.PMC7951803.
  2. ^Rius, M.; Darling, J.A. (2014). "How important is intraspecific genetic admixture to the success of colonising populations?".Trends in Ecology & Evolution.29(4): 233−242.doi:10.1016/j.tree.2014.02.003.PMID24636862.
  3. ^Yang, Melinda A.; Fu, Qiaomei (March 2018). "Insights into Modern Human Prehistory Using Ancient Genomes".Trends in Genetics.34(3): 184–196 6y.doi:10.1016/j.tig.2017.11.008.PMID29395378.
  4. ^Lv X, Cheng J, Meng Y, Chang Y, Xia L, Wen Z, Ge D, Liu S, Yang Q (2018)."Disjunct distribution and distinct intraspecific diversification ofEothenomys melanogasterin South China ".BMC Evolutionary Biology.18(1): 50.doi:10.1186/s12862-018-1168-3.PMC5894153.PMID29636000.
  5. ^Jaisuk, C.; Senanan, W. (2018)."Effects of landscape features on population genetic variation of a tropical stream fish, Stone lapping minnow,Garra cambodgiensis,in the upper Nan River drainage basin, northern Thailand ".PeerJ.6:e4487.doi:10.7717/peerj.4487.PMC5845392.PMID29568710.
  6. ^Kolbe JJ, Larson A, Losos JB, de Queiroz K (2008)."Admixture determines genetic diversity and population differentiation in the biological invasion of a lizard species".Biology Letters.4(4): 434−437.doi:10.1098/rsbl.2008.0205.PMC2610154.PMID18492644.
  7. ^Shriver, MD; et al. (April 2003). "Skin pigmentation, biogeographical ancestry and admixture mapping".Human Genetics.112(4): 387–99.doi:10.1007/s00439-002-0896-y.PMID12579416.S2CID7877572.
  8. ^Winkler, C. A.; Nelson, G. W.; Smith, M. W. (2010)."Admixture mapping comes of age".Annu Rev Genom Hum Genet.11:65–89.doi:10.1146/annurev-genom-082509-141523.PMC7454031.PMID20594047.

Further reading

[edit]
Retrieved from "https://en.wikipedia.org/w/index.php?title=Genetic_admixture&oldid=1225428701"