HMGN2

HMGN2
Identifiers
Aliases	HMGN2,HMG17, high mobility group nucleosomal binding domain 2
External IDs	OMIM:163910;HomoloGene:136792;GeneCards:HMGN2;OMA:HMGN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.11 Start 26,472,440bp End 26,476,642bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in ventricular zone ganglionic eminence right uterine tube pituitary gland anterior pituitary bone marrow cells left ovary thyroid gland endometrium right lobe of thyroid gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function nucleosomal DNA binding DNA binding protein binding RNA binding Cellular component chromatin extracellular space nucleus cytoplasm Biological process antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 3151 n/a Ensembl ENSG00000198830 n/a UniProt P05204 n/a RefSeq (mRNA) NM_005517 n/a RefSeq (protein) NP_005508 n/a Location (UCSC) Chr 1: 26.47 – 26.48 Mb n/a PubMedsearch n/a
Wikidata
View/Edit Human

Non-histone chromosomal protein HMG-17is aproteinthat in humans is encoded by theHMGN2gene.

See also

• High mobility group protein HMG14 and HMG17
• HMGN1(HMG-14)

Further reading

• Giancotti V, Bandiera A, Buratti E, et al. (1991). "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein".Eur. J. Biochem.198(1): 211–6.doi:10.1111/j.1432-1033.1991.tb16003.x.PMID2040281.
• Popescu N, Landsman D, Bustin M (1990). "Mapping the human gene coding for chromosomal protein HMG-17".Hum. Genet.85(3): 376–8.doi:10.1007/BF00206764.PMID2394451.S2CID11160792.
• Landsman D, McBride OW, Bustin M (1989)."Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family".Nucleic Acids Res.17(6): 2301–14.doi:10.1093/nar/17.6.2301.PMC317597.PMID2565024.
• Landsman D, Soares N, Gonzalez FJ, Bustin M (1986)."Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family".J. Biol. Chem.261(16): 7479–84.doi:10.1016/S0021-9258(17)38417-X.PMID3754870.
• Leffak M, Trempe JP (1985)."Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus".Nucleic Acids Res.13(13): 4853–69.doi:10.1093/nar/13.13.4853.PMC321831.PMID4022776.
• Postnikov YV, Trieschmann L, Rickers A, Bustin M (1995)."Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores".J. Mol. Biol.252(4): 423–32.doi:10.1006/jmbi.1995.0508.PMID7563062.
• Hock R, Scheer U, Bustin M (1999)."Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport".J. Cell Biol.143(6): 1427–36.doi:10.1083/jcb.143.6.1427.PMC2132996.PMID9852141.
• Herrera JE, Sakaguchi K, Bergel M, et al. (1999)."Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes".Mol. Cell. Biol.19(5): 3466–73.doi:10.1128/MCB.19.5.3466.PMC84139.PMID10207070.
• Kazmierczak B, Dal Cin P, Rogalla P, et al. (2000). "Regional fine mapping of HMG17 to chromosomal band 1p35".Cancer Genet. Cytogenet.116(2): 164–5.doi:10.1016/S0165-4608(99)00137-5.PMID10640150.
• Bergel M, Herrera JE, Thatcher BJ, et al. (2000)."Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes".J. Biol. Chem.275(15): 11514–20.doi:10.1074/jbc.275.15.11514.PMID10753971.
• Bustin M (2001). "Revised nomenclature for high mobility group (HMG) chromosomal proteins".Trends Biochem. Sci.26(3): 152–3.doi:10.1016/S0968-0004(00)01777-1.PMID11246012.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001)."Identification and characterization of the potential promoter regions of 1031 kinds of human genes".Genome Res.11(5): 677–84.doi:10.1101/gr.gr-1640r.PMC311086.PMID11337467.
• Birger Y, Ito Y, West KL, et al. (2001). "HMGN4, a newly discovered nucleosome-binding protein encoded by an intronless gene".DNA Cell Biol.20(5): 257–64.doi:10.1089/104454901750232454.PMID11410162.
• Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001)."Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin".Mol. Cell. Biol.21(15): 5169–78.doi:10.1128/MCB.21.15.5169-5178.2001.PMC87241.PMID11438671.
• Porkka K, Laakkonen P, Hoffman JA, et al. (2002)."A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo".Proc. Natl. Acad. Sci. U.S.A.99(11): 7444–9.Bibcode:2002PNAS...99.7444P.doi:10.1073/pnas.062189599.PMC124250.PMID12032302.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006)."The DNA sequence and biological annotation of human chromosome 1".Nature.441(7091): 315–21.Bibcode:2006Natur.441..315G.doi:10.1038/nature04727.PMID16710414.