Glucosidases
 | This articleneeds additional citations forverification.(September 2021) |
Glucosidasesare theglycoside hydrolaseenzymescategorized under theEC number3.2.1.[1]
Function
[edit]Alpha-glucosidasesare enzymes involved in breaking down complex carbohydrates such asstarchandglycogeninto theirmonomers.[2]
They catalyze the cleavage of individualglucosylresidues from variousglycoconjugatesincluding Alpha - or beta-linked polymers of glucose. This enzyme convert complex sugars into simpler ones.
Members
[edit]Different sources include different members in this class. Members marked with a "#" are considered byMeSHto be glucosidases.
| Name | EC | Description |
|---|---|---|
| α-Amylase | EC3.2.1.1 | is adigestiveenzyme inmammals |
| β-Amylase | EC3.2.1.2 | is aplantenzyme to break downstarch |
| γ-Amylase | EC3.2.1.3 | is a digestive enzyme |
| Cellulase# | EC3.2.1.4 | breaks downcellulosefrom plant material |
| Sucrase-isomaltase | EC3.2.1.10 | - |
| Mannosyl-oligosaccharide glucosidase# | EC 3.2.1.106 | catalyzes the first trimming step of the N-glycosylation pathway; is associated withCongenital Disorder of Glycosylation type IIb |
| Acid α-glucosidase# | EC3.2.1.20 | is associated withGlycogen storage disease type II |
| Beta-glucosidase# | EC3.2.1.21 | is associated withGaucher's disease |
| Lactase | EC3.2.1.23 | one member of theβ-galactosidasefamily, breaks downmilksugars, and its absence inadulthoodcauseslactose intolerance |
| Debranching enzyme# | EC3.2.1.33 | in mammals, yeast and some bacteria, combines transferase and glucosidase activity in glycogen breakdown |
| Pullulanase | EC3.2.1.41 | has been used as adetergent |
Clinical significance
[edit]Alpha-glucosidases are targeted byAlpha -glucosidase inhibitorssuch asacarboseandmiglitolto controldiabetes mellitus type 2.
See also
[edit]References
[edit]- ^"ENZYME class: 3.2.1".enzyme.expasy.org.SIB Swiss Institute of Bioinformatics. June 2021.Retrieved2021-09-13.
- ^Krasikov, V. V.; Karelov, D. V.; Firsov, L. M. (March 2001)."α-Glucosidases".Biochemistry (Moscow).66(3): 267–281.doi:10.1023/A:1010243611814.PMID11333149.
External links
[edit]- Glucosidasesat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
