HOXC11
Homeobox protein Hox-C11is aproteinthat in humans is encoded by theHOXC11gene.[5][6][7]
This gene belongs to thehomeoboxfamily of genes. The homeobox genes encode a highly conserved family oftranscription factorsthat play an important role inmorphogenesisin all multicellular organisms.
Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on differentchromosomesand consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster onchromosome 12.The product of this gene binds to a promoter element of thelactase-phlorizin hydrolase.It also may play a role in earlyintestinaldevelopment. An alternatively spliced variant encoding a shorterisoformhas been described but its full-length nature has not been determined.[7]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000123388–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000001656–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes".Genomics.7(3): 460.doi:10.1016/0888-7543(90)90186-X.PMID1973146.
- ^Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature".Cell.71(4): 551–553.doi:10.1016/0092-8674(92)90588-4.PMID1358459.S2CID13370372.
- ^ab"Entrez Gene: HOXC11 homeobox C11".
Further reading
[edit]- Acampora D, D'Esposito M, Faiella A, et al. (1990)."The human HOX gene family".Nucleic Acids Res.17(24): 10385–10402.doi:10.1093/nar/17.24.10385.PMC335308.PMID2574852.
- Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987)."Cognate homeo-box loci mapped on homologous human and mouse chromosomes".Proc. Natl. Acad. Sci. U.S.A.83(23): 9104–9108.Bibcode:1986PNAS...83.9104R.doi:10.1073/pnas.83.23.9104.PMC387083.PMID2878432.
- Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters".Cytogenet. Cell Genet.73(1–2): 114–115.doi:10.1159/000134320.PMID8646877.
- Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines".FEBS Lett.415(3): 263–267.Bibcode:1997FEBSL.415..263F.doi:10.1016/S0014-5793(97)01118-6.PMID9357979.S2CID26075369.
- Mitchelmore C, Troelsen JT, Sjöström H, Norén O (1998)."The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1 Alpha -dependent transcription".J. Biol. Chem.273(21): 13297–13306.doi:10.1074/jbc.273.21.13297.PMID9582375.
- Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes".Teratology.65(2): 50–62.doi:10.1002/tera.10009.PMID11857506.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–16903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–2127.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Zhang X, Hamada J, Nishimoto A, et al. (2007)."HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells".J. Cell. Mol. Med.11(2): 299–306.doi:10.1111/j.1582-4934.2007.00020.x.PMC3822828.PMID17488478.
External links
[edit]- HOXC11+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.